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2.4.1.38: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase

This is an abbreviated version!
For detailed information about beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, go to the full flat file.

Word Map on EC 2.4.1.38

Reaction

UDP-alpha-D-galactose
+
N-acetyl-beta-D-glucosaminylglycopeptide
=
UDP
+
beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide

Synonyms

(alpha4Gal-T1), 4betaGalT, acetyllactosamine synthetase, alpha-1,4-galactosyltransferase I, B4GALT1, beta 1, 4-GalT-I, beta 1,4-galactosyltransferase 1, beta 1,4-GalT-I, beta 1,4GalT V, beta(1,4)-galactosyltransferase, beta(1,4)-GalT, beta(1,4)-GT, beta-1,4 galactosyltransferase I, beta-1,4 galactosyltransferase V, beta-1,4-galactosyltransferase, beta-1,4-galactosyltransferase 1, beta-1,4-galactosyltransferase I, beta-1,4-galactosyltransferase IV, beta-1,4-galactosyltransferase-I, beta-1,4-GalT, beta-1,4-GalT I, beta-1,4-GalT V, beta-1,4-GalT-I, beta-1,4-GalT5, beta-1,4-GalT6, beta-1,4-GalT7, beta-1,4-GT-IV, beta-N-acetyl-beta1-4-galactosyltransferase, beta-N-acetylglucosaminide beta1-4-galactosyltransferase, beta1,4-Gal-transferase T1, beta1,4-galactosyltransferase, beta1,4-galactosyltransferase 1, beta1,4-galactosyltransferase 7, beta1,4-galactosyltransferase I, beta1,4-galactosyltransferase II, beta1,4-galactosyltransferase V, beta1,4-galactosyltransferase-1, beta1,4-galactosyltransferase-I, beta1,4-galactosyltransferase1, beta1,4-GalT1, beta1,4-GalT7, beta1,4-GT, beta1,4-GT 1, beta1,4GalT II, beta1,4GT1, beta1-4-galactosyltransferase, beta1-4GalT, beta1-4GalT1, beta4 Gal-transferase, beta4-GalT-I, beta4-GalT-II, beta4-GalT-III, beta4-GalT-IV, beta4-GalT-V, beta4Gal-T1, beta4GalT, beta4GalT-II, beta4GalT1, beta4GalT7, betaGalT, betaGalT-1, betaGALT1, betaGT, EC 2.4.1.98, Gal-T, Gal-T1, galactosyltransferase 7, galactosyltransferase, uridine diphosphogalactose-acetylglucosamine, GalNAcT2, GALT, GalT I, GalT V, GalT1, GalTase, GalTI, glycoprotein 4-beta-galactosyl-transferase, glycoprotein beta-galactosyltransferase, HP0826, lactosamine synthase, lactosamine synthetase, lactose synthetase A protein, LgtB, LgtB-A, LgtB-B, LgtH, More, N-acetylglucosamine beta1,4 galactosyltransferase, N-acetyllactosamine synthetase, NAL synthetase, thyroid galactosyltransferase, thyroid glycoprotein beta-galactosyltransferase, UDP-beta-1,4-galactosyltransferase, UDP-Gal:betaGlcNAc beta-1,4-galactosyltransferase, polypeptide 1, UDP-Gal:N-acetylglucosamine beta1-4-galactosyltransferase, UDP-galactose N-acetylglucosamine beta-4-galactosyltransferase, UDP-galactose-acetylglucosamine galactosyltransferase, UDP-galactose-N-acetylglucosamine beta-1,4-galactosyltransferase, UDP-galactose-N-acetylglucosamine galactosyltransferase, UDP-galactose:N-acetylglucosaminide beta1-4-galactosyltransferase, UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferase 2, UDPgalactose-glycoprotein galactosyltransferase, UDPgalactose-N-acetylglucosamine beta-D-galactosyltransferase, UDPgalactose:N-acetyl-beta-D-glucosaminylglycopeptide beta-1,4-galactosyltransferase, UDPgalactose:N-acetylglucosaminyl(beta1-4)galactosyltransferase, uridine diphosphogalactose-acetylglucosamine galactosyltransferase, uridine diphosphogalactose-glycoprotein galactosyltransferase

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.1 Hexosyltransferases
                2.4.1.38 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase

Expression

Expression on EC 2.4.1.38 - beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
anti-TNFR1 antibody suppresses the expression of beta-1,4-GalT I, and TNF-alpha autocrine
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beta 1, 4-GalT-I iss highly expressed in endometrium during implantation window
-
beta-1,4-GalT-I mRNA is significant increased 2 h after lipopolysaccharide stimulation with 0.001 mg/ml
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CDK11p58 and beta-1,4-GalT-I are induced in lipopolysaccharide-challenged rat primary astrocytes in a affinis dose- and time-dependent manner. CDK11p58 regulates the expression of beta-1,4-GalT-I by interacting with it. The expression of beta-1,4-GalT-I increases, and astrocyte activation enhances due to the overexpression of CDK11p58
-
estrogen antagonists ICI 182,780 and ER-a-ERE binding blocker TPBM inhibit the expression of estrogen-induced B4GALT1
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estrogen induces beta-1,4-galactosyltransferase 1 expression
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expression of beta1,4-GalT-I and galactose-containing glycans increases in synovial tissue of rheumatoid arthritis patients compared with osteoarthritis patients and healthy controls. Most galactose-containing glycans and beta1,4-GalT-I are expressed in inflammatory cells
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expression of beta1,4-GalT-I increases in the cartilage and synovial tissue of osteoarthritis patients compared with healthy controls
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inhibition of MEK/ERK, PI3K/AKT and NF-kappaB suppresses recombinant human osteopontin-induced beta1,4-GalT-I expression
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mRNA and protein expression of beta1,4-GalT-I increases in synovial tissue of a collagen-induced rat model of rheumatoid arthritis compared with the normal group at 10d and 15d after collagen-induced
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recombinant human osteopontin protein induces the beta 1,4-GalT-I up-regulation in RL95-2 cells
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the expression level of GalTI and cellular adhesion ability is increased when dendritic cells continue to mature
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the transcriptional activity and mRNA expression level of beta1,4GalT II are dramatically induced by p53 transcription factor in HeLa cell, in response to DNA damage agent adriamycin, the mRNA expression and promoter activity of beta1,4GalT II are significantly up-regulated
-