2.4.1.38: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase This is an abbreviated version! For detailed information about beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, go to the full flat file .
Reaction
UDP-alpha-D-galactose +
N-acetyl-beta-D-glucosaminylglycopeptide =
UDP +
beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide
Synonyms (alpha4Gal-T1), 4betaGalT, acetyllactosamine synthetase, alpha-1,4-galactosyltransferase I, B4GALT1, beta 1, 4-GalT-I, beta 1,4-galactosyltransferase 1, beta 1,4-GalT-I, beta 1,4GalT V, beta(1,4)-galactosyltransferase, beta(1,4)-GalT, beta(1,4)-GT, beta-1,4 galactosyltransferase I, beta-1,4 galactosyltransferase V, beta-1,4-galactosyltransferase, beta-1,4-galactosyltransferase 1, beta-1,4-galactosyltransferase I, beta-1,4-galactosyltransferase IV, beta-1,4-galactosyltransferase-I, beta-1,4-GalT, beta-1,4-GalT I, beta-1,4-GalT V, beta-1,4-GalT-I, beta-1,4-GalT5, beta-1,4-GalT6, beta-1,4-GalT7, beta-1,4-GT-IV, beta-N-acetyl-beta1-4-galactosyltransferase, beta-N-acetylglucosaminide beta1-4-galactosyltransferase, beta1,4-Gal-transferase T1, beta1,4-galactosyltransferase, beta1,4-galactosyltransferase 1, beta1,4-galactosyltransferase 7, beta1,4-galactosyltransferase I, beta1,4-galactosyltransferase II, beta1,4-galactosyltransferase V, beta1,4-galactosyltransferase-1, beta1,4-galactosyltransferase-I, beta1,4-galactosyltransferase1, beta1,4-GalT1, beta1,4-GalT7, beta1,4-GT, beta1,4-GT 1, beta1,4GalT II, beta1,4GT1, beta1-4-galactosyltransferase, beta1-4GalT, beta1-4GalT1, beta4 Gal-transferase, beta4-GalT-I, beta4-GalT-II, beta4-GalT-III, beta4-GalT-IV, beta4-GalT-V, beta4Gal-T1, beta4GalT, beta4GalT-II, beta4GalT1, beta4GalT7, betaGalT, betaGalT-1, betaGALT1, betaGT, EC 2.4.1.98, Gal-T, Gal-T1, galactosyltransferase 7, galactosyltransferase, uridine diphosphogalactose-acetylglucosamine, GalNAcT2, GALT, GalT I, GalT V, GalT1, GalTase, GalTI, glycoprotein 4-beta-galactosyl-transferase, glycoprotein beta-galactosyltransferase, HP0826, lactosamine synthase, lactosamine synthetase, lactose synthetase A protein, LgtB, LgtB-A, LgtB-B, LgtH, More, N-acetylglucosamine beta1,4 galactosyltransferase, N-acetyllactosamine synthetase, NAL synthetase, thyroid galactosyltransferase, thyroid glycoprotein beta-galactosyltransferase, UDP-beta-1,4-galactosyltransferase, UDP-Gal:betaGlcNAc beta-1,4-galactosyltransferase, polypeptide 1, UDP-Gal:N-acetylglucosamine beta1-4-galactosyltransferase, UDP-galactose N-acetylglucosamine beta-4-galactosyltransferase, UDP-galactose-acetylglucosamine galactosyltransferase, UDP-galactose-N-acetylglucosamine beta-1,4-galactosyltransferase, UDP-galactose-N-acetylglucosamine galactosyltransferase, UDP-galactose:N-acetylglucosaminide beta1-4-galactosyltransferase, UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferase 2, UDPgalactose-glycoprotein galactosyltransferase, UDPgalactose-N-acetylglucosamine beta-D-galactosyltransferase, UDPgalactose:N-acetyl-beta-D-glucosaminylglycopeptide beta-1,4-galactosyltransferase, UDPgalactose:N-acetylglucosaminyl(beta1-4)galactosyltransferase, uridine diphosphogalactose-acetylglucosamine galactosyltransferase, uridine diphosphogalactose-glycoprotein galactosyltransferase
ECTree
Inhibitors
Inhibitors on EC 2.4.1.38 - beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
1,6-dithio-N-butyryl-GlcNbeta-(2-naphthyl)
-
45% inhibition at 1.0 mM
1-thio-N-butyryl-GlcNbeta-(2-naphthyl)
-
uncompetitive, complete inhibition at 1.0 mM, 85% inhibition at 0.2 mM
1-thioGlcNAcbeta-(2-naphthyl)
-
91% inhibition at 1.0 mM
2-naphthylmethyl 2-acetamido-3,6-di-O-acetyl-2,4-dideoxy-4-fluoro-beta-D-glucopyranosyl-(1,3)-2,4,6-tri-O-acetyl-beta-D-galactopyranoside
-
2-naphthylmethyl 2-acetamido-3,6-di-O-acetyl-2,4-dideoxy-4-methoxy-beta-D-glucopyranosyl-(1,3)-2,4,6-tri-O-acetyl-beta-D-galactopyranoside
-
2-naphthylmethyl 2-acetamido-3,6-di-O-acetyl-2,4-dideoxy-beta-D-glucopyranosyl-(1,3)-2,4,6-tri-O-acetyl-beta-D-galactopyranoside
-
2-naphthylmethyl 2-acetamido-3,6-di-O-acetyl-4-amino-2,4-dideoxy-beta-D-glucopyranosyl-(1,3)-2,4,6-tri-O-acetyl-beta-Dgalactopyranoside
-
2-naphthylmethyl 2-acetamido-3,6-di-O-acetyl-4-azido-2,4-dideoxy-beta-D-glucopyranosyl-(1,3)-2,4,6-tri-O-acetyl-beta-Dgalactopyranoside
-
2-naphthylmethyl 2-acetamido-4,6-di-O-acetyl-2,3-dideoxy-3-fluoro-beta-D-glucopyranosyl-(1,3)-2,4,6-tri-O-acetyl-beta-D-galactopyranoside
-
2-naphthylmethyl 2-acetamido-4,6-di-O-acetyl-2,3-dideoxy-3-methoxy-beta-D-glucopyranosyl-(1,3)-2,4,6-tri-O-acetyl-beta-D-galactopyranoside
-
2-naphthylmethyl 2-acetamido-4,6-di-O-acetyl-2,3-dideoxy-beta-D-glucopyranosyl-(1,3)-2,4,6-tri-O-acetyl-beta-Dgalactopyranoside
-
4-methylumbelliferyl 4-deoxy-4-fluoro-beta-D-xylopyranoside
-
4-methylumbelliferyl 4-deoxy-beta-D-xylopyranoside
-
5'-alpha-D-galactopryanosyl-diphospho-5-(1H-indol-4-yl)-uridine
-
-
5'-alpha-D-galactopryanosyl-diphospho-5-[5-({[1-(1H-indol-3-yl)ethyl]amino}methyl)thiophene-2-yl]uridine
-
-
5-(5-formylthien-2-yl)-UDP-alpha-D-galactose
-
-
5-(5-formylthien-2-yl)-uridine
-
-
5-(indol-4-yl)-uridine
-
-
5-[5-({[1-(1H-indol-3-yl)ethyl]amino}methyl)thiophene-2-yl]uridine
-
-
6-thio-N-butyryl-GlcNbeta-(2-naphthyl)
-
19% inhibition at 1.0 mM
alpha1-Acid glycoprotein
-
above 1.4 mM with respect to acceptor sites
-
ammonium
enzyme activity is decreased in ammonium treated cell culture
Glc-NAcbeta1-3Galbeta-O-naphthalenemethanol
-
GlcNAcbeta-(2-naphthyl)
-
92% inhibition at 1.0 mM
N-Acetylimidazole
-
activity is partially restored by treatment with hydroxylamine
N-butyryl-GlcNbeta-(2-naphthyl)
-
87% inhibition at 1.0 mM
p-hydroxymercuribenzoate
-
-
p-nitrophenyl 2-acetamido-2-deoxy-beta-glucoside
-
competitively inhibits the transfer of galactose to glycoprotein substrates
phosphatidylethanolamine
-
-
UMP
-
competitively inhibits the transfer of galactose to glycoprotein substrates
uridine 5'-(6-amino-(2-[(7-bromomethyl-2-naphthyl)methoxycarbonylmethoxy]ethoxy)acetyl-6-deoxy-alpha-D-galactopyranosyl) diphosphate
-
irreversible, modifies residue Trp310
uridine 5'-(6-amino-(2-[(7-methyl-2-naphthyl)methoxycarbonylmethoxy]ethoxy)acetyl-6-deoxy-alpha-D-galactopyranosyl) diphosphate
-
-
uridine 5'-(6-O-[10-(2-naphthyl)-3,6,9-trioxadecanyl]-alpha-D-galactopyranosyl)diphosphate
-
competitive versus UDP-Gal, blocks acceptor substrate binding by the enzyme in presence of Mn2+
alpha-lactalbumin
-
inhibits reaction with UDPgalactose and N-acetylglucosamine
-
alpha-lactalbumin
-
inhibits the reaction of EC 2.4.1.38 with the complex glucoside colchicoside
-
alpha-lactalbumin
-
inhibits reaction with UDPgalactose and N-acetylglucosamine
-
alpha-lactalbumin
-
cellular adhesion ability of dendritic cells is inhibited by alpha-lactalbumin via interference with cell surface GalTI
-
alpha-lactalbumin
-
partially inhibits reaction with UDPgalactose and asialo-agalacto-transferrin
-
alpha-lactalbumin
-
inhibits N-acetyllactosamine synthesis in plasma membrane fraction
-
alpha-lactalbumin
-
inhibits reaction with UDPgalactose and N-acetylglucosamine
-
Cu2+
-
complete inhibition in presence of Mn2+
Cu2+
-
complete inhibition in presence of Mn2+
EDTA
-
-
N-acetylglucosamine
-
above 10 mM
N-acetylglucosamine
-
competitively inhibits the transfer of galactose to glycoprotein substrates
phosphatidic acid
-
-
UDP
-
treatment with periodate-cleaved UDP and NaCNBH3 results in a loss of 80% of enzyme activity, which is largely prevented by UDP-galactose
UDP
-
competitively inhibits the transfer of galactose to glycoprotein substrates
Zn2+
-
complete inhibition in presence of Mn2+
Zn2+
-
complete inhibition in presence of Mn2+
additional information
-
the enzyme is totally inactivated by iodination with lactoperoxidase, EC 1.11.1.7. Substrates protect against inactivation
-
additional information
-
inhibitor synthesis and potency, mechanism of inhibition, overview
-
additional information
in vivo galactosylation and sialylation inhibition is mainly due to decreased gene expression of galactosyltransferase, sialyltransferase, and CMP-sialic acid transporter and not due to sialidase
-
additional information
-
development and synthesis of mechanism-based inhibitors, structure analysis, overview
-
additional information
-
As2O3 significantly decreases beta 1,4GalT V expression level in in glioma cells, which increases the glioma cell apoptosis induced by As2O3, overviewoverview
-
additional information
-
structural features for rational design of specific inhibitors, overview
-
additional information
-
the constitutively active Akt protein, myr-Akt, inhibits CHX-induced apoptosis in SMMC-7721 cells through downregulating beta1,4GT1
-
additional information
-
not inhibited by CDP, UDP-mannose, and UDP-N-acetyl-beta-D-glucosamine
-
additional information
-
bis(oxalate)oxovanadium(IV), bis(maltolato)oxovanadium(IV), bis(kojato)oxovanadium(IV) and bis(2,2'-bipyridine)oxovanadium(IV) act as anti-diabetic drugs affecting the Golgi complex morphology and the enzyme activity, overview
-
additional information
-
TNF-alpha and its receptors affect the expression of beta-1,4 galactosyltransferase I mRNA by rat primary astrocytes, downregulation of beta-1,4-GalT I mRNA expression by TNF-alpha stimulation, overview; TNF-alpha and its receptors affect the expression of beta-1,4 galactosyltransferase V mRNA by rat primary astrocytes, overview
-
additional information
TNF-alpha and its receptors affect the expression of beta-1,4 galactosyltransferase I mRNA by rat primary astrocytes, downregulation of beta-1,4-GalT I mRNA expression by TNF-alpha stimulation, overview; TNF-alpha and its receptors affect the expression of beta-1,4 galactosyltransferase V mRNA by rat primary astrocytes, overview
-