2.4.1.62: ganglioside galactosyltransferase

This is an abbreviated version!
For detailed information about ganglioside galactosyltransferase, go to the full flat file.

Word Map on EC 2.4.1.62

2.4.1.62

myelin

galactocerebroside

galactosylceramide

sulfatide

cerebroside

galactolipids

cgalt

beta1,3-galactosyltransferase

udp-glucose:ceramide

galcer

myelin-specific

2.4.1.45

galt-4

biotechnology

Reaction

an N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-acetylneuraminyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide

a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-acetylneuraminyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide

Synonyms

B3GALT4, beta 1,3-galactosyltransferase, beta3Gal-T, ceramide galactosyltransferase, ceramide galactosyltransferase UGT8, CGT, CgtB 11168, cgtBOH HS:10, cgtBOH4384, GA1/GM1/GD1b synthase, Gal-T2, galactosyltransferase, uridine diphosphogalactose-ceramide, GALT, GalT-3, GM1-synthase, UDP galactose-LAC Tet-ceramide alpha-galactosyltransferase, UDP-galactose-ceramide galactosyltransferase, UDP-galactose-GM2 galactosyltransferase, UDP-galactose-GM2 ganglioside galactosyltransferase, UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase, UDP-galactose:ceramide galactosyltransferase, UDP-galactose:GM2 ganglioside beta1-3 galactosyltransferase, UDP-galactose:N-acetylgalactosaminyl-(N-acetylneuraminyl) galactosyl-glucosyl-ceramide galactosyltransferase, uridine diphosphate D-galactose:glycolipid galactosyltransferase, uridine diphosphogalactose-ceramide galactosyltransferase, uridine diphosphogalactose-GM2 galactosyltransferase

ECTree

2 Transferases

2.4 Glycosyltransferases

2.4.1 Hexosyltransferases

2.4.1.62 ganglioside galactosyltransferase

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Results	in table
9	Activating Compound
12	AA Sequence
1	Application
1	CAS Registry Number
11	Cloned(Commentary)
55	Disease/ Diagnostics
3	Expression
3	General Information
1	General Stability
20	Inhibitors
15	KM Value [mM]
27	Localization
18	Metals/Ions
11	Molecular Weight [Da]
14	Natural Substrates/ Products (Substrates)
364	Organism
3	Pathway
5	pH Optimum
15	Posttranslational Modification
11	Protein Variants
3	Purification (Commentary)
1	Reaction
1	Reaction Type
31	Reference
33	Source Tissue
12	Specific Activity [micromol/min/mg]
1	Storage Stability
49	Substrates and Products (Substrate)
7	Subunits
45	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
3	Turnover Number [1/s]

Engineering

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Engineering on EC 2.4.1.62 - ganglioside galactosyltransferase

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Go to Protein Variants Search

DELTA20C

Campylobacter jejuni

Q0P9B5, Q93MQ1, Q9K2V8

mutant with deletion of 20 amino acids from carboxy terminus + C-terminal MalE fusion, specific activity (mU/mg): 58.1 (substrate: GalNAcalpha), 127.5 (substrate: GalNAcbeta), 17.5 (substrate: GM2), 374 (substrate: GA2)

692522

DELTA20N

Campylobacter jejuni

Q0P9B5, Q93MQ1, Q9K2V8

mutant with deletion of 20 amino acids from carboxy terminus + N-terminal MalE fusion, specific activity (mU/mg): 3.3 (substrate: GalNAcalpha), 8.0 (substrate: GalNAcbeta), 2.3 (substrate: GM2), 34.4 (substrate: GA2)

DELTA30C

DELTA30N

D175A

overexpression of the mutant and -D291A does not rescue galactosylation deficiency of a knockout strain

757755

D176A

Homo sapiens

O96024

overexpression of the mutant and -D291A does not rescue galactosylation deficiency of a knockout strain

757755

D177A

Homo sapiens

O96024

overexpression of the mutant and -D291A does not rescue galactosylation deficiency of a knockout strain

757755

additional information

3 entries