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2.4.1.62: ganglioside galactosyltransferase

This is an abbreviated version!
For detailed information about ganglioside galactosyltransferase, go to the full flat file.

Word Map on EC 2.4.1.62

Reaction

UDP-alpha-D-galactose
+
an N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-acetylneuraminyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
=
UDP
 +
a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-acetylneuraminyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide

Synonyms

B3GALT4, beta 1,3-galactosyltransferase, beta3Gal-T, ceramide galactosyltransferase, ceramide galactosyltransferase UGT8, CGT, CgtB 11168, cgtBOH HS:10, cgtBOH4384, GA1/GM1/GD1b synthase, Gal-T2, galactosyltransferase, uridine diphosphogalactose-ceramide, GALT, GalT-3, GM1-synthase, UDP galactose-LAC Tet-ceramide alpha-galactosyltransferase, UDP-galactose-ceramide galactosyltransferase, UDP-galactose-GM2 galactosyltransferase, UDP-galactose-GM2 ganglioside galactosyltransferase, UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase, UDP-galactose:ceramide galactosyltransferase, UDP-galactose:GM2 ganglioside beta1-3 galactosyltransferase, UDP-galactose:N-acetylgalactosaminyl-(N-acetylneuraminyl) galactosyl-glucosyl-ceramide galactosyltransferase, uridine diphosphate D-galactose:glycolipid galactosyltransferase, uridine diphosphogalactose-ceramide galactosyltransferase, uridine diphosphogalactose-GM2 galactosyltransferase

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.1 Hexosyltransferases
                2.4.1.62 ganglioside galactosyltransferase

Reference

topprint

Reference on EC 2.4.1.62 - ganglioside galactosyltransferase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Tencomnao, T.; Yu, R.K.; Kapitonov, D.
Characterization of the human UDP-galactose:ceramide galactosyltransferase gene promoter
Biochim. Biophys. Acta
1517
416-423
2001
Homo sapiens
Manually annotated by BRENDA team
Schulte, S.; Stoffel, W.
UDP galactose:ceramide galactosyltransferase and glutamate/aspartate transporter. Copurification, separation and characterization of the two glycoproteins
Eur. J. Biochem.
233
947-953
1995
Rattus norvegicus, Rattus norvegicus Wistar
Manually annotated by BRENDA team
Sanyal, S.N.
Stimulation of uridine diphosphate-galactose: ceramide galactosyl transferase by certain soluble protein factor in rat brain cytosol
Indian J. Exp. Biol.
25
606-612
1987
Rattus norvegicus
Manually annotated by BRENDA team
Neskovic, N.M.; Mandel, P.; Gatt, S.
UDP-galactose: ceramide galactosyltransferase. Kinetic properties and effect of detergents and phospholipids on the partially purified enzyme of rat brain
Adv. Exp. Med. Biol.
101
613-630
1978
Rattus norvegicus
Manually annotated by BRENDA team
Basu, S.; Kaufman, B.; Roseman, S.
Conversion of Tay-Sachs ganglioside to monosialoganglioside by brain uridine diphosphate D-galactose: glycolipid galactosyltransferase
J. Biol. Chem.
240
4115-4117
1965
Gallus gallus, Rattus norvegicus, Sus scrofa
Manually annotated by BRENDA team
Yip, M.C.M.; Dain, J.A.
Frog brain uridine diphosphate galactose-N-acetylgalactosaminyl-N-acetylneuraminylgalactosylglucosylceramide galactosyltransferase
Biochem. J.
118
247-252
1970
Lithobates pipiens
Manually annotated by BRENDA team
Bellman Yip, G.; Dain, J.A.
The enzymic synthesis of ganglioside. II. UDP-galactose: N-acetylgalactosaminyl-(N-acetylneuraminyl)galactosyl-glucosyl-ceramide galactosyltransferase in rat brain
Biochim. Biophys. Acta
206
252-260
1970
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Manually annotated by BRENDA team
Senn, H.J.; Wagner, M.; Decker, K.
Ganglioside biosynthesis in rat liver. Characterization of UDPgalactose--glucosylceramide galactosyltransferase and UDPgalactose-GM2 galactosyltransferase
Eur. J. Biochem.
135
231-236
1983
Rattus norvegicus
Manually annotated by BRENDA team
Costantino-Ceccarini, E.; Suzuki, K.
Isolation and partial characterization of an endogenous inhibitor of ceramide glycosyltransferases from rat brain
J. Biol. Chem.
253
340-342
1978
Rattus norvegicus
Manually annotated by BRENDA team
Stahl, N.; Jurevics, H.; Morell, P.; Suzuki, K.; Popko, B.
Isolation, characterization, and expression of cDNA clones that encode rat UDP-galactose:ceramide galactosyltransferase
J. Neurosci. Res.
38
234-242
1994
Rattus norvegicus
Manually annotated by BRENDA team
Ghosh, S.; Kyle, J.W.; Dastgheib, S.; Daussin, F.; Li, Z.; Basu, S.
Purification, properties, and immunological characterization of GalT-3 (UDP-galactose: GM2 ganglioside, beta1-3 galactosyltransferase) from embryonic chicken brain
Glycoconjugate J.
12
838-847
1995
Gallus gallus
Manually annotated by BRENDA team
Sprong, H.; Kruithof, B.; Leijendekker, R.; Slot, J.W.; Van Meer, G.; Van Der Sluijs, P.
UDP-galactose:ceramide galactosyltransferase is a class I integral membrane protein of the endoplasmic reticulum
J. Biol. Chem.
273
25880-25888
1998
no activity in Mesocricetus auratus, Rattus norvegicus
Manually annotated by BRENDA team
Amado, M.; Almeida, R.; Carneiro, F.; Levery, S.B.; Holmes, E.H.; Nomoto, M.; Hollingsworth, M.A.; Hassan, H.; Schwientek, T.; Nielsen, P.A.; Bennett, E.P.; Clausen, H.
A family of human beta3-galactosyltransferases. Characterization of four members of a UDP-galactose:beta-N-acetyl-glucosamine/beta-acetyl-galactosamine beta-1,3-galactosyltransferase family
J. Biol. Chem.
273
12770-12778
1998
Homo sapiens (O43825), Homo sapiens (O75752), Homo sapiens (O96024), Drosophila melanogaster (Q24157)
Manually annotated by BRENDA team
Daniotti, J.L.; Martina, J.A.; Zurita, A.R.; Maccioni, H.J.
Mouse beta 1,3-galactosyltransferase (GA1/GM1/GD1b synthase): protein characterization, tissue expression, and developmental regulation in neural retina
J. Neurosci. Res.
58
318-327
1999
Mus musculus (Q9Z0F0), Mus musculus
Manually annotated by BRENDA team
Martina, J.A.; Daniotti, J.L.; Maccioni, H.J.
GM1 synthase depends on N-glycosylation for enzyme activity and trafficking to the Golgi complex
Neurochem. Res.
25
725-731
2000
Mus musculus (Q9Z0F0), Mus musculus
Manually annotated by BRENDA team
Paul, P.; Lutz, T.M.; Osborn, C.; Kyosseva, S.; Elbein, A.D.; Towbin, H.; Radominska, A.; Drake, R.R.
Synthesis and characterization of a new class of inhibitors of membrane-associated UDP-glycosyltransferases
J. Biol. Chem.
268
12933-12938
1993
Mus musculus
Manually annotated by BRENDA team
Fewou, S.N.; Bussow, H.; Schaeren-Wiemers, N.; Vanier, M.T.; Macklin, W.B.; Gieselmann, V.; Eckhardt, M.
Reversal of non-hydroxy:alpha-hydroxy galactosylceramide ratio and unstable myelin in transgenic mice overexpressing UDP-galactose:ceramide galactosyltransferase
J. Neurochem.
94
469-481
2005
Rattus norvegicus
Manually annotated by BRENDA team
Franken, S.; Wittke, D.; Mansson, J.E.; DHooge, R.; De Deyn, P.P.; Luellmann-Rauch, R.; Matzner, U.; Gieselmann, V.
Modest phenotypic improvements in ASA-deficient mice with only one UDP-galactose:ceramide-galactosyltransferase gene
Lipids Health Dis.
5
21
2006
Mus musculus
Manually annotated by BRENDA team
Bernatchez, S.; Gilbert, M.; Blanchard, M.C.; Karwaski, M.F.; Li, J.; Defrees, S.; Wakarchuk, W.W.
Variants of the beta 1,3-galactosyltransferase CgtB from the bacterium Campylobacter jejuni have distinct acceptor specificities
Glycobiology
17
1333-1343
2007
Campylobacter jejuni (Q0P9B5), Campylobacter jejuni (Q93MQ1), Campylobacter jejuni (Q9K2V8), Campylobacter jejuni
Manually annotated by BRENDA team
Saadat, L.; Dupree, J.L.; Kilkus, J.; Han, X.; Traka, M.; Proia, R.L.; Dawson, G.; Popko, B.
Absence of oligodendroglial glucosylceramide synthesis does not result in CNS myelin abnormalities or alter the dysmyelinating phenotype of CGT-deficient mice
Glia
58
391-398
2010
Mus musculus
Manually annotated by BRENDA team
Niimura, Y.; Moue, T.; Takahashi, N.; Nagai, K.I.
Modification of sphingoglycolipids and sulfolipids in kidney cell lines under heat stress: Activation of monohexosylceramide synthesis as a ceramide scavenger
Glycobiology
20
710-717
2010
Chlorocebus aethiops, Canis lupus familiaris
Manually annotated by BRENDA team
Dziegiel, P.; Owczarek, T.; Plazuk, E.; Gomulkiewicz, A.; Majchrzak, M.; Podhorska-Okolow, M.; Driouch, K.; Lidereau, R.; Ugorski, M.
Ceramide galactosyltransferase (UGT8) is a molecular marker of breast cancer malignancy and lung metastases
Br. J. Cancer
103
524-531
2010
Homo sapiens
Manually annotated by BRENDA team
Hayashi, T.; Hayashi, E.; Fujimoto, M.; Sprong, H.; Su, T.P.
The lifetime of UDP-galactose:ceramide galactosyltransferase is controlled by a distinct endoplasmic reticulum-associated degradation (ERAD) regulated by sigma-1 receptor chaperones
J. Biol. Chem.
287
43156-43169
2012
Rattus norvegicus
Manually annotated by BRENDA team
Wang, Y.; Maeda, Y.; Liu, Y.S.; Takada, Y.; Ninomiya, A.; Hirata, T.; Fujita, M.; Murakami, Y.; Kinoshita, T.
Cross-talks of glycosylphosphatidylinositol biosynthesis with glycosphingolipid biosynthesis and ER-associated degradation
Nat. Commun.
11
860
2020
Homo sapiens (O96024)
Manually annotated by BRENDA team