2.4.1.40: glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase
This is an abbreviated version!
For detailed information about glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase, go to the full flat file.
Word Map on EC 2.4.1.40
-
2.4.1.40
-
acetoacetate
-
acetobutylicum
-
succinyl-coenzyme
-
3-oxoacids
-
2.8.3.5
-
solventogenesis
-
acetoacetyl-coenzyme
-
synthesis
- 2.4.1.40
- acetoacetate
- acetobutylicum
-
succinyl-coenzyme
-
3-oxoacids
-
2.8.3.5
-
solventogenesis
-
acetoacetyl-coenzyme
- synthesis
Reaction
Synonyms
A transferase, A-transferase, ABO, ABO(H) blood group A glycosyltransferase, alpha-(1,3)-N-acetylgalactosaminyltransferase, alpha-3-N-acetylgalactosaminyltransferase, bacterial GTA, BgtA, blood group A glycosyltransferase, blood group A glycosyltransferase 2, blood-group substance A-dependent acetylgalactosaminyltransferase, blood-group substance alpha-acetyltransferase, cis-AB-transferase, fucosylgalactose acetylgalactosaminyltransferase, glycosyltransferases A, GTA, histo-blood group A acetylgalactosaminyltransferase, histo-blood group A glycosyltransferase (Fucalpha1-2Galalpha1-3-N-acetylgalactosaminyltransferase), histo-blood group A transferase, histo-blood group ABO system transferase, More, UDP-GalNAc:Fucalpha1-2Galalpha1-3-N-acetylgalactosaminyltransferase, UDP-N-acetyl-D-galactosamine:alpha-L-fucosyl-1,2-D-galactose 3-N-acetyl-D-galactosaminyltransferase
ECTree
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Reference on EC 2.4.1.40 - glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Marcus, S.L.; Polakowski, R.; Seto, N.O.L.; Leinala, E.; Borisova, S.; Blancher, A.; Roubinet, F.; Evans, S.V.; Palcic, M.M.
A single point mutation reverses the donor specificity of human blood group B-synthesizing galactosyltransferase
J. Biol. Chem.
278
12403-12405
2003
Homo sapiens (P16442)
Patenaude, S.I.; Seto, N.O.L.; Borisova, S.N.; Szpacenko, A.; Marcus, S.L.; Palcic, M.M.; Evans, S.V.
The structural basis for specificity in human ABO(H) blood group biosynthesis
Nat. Struct. Biol.
9
685-690
2002
Homo sapiens (P16442)
Yamamoto, M.; Lin, X.H.; Kominato, Y.; Hata, Y.; Noda, R.; Saitou, N.; Yamamoto, F.
Murine equivalent of the human histo-blood group ABO gene is a cis-AB gene and encodes a glycosyltransferase with both A and B transferase activity
J. Biol. Chem.
276
13701-13708
2001
Mus spicilegus, Mus musculus brevirostris (P38649), Mus musculus castaneus (P38649), Mus musculus domesticus (P38649), Mus musculus brevirostris BFM/2Msf (P38649), Mus spicilegus ZBN, Mus musculus domesticus BALB/c (P38649), Mus musculus castaneus CAST/Ei (P38649)
Seto, N.O.L.; Compston, C.A.; Szpacenko, A.; Palcic, M.M.
Enzymatic synthesis of blood group A and B trisaccharide analogues
Carbohydr. Res.
324
161-169
2000
Homo sapiens
Mukherjee, A.; Palcic, M.M.; Hindsgaul, O.
Synthesis and enzymatic evaluation of modified acceptors of recombinant blood group A and B glycosyltransferases
Carbohydr. Res.
326
1-21
2000
Homo sapiens
Seto, N.O.; Compston, C.A.; Evans, S.V.; Bundle, D.R.; Narang, S.A.; Palcic, M.M.
Donor substrate specificity of recombinant human blood group A, B and hybrid A/B glycosyltransferases expressed in Escherichia coli
Eur. J. Biochem.
259
770-775
1999
Homo sapiens
Seto, N.O.L.; Palcic, M.M.; Compston, C.A.; Li, H.; Bundle, D.R.; Narang, S.A.
Sequential interchange of four amino acids from blood group B to blood group A glycosyltransferase boosts catalytic activity and progressively modifies substrate recognition in human recombinant enzymes
J. Biol. Chem.
272
14133-14138
1997
Homo sapiens
Lowary, T.L.; Hindsgaul, O.
Recognition of synthetic O-methyl, epimeric, and amino analogues of the acceptor alpha-L-Fuc p-(1-2)-beta-D-Gal p-OR by the blood-group A and B gene-specified glycosyltransferases
Carbohydr. Res.
251
33-67
1994
Homo sapiens
Nakajima, T.; Furukawa, K.; Takenaka, O.
Blood group A and B glycosyltransferase in nonhuman primate plasma
Exp. Clin. Immunogenet.
10
21-30
1993
Macaca fascicularis, Homo sapiens, Pan troglodytes
Yazawa, S.; Nakajima, T.; Kameyama, N.; Saga, K.I.; Tachikawa, T.
An enzyme-linked immunosorbent assay for blood-group A and B enzymes
Carbohydr. Res.
239
329-335
1993
Homo sapiens
Cailleau-Thomas, A.; Le Moullac-Vaidye, B.; Rocher, J.; Bouhours, D.; Szpirer, C.; Le Pendu, J.
Cloning of a rat gene encoding the histo-blood group A enzyme. Tissue expression of the gene and of the A and B antigens
Eur. J. Biochem.
269
4040-4047
2002
Rattus norvegicus
Hirota, M.; Egami, H.; Ogawa, M.
Augmentation of UDP-GalNAc:Fuca1-2Gal-a1-3-N-acetylgalactosaminyl transferase activity in nitrosamine-induced hamster pancreatic cancers
J. Exp. Clin. Cancer Res.
19
235-239
2000
Mesocricetus auratus
David, L.; Leitao, D.; Sobrinho-Simoes, M.; Bennett, E.P.; White, T.; Mandel, U.; Dabelsteen, E.; Clausen, H.
Biosynthetic basis of incompatible histo-blood group A antigen expression: anti-A transferase antibodies reactive with gastric cancer tissue of type O individuals
Cancer Res.
53
5494-5500
1993
Homo sapiens
Navaratnam, N.; Findlay, J.B.C.; Keen, J.N.; Watkins, W.M.
Purification, properties and partial amino acid sequence of the blood-group-A-gene-associated alpha-3-N-acetylgalactosaminyltransferase from human gut mucosal tissue
Biochem. J.
271
93-98
1990
Homo sapiens
Takeya, A.; Hosomi, O.; Ishiura, M.
Complete purification and characterization of alpha-3-N-acetylgalactosaminyltransferase encoded by the human blood group A gene
J. Biochem.
107
360-368
1990
Homo sapiens
Clausen, H.; White, T.; Takio, K.; Titani, K.; Stroud, M.; Holmes, E.; Karkov, J.; Thim, L.; Hakomori, S.
Isolation to homogeneity and partial characterization of a histo-blood group A defined Fuc alpha 1-2Gal alpha 1-3-N-acetylgalactosaminyltransferase from human lung tissue
J. Biol. Chem.
265
1139-1145
1990
Homo sapiens
Nagai, M.; Dave, V.; Kaplan, B.E.; Yoshida, A.
Human blood group glycosyltransferases. I. Purification of N-acetylgalactosaminyltransferase
J. Biol. Chem.
253
377-379
1987
Homo sapiens
Schwyzer, M.; Hill, R.L.
Porcine A blood group-specific N-acetylgalactosaminyltransferase. I. Purification from porcine submaxillary glands
J. Biol. Chem.
252
2338-2345
1977
Sus scrofa
Kobata, A.; Grollman, E.F.; Ginsburg, V.
An enzymic basis for blood type A in humans
Arch. Biochem. Biophys.
124
609-612
1968
Homo sapiens
Turcot, A.L.; Blancher, A.; Le Moullac-Vaidye, B.; Despiau, S.; Rocher, J.; Roubinet, F.; Szpirer, C.; Le Pendu, J.
Cloning of a rat gene encoding the histo-blood group B enzyme: rats have more than one Abo gene
Glycobiology
13
919-928
2003
Rattus norvegicus (Q9ET32)
Nguyen, H.P.; Seto, N.O.L.; Cai, Y.; Leinala, E.K.; Borisova, S.N.; Palcic, M.M.; Evans, S.V.
The influence of an intramolecular hydrogen bond in differential recognition of inhibitory acceptor analogs by human ABO(H) blood group A and B glycosyltransferases
J. Biol. Chem.
278
49191-49195
2003
Homo sapiens (P16442)
Letts, J.A.; Rose, N.L.; Fang, Y.R.; Barry, C.H.; Borisova, S.N.; Seto, N.O.; Palcic, M.M.; Evans, S.V.
Differential recognition of the type I and II H antigen acceptors by the human ABO(H) blood group A and B glycosyltransferases
J. Biol. Chem.
281
3625-3632
2006
Homo sapiens (P16442), Homo sapiens
Alfaro, J.A.; Zheng, R.B.; Persson, M.; Letts, J.A.; Polakowski, R.; Bai, Y.; Borisova, S.N.; Seto, N.O.; Lowary, T.L.; Palcic, M.M.; Evans, S.V.
ABO(H) blood group A and B glycosyltransferases recognize substrate via specific conformational changes
J. Biol. Chem.
283
10097-10108
2008
Homo sapiens (P16442)
Yi, W.; Shen, J.; Zhou, G.; Li, J.; Wang, P.G.
Bacterial homologue of human blood group A transferase
J. Am. Chem. Soc.
130
14420-14421
2008
Helicobacter mustelae
Yamamoto, F.; Yamamoto, M.; Blancher, A.
Generation of histo-blood group B transferase by replacing the N-acetyl-D-galactosamine recognition domain of human A transferase with the galactose-recognition domain of evolutionarily related murine alpha1,3-galactosyltransferase
Transfusion
50
622-630
2009
Homo sapiens
Johal, A.; Schuman, B.; Alfaro, J.; Borisova, S.; Seto, N.; Evans, S.
Sequence-dependent effects of cryoprotectants on the active sites of the human ABO(H) blood group A and B glycosyltransferases
Acta Crystallogr. Sect. D
68
268-276
2012
Homo sapiens
Schuman, B.; Fisher, S.; Kovalevsky, A.; Borisova, S.; Palcic, M.; Coates, L.; Langan, P.; Evans, S.
Preliminary joint neutron time-of-flight and X-ray crystallographic study of human ABO(H) blood group A glycosyltransferase
Acta Crystallogr. Sect. F
67
258-262
2011
Homo sapiens (P16442), Homo sapiens
Grimm, L.; Weissbach, S.; Fluegge, F.; Begemann, N.; Palcic, M.; Peters, T.
Protein NMR studies of substrate binding to human blood group A and B glycosyltransferases
ChemBioChem
18
1260-1269
2017
Homo sapiens (P16442)
Fluegge, F.; Peters, T.
Insights into allosteric control of human blood group A and B glycosyltransferases from dynamic NMR
ChemistryOpen
8
760-769
2019
Homo sapiens (P16442)
Blackler, R.J.; Gagnon, S.M.; Polakowski, R.; Rose, N.L.; Zheng, R.B.; Letts, J.A.; Johal, A.R.; Schuman, B.; Borisova, S.N.; Palcic, M.M.; Evans, S.V.
Glycosyltransfer in mutants of putative catalytic residue Glu303 of the human ABO(H) A and B blood group glycosyltransferases GTA and GTB proceeds through a labile active site
Glycobiology
27
370-380
2017
Homo sapiens (P16442)
Gagnon, S.M.L.; Legg, M.S.G.; Sindhuwinata, N.; Letts, J.A.; Johal, A.R.; Schuman, B.; Borisova, S.N.; Palcic, M.M.; Peters, T.; Evans, S.V.
High-resolution crystal structures and STD NMR mapping of human ABO(H) blood group glycosyltransferases in complex with trisaccharide reaction products suggest a molecular basis for product release
Glycobiology
27
966-977
2017
Homo sapiens (P16442)
Gagnon, S.; Legg, M.; Polakowski, R.; Letts, J.; Persson, M.; Lin, S.; Zheng, R.; Rempel, B.; Schuman, B.; Haji-Ghassemi, O.; Borisova, S.; Palcic, M.; Evans, S.
Conserved residues Arg188 and Asp302 are critical for active site organization and catalysis in human ABO(H) blood group A and B glycosyltransferases
Glycobiology
28
624-636
2018
Homo sapiens (P16422)
Kano, T.; Kondo, K.; Hamako, J.; Matsushita, F.; Sakai, K.; Matsui, T.
Effects of plasma glycosyltransferase on the ABO(H) blood group antigens of human von Willebrand factor
Int. J. Hematol.
108
139-144
2018
Homo sapiens (P16442)
Fluegge, F.; Peters, T.
Complete assignment of Ala, Ile, Leu, Met and Val methyl groups of human blood group A and B glycosyltransferases using lanthanide-induced pseudocontact shifts and methyl-methyl NOESY
J. Biomol. NMR
70
245-259
2018
Homo sapiens (P16442)
Yamamoto, M.; Cid, E.; Yamamoto, F.
Crosstalk between ABO and Forssman (FORS) blood group systems FORS1 antigen synthesis by ABO gene-encoded glycosyltransferases
Sci. Rep.
7
41632
2017
Mus musculus (P38649)
Cid , E.; Yamamoto, M.; Yamamoto, F.
Amino acid substitutions at sugar-recognizing codons confer ABO blood group system-related alpha1,3 Gal(NAc) transferases with differential enzymatic activity
Sci. Rep.
9
846
2019
Homo sapiens (P16442)
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