2.4.1.38: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase This is an abbreviated version!go to the full flat file .
Reaction
UDP-alpha-D-galactose N-acetyl-beta-D-glucosaminylglycopeptide UDP beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide
Synonyms (alpha4Gal-T1), 4betaGalT, acetyllactosamine synthetase, alpha-1,4-galactosyltransferase I, B4GALT1, beta 1, 4-GalT-I, beta 1,4-galactosyltransferase 1, beta 1,4-GalT-I, beta 1,4GalT V, beta(1,4)-galactosyltransferase, beta(1,4)-GalT, beta(1,4)-GT, beta-1,4 galactosyltransferase I, beta-1,4 galactosyltransferase V, beta-1,4-galactosyltransferase, beta-1,4-galactosyltransferase 1, beta-1,4-galactosyltransferase I, beta-1,4-galactosyltransferase IV, beta-1,4-galactosyltransferase-I, beta-1,4-GalT, beta-1,4-GalT I, beta-1,4-GalT V, beta-1,4-GalT-I, beta-1,4-GalT5, beta-1,4-GalT6, beta-1,4-GalT7, beta-1,4-GT-IV, beta-N-acetyl-beta1-4-galactosyltransferase, beta-N-acetylglucosaminide beta1-4-galactosyltransferase, beta1,4-Gal-transferase T1, beta1,4-galactosyltransferase, beta1,4-galactosyltransferase 1, beta1,4-galactosyltransferase 7, beta1,4-galactosyltransferase I, beta1,4-galactosyltransferase II, beta1,4-galactosyltransferase V, beta1,4-galactosyltransferase-1, beta1,4-galactosyltransferase-I, beta1,4-galactosyltransferase1, beta1,4-GalT1, beta1,4-GalT7, beta1,4-GT, beta1,4-GT 1, beta1,4GalT II, beta1,4GT1, beta1-4-galactosyltransferase, beta1-4GalT, beta1-4GalT1, beta4 Gal-transferase, beta4-GalT-I, beta4-GalT-II, beta4-GalT-III, beta4-GalT-IV, beta4-GalT-V, beta4Gal-T1, beta4GalT, beta4GalT-II, beta4GalT1, beta4GalT7, betaGalT, betaGalT-1, betaGALT1, betaGT, EC 2.4.1.98, Gal-T, Gal-T1, galactosyltransferase 7, galactosyltransferase, uridine diphosphogalactose-acetylglucosamine, GalNAcT2, GALT, GalT I, GalT V, GalT1, GalTase, GalTI, glycoprotein 4-beta-galactosyl-transferase, glycoprotein beta-galactosyltransferase, HP0826, lactosamine synthase, lactosamine synthetase, lactose synthetase A protein, LgtB, LgtB-A, LgtB-B, LgtH, More, N-acetylglucosamine beta1,4 galactosyltransferase, N-acetyllactosamine synthetase, NAL synthetase, thyroid galactosyltransferase, thyroid glycoprotein beta-galactosyltransferase, UDP-beta-1,4-galactosyltransferase, UDP-Gal:betaGlcNAc beta-1,4-galactosyltransferase, polypeptide 1, UDP-Gal:N-acetylglucosamine beta1-4-galactosyltransferase, UDP-galactose N-acetylglucosamine beta-4-galactosyltransferase, UDP-galactose-acetylglucosamine galactosyltransferase, UDP-galactose-N-acetylglucosamine beta-1,4-galactosyltransferase, UDP-galactose-N-acetylglucosamine galactosyltransferase, UDP-galactose:N-acetylglucosaminide beta1-4-galactosyltransferase, UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferase 2, UDPgalactose-glycoprotein galactosyltransferase, UDPgalactose-N-acetylglucosamine beta-D-galactosyltransferase, UDPgalactose:N-acetyl-beta-D-glucosaminylglycopeptide beta-1,4-galactosyltransferase, UDPgalactose:N-acetylglucosaminyl(beta1-4)galactosyltransferase, uridine diphosphogalactose-acetylglucosamine galactosyltransferase, uridine diphosphogalactose-glycoprotein galactosyltransferase
ECTree
Natural Substrates Products
Natural Substrates Products on EC 2.4.1.38 - beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase
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UDP-alpha-D-galactose + N-acetyl-beta-D-glucosaminylglycopeptide
UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide
UDP-galactose + laminin
UDP + beta-1,4-D-galactosyl-laminin
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UDP-galactose + N-acetyl-beta-D-glucosaminylglycopeptide
UDP + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminylglycopeptide
UDPgalactose + N-acetylglucosaminyl at the non-reducing ends of protein-bound oligosaccharides
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additional information
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UDP-alpha-D-galactose + N-acetyl-beta-D-glucosaminylglycopeptide
UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide
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UDP-alpha-D-galactose + N-acetyl-beta-D-glucosaminylglycopeptide
UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide
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UDP-alpha-D-galactose + N-acetyl-beta-D-glucosaminylglycopeptide
UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide
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UDP-alpha-D-galactose + N-acetyl-beta-D-glucosaminylglycopeptide
UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide
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UDP-alpha-D-galactose + N-acetyl-beta-D-glucosaminylglycopeptide
UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide
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UDP-alpha-D-galactose + N-acetyl-beta-D-glucosaminylglycopeptide
UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide
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UDP-alpha-D-galactose + N-acetyl-beta-D-glucosaminylglycopeptide
UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide
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UDP-alpha-D-galactose + N-acetyl-beta-D-glucosaminylglycopeptide
UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide
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UDP-alpha-D-galactose + N-acetyl-beta-D-glucosaminylglycopeptide
UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide
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UDP-alpha-D-galactose + N-acetyl-beta-D-glucosaminylglycopeptide
UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide
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UDP-alpha-D-galactose + N-acetyl-beta-D-glucosaminylglycopeptide
UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide
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UDP-alpha-D-galactose + N-acetyl-beta-D-glucosaminylglycopeptide
UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide
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UDP-alpha-D-galactose + N-acetyl-beta-D-glucosaminylglycopeptide
UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide
Neisseria meningitidis serogroup A Z2491
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UDP-alpha-D-galactose + N-acetyl-beta-D-glucosaminylglycopeptide
UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide
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UDP-alpha-D-galactose + N-acetyl-beta-D-glucosaminylglycopeptide
UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide
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UDP-galactose + N-acetyl-beta-D-glucosaminylglycopeptide
UDP + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminylglycopeptide
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UDP-galactose + N-acetyl-beta-D-glucosaminylglycopeptide
UDP + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminylglycopeptide
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UDP-galactose + N-acetyl-beta-D-glucosaminylglycopeptide
UDP + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminylglycopeptide
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UDP-galactose + N-acetyl-beta-D-glucosaminylglycopeptide
UDP + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminylglycopeptide
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the enzyme effectively galactosylates the GlcNAcbeta1,6Man arm of the highly branched N-glycans that are characteristic of glioma, overview
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UDP-galactose + N-acetyl-beta-D-glucosaminylglycopeptide
UDP + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminylglycopeptide
the enzyme transfers galactose from UDP-galactose to N-acetylglucosamine residues of the branched N-linked oligosaccharide chains of glycoproteins
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UDPgalactose + N-acetylglucosaminyl at the non-reducing ends of protein-bound oligosaccharides
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UDPgalactose + N-acetylglucosaminyl at the non-reducing ends of protein-bound oligosaccharides
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the enzyme facilitates sperm binding to the oocyte zona pellucida
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UDPgalactose + N-acetylglucosaminyl at the non-reducing ends of protein-bound oligosaccharides
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enzyme participates in the biosynthesis of the oligosaccharide structures of glycoproteins and glycolipids
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UDPgalactose + N-acetylglucosaminyl at the non-reducing ends of protein-bound oligosaccharides
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enzyme functions in the coordinate biosynthesis of complex oligosaccharides, proposed to function in intercellular recognition and/or adhesion
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UDPgalactose + N-acetylglucosaminyl at the non-reducing ends of protein-bound oligosaccharides
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biosynthesis of keratan sulfate-like polysaccharides
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UDPgalactose + N-acetylglucosaminyl at the non-reducing ends of protein-bound oligosaccharides
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the enzyme may be involved in the synthesis of poly-N-acetyllactosamine, lacto-N-neotetraose and probably lacto-N-neotetraosylceramide in addition to the formation of the Galbeta1-4GlcNAc group of glycoprotein sugar chains and lactose
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UDPgalactose + N-acetylglucosaminyl at the non-reducing ends of protein-bound oligosaccharides
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main enzyme responsible for the transfer of galactose residues from UDPgalactose into terminal N-acetylglucosamine residues of complex-type oligosaccharides in newly synthesized glycoproteins in the Golgi apparatus. Deficiency of UDP-galactose:N-acetylglucosamine beta-1,4-galactosyltransferase I causes the congenital disorder of glycosylation type IId, a severe neurologic disease characterized by a hydrocephalus, myopathy and blood-clotting defects
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UDPgalactose + N-acetylglucosaminyl at the non-reducing ends of protein-bound oligosaccharides
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the enzyme is involved in the biosynthesis of a variety of carbohydrate structures in glycoproteins and glycolipids
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UDPgalactose + N-acetylglucosaminyl at the non-reducing ends of protein-bound oligosaccharides
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biosynthesis of carbohydrate moieties of glycoproteins and glycolipids, role in intercellular recognition and adhesion
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UDPgalactose + N-acetylglucosaminyl at the non-reducing ends of protein-bound oligosaccharides
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UDPgalactose + N-acetylglucosaminyl at the non-reducing ends of protein-bound oligosaccharides
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the soluble enzyme form from the luminal fluid of the epididymis is suggested to play a role on sperm maturation
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UDPgalactose + N-acetylglucosaminyl at the non-reducing ends of protein-bound oligosaccharides
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the enzyme may be involved in the synthesis of plasma glycoproteins by the liver during secretion, and may possibly be required for secretion of these proteins
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additional information
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the enzyme is part of the endoplasmic reticulum and Golgi glycosylation network, glycosyltransferase metabolism, overview
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additional information
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HP0826 is the beta-1,4-galactosyltransferase involved in the biosynthesis of the lipopolysaccharide O-chain backbone of Helicobacter pylori
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enzyme activity might be involved in apoptotic pathway in hepatocarcinoma cells
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decreasing the expression of GalT V in glioma cells promotes apoptosis, inhibits the invasion and migration and the ability of tumor formation in vivo, and reduces the activation of AKT, the enzyme functions as a glioma growth activator, overview, contribution of GalT V in the activation of AKT and MAPK kinase, contribution of serum or EGF in the transcription regulation of the GalT V gene, overview
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downregulation of the enzyme inhibits CDK11(p58)-mediated apoptosis induced by cycloheximide, while ectopically expressed beta1,4-GT 1 increases CDK11p58-mediated apoptosis
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the cell surface enzyme promotes apoptosis by inhibiting the epidermal growth factor receptor pathway via inhibition of the autophosphorylation of epidermal growth factor receptor especially at Try 1068, mechanism, overview
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tumor beta-1,4-galactosyltransferase IV overexpression is closely associated with colorectal cancer metastasis and poor prognosis, relationships between tumor beta-1,4-GT-IV overexpression and clinicopathologic characteristics, overview
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beta 1,4GalT V galactosylates the beta1,6-GlcNAc branch of N-glycans at the cell surface and of secreted glycoproteins, and functions as a positive regulator in glioma development, overview. As2O3-induced gioma cell apoptosis mechanism involves beta 1,4GalT V inhibition, overview
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beta-1,4-galactosylransferase participates in the synthesis of Galbeta1-4-GlcNac disaccharide unit of glycoconjugates, overview
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the specific inhibitors of the phosphatidylinositol 3-kinase LY294002 and wortmannin up-regulate beta1,4-galactosyltransferase I and thus sensitize SMMC-7721 human hepatocarcinoma cells to cycloheximide-induced apoptosis, overview
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beta4Gal-T1 participates in the synthesis of Galbeta1-4-GlcNac disaccharide unit of glycoconjugates
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LgtB is the beta-1,4-galactosyltransferase involved in the biosynthesis of the lipopolysaccharide O-chain backbone of Helicobacter pylori
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the enzyme is involved in regulation of carbohydrate composition of milk during lactation, endocrine enzyme regulation, overview
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beta-1,4-GalT I is a type II membrane-bound glycoprotein, which occurs the plasma membrane of different types of cells where it serves as a cell surface adhesion molecule mediating various cell-cell and cell-matrix interactions such as sperm-egg binding, cell spreading, migration, and neurite outgrowth
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additional information
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beta-1,4-GalT I is a type II membrane-bound glycoprotein, which occurs the plasma membrane of different types of cells where it serves as a cell surface adhesion molecule mediating various cell-cell and cell-matrix interactions such as sperm-egg binding, cell spreading, migration, and neurite outgrowth
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additional information
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beta-1,4-GalT-I plays a key role in the synthesis of selectin ligands such as sialy Lewis, sLex, and sulfated sLex, overview. beta-1,4-GalT-I may play an important role in the inflammation reaction
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2.4.1.38 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase
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