This is an abbreviated version! For detailed information about beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, go to the full flat file.
decreasing the expression of beta1,4GalT V by RNA interference in glioma cells attenuates the formation of polylactosamine and inhibits the ability of tumor formation in vivo. Down-regulation of beta1,4GalT V depletes CD133-positive cells in glioma xenograft, and inhibits the self-renewal capacity and the tumorigenic potential of glioma-initiating cells
knockdown of beta-1,4-GalT-I reduces the activation potentiation caused by the overexpression of CDK11p58, illustrating the function of CDK11p58 to promote astrocyte activation depends on beta-1,4-GalT-I
Lac-Cer synthase activity is significantly decreased in mouse embryonic fibroblast (MEF) derived from beta-1,4-GalT V (B4galt5)-mutant mice, indicating that that murine beta-1,4-GalT V is involved in Lac-Cer biosynthesis
lobe B depletion of the conserved oligomeric Golgi complex severely alters the stability of beta1,4-galactosyltransferase1 (B4GALT1) and alpha2,6-sialyltransferase 1 (ST6GAL1)
overexpression of beta-1,4-GalT-I represses Schwann cell proliferation induced by low concentration of TNF-alpha via ERK1/2 signal pathway and TNFR2, while knocking down beta-1,4-GalT I expression inhibits Schwann cell apoptosis induced by high concentration of TNF-alpha via P38, JNK signal pathways, and TNFR1
silencing of beta-1,4-GalT I suppresses TNF-alpha autocrine, while overexpression of beta-1,4-GalT I promotes TNF-alpha autocrine in TNF-alpha-treated Schwann cells
the knock-down of the B4GALT1 gene and the inhibition of membrane B4GALT1 function results in the significant inhibition of estrogen-induced proliferation of MCF-7 cells
beta4Gal-T1 interacts with alpha-lactalbumin to form the lactose synthase complex that transfers galactose from UDP-alpha-D-Gal to glucose, producing the lactose secreted in milk
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1 and UDP-Gal:betaGlcNAc beta-1,4-galactosyltransferase polypeptide1 physically associate in vitro and in cultured cells recruiting one another to the endoplasmic reticulum
beta-1,4-GalT I plays a positive role in the regulation of TNF-alpha-induced TNF-alpha secretion. It promotes the activation of ERK, JNK, and P38 MAP kinase signal pathways which subsequently enhance TNF-alpha secretion in TNF-alpha-treated Schwann cells
beta-1,4-GalT I plays an important role in Schwann cell proliferation and apoptosis induced by TNF-alpha via different signal pathways and TNF-alpha receptor
in Neuro2a cells it is shown that beta4GalT-II associates with glucuronyltransferase. beta4GalT-II enhances kinetic efficacy of glucuronyltransferase. Co-expression of beta4GalT-II and glucuronyltransferase increase HNK-1 expression on various glycoproteins in N2a cells, including neural cell adhesion molecule
the specific enzyme complex of beta4GalT-II with glucuronyltransferase plays an important role in the biosynthesis of human natural killer-1 carbohydrate
direct interaction between the enzyme and epidermal growth factor receptor inhibits epidermal growth factor receptor activation in hepatocellular carcinoma