2.4.1.41: polypeptide N-acetylgalactosaminyltransferase
This is an abbreviated version!
For detailed information about polypeptide N-acetylgalactosaminyltransferase, go to the full flat file.
Word Map on EC 2.4.1.41
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2.4.1.41
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o-glycosylation
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mucin-type
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mucin
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glycosyltransferase
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o-glycans
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o-linked
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threonine
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gangliosides
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lectin
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calcinosis
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oligosaccharide
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metastasis
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calcification
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hyperphosphatemic
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gm2
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galactosyltransferase
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glycolipids
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1,25-dihydroxyvitamin
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phosphaturic
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gd1a
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sialyltransferase
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submaxillary
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angptl3
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mucin-like
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klotho
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hyperostosis
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muc5ac
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factor-23
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apomucin
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analysis
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drug development
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lutropin
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asn-linked
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molecular biology
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periarticular
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medicine
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o-glycoproteins
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iga1
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villosa
- 2.4.1.41
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o-glycosylation
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mucin-type
- mucin
- glycosyltransferase
- o-glycans
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o-linked
- threonine
- gangliosides
- lectin
- calcinosis
- oligosaccharide
- metastasis
- calcification
-
hyperphosphatemic
- gm2
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galactosyltransferase
- glycolipids
-
1,25-dihydroxyvitamin
-
phosphaturic
- gd1a
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sialyltransferase
-
submaxillary
-
angptl3
-
mucin-like
- klotho
- hyperostosis
- muc5ac
-
factor-23
- apomucin
- analysis
- drug development
-
lutropin
-
asn-linked
- molecular biology
-
periarticular
- medicine
-
o-glycoproteins
- iga1
- villosa
Reaction
Synonyms
(UDP)-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase, acetylgalactosaminyltransferase, uridine diphosphoacetylgalactosamine-glycoprotein, bgibmga008904, dGalNAc-T3, Eg-ppGalNAc-T1, GalNAc transferase, GalNAc-T, GalNAc-T1, GalNAc-T11, GalNAc-T12, GalNAc-T13, GalNAc-T14, GalNAc-T16, GalNAc-T18, GalNAc-T2, GalNAc-T3, GalNAc-T4, GalNAc-T5, GalNAc-T6, GalNAc-T7, GalNAc-transferase, GalNAc-transferase T1, GalNAc-transferase T2, GalNAcT4, GALNT1, GALNT11, GALNT12, Galnt13, GALNT14, Galnt18, GALNT2, GALNT3, Galnt4, GalNT5, glycopeptide-preferring polypeptide GalNAc transferase 10, glycoprotein acetylgalactosaminyltransferase, More, N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyl-transferase, N-acetylgalactosaminyltransferase, N-acetylgalactosaminyltransferase-like 1, NM_001079884, PGANT, PGANT1, PGANT2, PGANT3, PGANT4, PGANT5, PGANT6, PGANT7, PGANT8, polypeptide GalNAc transferase, polypeptide GalNAc transferase 2, polypeptide GalNAc-transferase, polypeptide GalNAc-transferase 2, polypeptide GalNAc-transferase-2, polypeptide GalNAcT, polypeptide N-acetylgalactosaminyl transferase-3, polypeptide N-acetylgalactosaminyltransferase, polypeptide N-acetylgalactosaminyltransferase 12, polypeptide N-acetylgalactosaminyltransferase 14, polypeptide N-acetylgalactosaminyltransferase 2, polypeptide N-acetylgalactosaminyltransferase 3, polypeptide N-acetylgalactosaminyltransferase 6, polypeptide N-acetylgalactosaminyltransferase-1, polypeptide-N-acetylgalactosamine transferase, polyppetide GalNAc transferase, pp-GalNAc-T13, pp-GalNAc-T15, pp-GalNAc-T2, pp-GaNTase, ppGalNAc T1, ppGalNAc T10, ppGalNAc T13, ppGalNAc T16, ppGalNAc T2, ppGalNAc T3, ppGalNAc T5, ppGalNAc T6, ppGalNAc-T, ppGalNAc-T1, ppGalNAc-T10, ppGalNAc-T12, ppGalNAc-T2, ppGalNAc-T3, ppGalNAc-T4, ppGalNAc-T5, ppGalNAc-T6, ppGalNAcT, ppGalNAcT or hT, ppGaNTase, ppGaNTase-T1, ppGaNTase-T11, ppGaNTase-T12, ppGaNTase-T3, ppGaNTase-T4, ppGaNTase-T5, ppGaNTase-T6, protein-UDP acetylgalactosaminyltransferase, UDP GalNAc:polypeptide N-acetylgalactosaminyltransferase, UDP N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyl transferase, UDP N-acetyl-alpha-Dgalactosamine:polypeptide N-acetylgalactosaminyl transferase, UDP-acetylgalactosamine-glycoprotein acetylgalactosaminyltransferase, UDP-acetylgalactosamine:peptide-N-galactosaminyltransferase, UDP-GalNAc polypeptide:GalNAc transferase-T2, UDP-GalNAc polypeptide:N-acetylgalactosaminyltransferase, UDP-GalNAc polypeptides:N-acetyl-alpha-galactosaminyltransferase, UDP-GalNAc transferase, UDP-GalNAc:polypeptide alpha-N-acetylgalactosaminyltransferase, UDP-GalNAc:polypeptide alpha-N-acetylgalactosaminyltransferase-2, UDP-GalNAc:polypeptide alpha-N-acetylgalactosaminyltransferase-T1, UDP-GalNAc:polypeptide alphaN-acetylgalactosaminyltransferase, UDP-GalNAc:polypeptide GalNAc transferase, UDP-GalNAc:polypeptide N-acetylgalactosaminyl transferase, UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase, UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 18, UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 3, UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 9, UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-T3, UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase, UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1, UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13, UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13V1, UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 16, UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 17, UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 18, UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 19, UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 20, UDP-N-acetyl-alpha-D-galactosaminyltransferase, UDP-N-acetyl-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase-6, UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-T1, UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-T10, UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-T3, UDP-N-acetylgalactosamine polypeptide: N-acetylgalactosaminyl-transferase, UDP-N-acetylgalactosamine-glycoprotein N-acetylgalactosaminyltransferase, UDP-N-acetylgalactosamine-protein N-acetylgalactosaminyltransferase, UDP-N-acetylgalactosamine:kappa-casein polypeptide N-acetylgalactosaminyltransferase, UDP-N-acetylgalactosamine:polypeptide N-acetyl-alpha-galactosaminyltransferase, UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferase, UDP-N-acetylgalactosamine:protein N-acetylgalactosaminyl transferase, UDP-N-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase, UDP-polypeptide N-acetylgalactosaminyl transferase, uridine diphosphate-GalNAc:polypeptide N-acetylgalactosaminyltransferase 3, uridine diphosphoacetylgalactosamine-glycoprotein acetylgalactosaminyltransferase, xGaltnl-1
ECTree
2.4.1.41 polypeptide N-acetylgalactosaminyltransferaseAdvanced search results
results (
results (KM Value
KM Value on EC 2.4.1.41 - polypeptide N-acetylgalactosaminyltransferase
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KM VALUE [mM] 
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
1.3
Ac-Pro-Thr-Thr-Thr-Pro-Ile-Ser-Thr-NH2
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derived from the MUC2 repeat sequence
0.206
GT[GalNAc]TPSPVPTTST[GalNAc]TSAP
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pH not specified in the publication, 37°C
0.043
UDP-N-((2S)-2-azidopropanoyl)-alpha-D-galactosamine
mutant 253A/L310A, pH 7.4, 37°C
0.0026
UDP-N-hex-5-ynoyl-alpha-D-galactosamine
mutant 253A/L310A, pH 7.4, 37°C
3.3
Arg-Thr-Pro-Pro-Pro
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derived from the major acceptor sequence in myelin basic protein
16
GVVPTVVPG
+/-0.3 mM, mutant W316Y, 9.2 times higher than wild-type
17.6
GVVPTVVPG
+/-0.5 mM, mutant W316F, 10.1 times higher than wild-type
0.01
IgA hinge
+/-0.01 mM, mutant GalNAc-T2-D541A, pH7.4
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0.02
IgA hinge
+/-0.005 mM, mutant GalNAc-T2-D458H, pH7.4
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0.32
IgA hinge-4GalNAc
+/-0.09 mM, mutant GalNAc-T2-D541A, pH7.4
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0.81
IgA hinge-4GalNAc
+/-0.2 mM, mutant GalNAc-T2-D458H, pH7.4
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0.15
MUC1
+/-0.03 mM, mutant GalNAc-T2-D541A, pH7.4
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0.36
MUC1
+/-0.19mM, mutant GalNAc-T2-D458H, pH7.4
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0.86
MUC1-2GalNAc
+/-0.21 mM, mutant GalNAc-T2-D541A, pH7.4
0.018
Muc2
+/-0.003 mM, mutant GalNAc-T2-D541A, pH7.4
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0.25
Muc2
+/-0.006 mM, mutant GalNAc-T2-D458H, pH7.4
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0.066
MUC2-6GalNAc
+/-0.010 mM, mutant GalNAc-T2-D541A, pH7.4
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13.5
PPDAATAAPL
+/-0.7 mM, mutant W316Y, 38.5 times higher than wild-type
15.6
PPDAATAAPL
+/-0.6 mM, mutant W316F, 44.6 times higher than wild-type
0.036
UDP-Gal
+/-0.001 mM, mutant GalNAc-T2-D458H, pH7.4
0.041
UDP-Gal
+/-0.005 mM, mutant GalNAc-T2-D541A, pH7.4
0.013
UDP-GalNAc
+/-0.001 mM, mutant GalNAc-T2-D541A, pH7.4
0.03
UDP-GalNAc
+/-0.001 mM, mutant GalNAc-T2-D458H, pH7.4
0.16
UDP-GalNAc
determination of Km for UDP-GalNAc is performed with saturating concentration of CPPTPSATTPAPPSSSAPPETTAA as substrate. No incorporation is found with UDP-Gal or UDP-GlcNAc
6.2
UDP-GalNAc
+/-0.6 mM, mutant F325L, 1.2 times higher than wild-type
9
UDP-GalNAc
+/-0.1 mM, mutant W316Y, 1.8 times higher than wild-type
9.1
UDP-GalNAc
+/-0.7 mM, mutant W316F, 1.8 times higher than wild-type
14.2
UDP-GalNAc
+/-1.1 mM, mutant F303L, 2.8 times higher than wild-type
16
UDP-GalNAc
+/-0.3 mM, mutant Y309L, 3.2 times higher than wild-type
0.046
UDP-N-acetyl-alpha-D-galactosamine
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with polypeptide Muc2 as cosubstrate, at pH 6.0 and 37°C
0.016
UDP-N-acetyl-D-galactosamine
pH 7.4, 37°C, enzyme form pp-GalNAc-T15
0.081
UDP-N-acetyl-D-galactosamine
pH 7.4, 37°C, enzyme form pp-GalNAc-T2
additional information
apomucin
13.6 +/-1.9 mg/ml, mutant F303L, 2.8 times higher than wild-type
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additional information
apomucin
17.4 +/-3.6 mg/ml, mutant W316Y, 3.6 times higher than wild-type
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additional information
apomucin
4.7 +/-0.1 mg/ml, truncated wild-type P-T1/delta42
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additional information
apomucin
43.9 +/-3.8 mg/ml, mutant W316F, 9.1 times higher than wild-type
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additional information
apomucin
6.7 +/-1.7 mg/ml, mutant F325L, 1.4 times higher than wild-type
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additional information
apomucin
7.1 +/-0.4 mg/ml, mutant Y309L, 1.5 times higher than wild-type
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additional information
additional information
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Km: 2.5 mg/ml: deglycosylated bovine submaxillary mucin
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additional information
additional information
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Km: 1.01 mg/ml: ovine apomucin, 2.54 mg/ml: porcine apomucin
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additional information
additional information
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values for different human mucin Muc1 peptides
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additional information
additional information
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values for GalNAc-T1, -T2 and -T3 for different substrate peptides
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additional information
additional information
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effect of substrate glycosylation and amino acid substitution of glycopeptides on Km-values and enzyme activity
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additional information
additional information
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Km: 0.83 mg/ml: deglycosylated Cowper's gland mucin, 1.12 mg/ml: deglycosylated human trachea mucin, 0.94 mg/ml: deglycosylated swine trachea mucin, values for several tryptic peptides derived from them
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additional information
additional information
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increased values, mg/ml, for apomucin of several GalNAc-T1 mutants
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additional information
additional information
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Km: 0.192 mg/ml: apomucin, 1.15 mg/ml: kappa-subcomponent 1, 5.1 mg/ml: kappa-subcomponent 7
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additional information
additional information
KMs obtained using Lineweaver-Burk plot
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additional information
additional information
the KMs for apomucin and the synthetic peptides, PPDAATAAPL and GVVPTVVPG, were measured in presence of 7.5 µM UDP-GalNAc
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additional information
additional information
the KMs for UDP-GalNAc were measured in presence of 1.88 mg/ml apomucin
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