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2.4.1.65: 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase

This is an abbreviated version!
For detailed information about 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase, go to the full flat file.

Word Map on EC 2.4.1.65

Reaction

GDP-beta-L-fucose
+
beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-R
=
GDP
+
beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl-R

Synonyms

(Lea)-dependent alpha-3/4-fucosyltransferase, alpha 1,3-fucosyltransferase VII, alpha 1,3/4 fucosyltransferase, alpha(1,3) fucosyltransferase, alpha(1,3/1,4) fucosyltransferase III, alpha(1,3/4) fucosyltransferase, alpha(1,3/4)-FUT, alpha-(1,3/1,4)-fucosyltransferase, alpha-(1,3/1,4)-FucT, alpha-(1-3/4)-fucosyltransferase, alpha-(1->4)-L-fucosyltransferase, alpha-1,3 fucosyltransferase, alpha-1,3-fucosyltransferase, alpha-1,3/4-fucosyltransferase, alpha-1,3fucosyltransferase, alpha-1,4 fucosyltransferase, alpha-3-FUT, alpha-3/4 fucosyltransferase, alpha-3/4 fucosyltransferase III, alpha-3/4-FUT, alpha-4-fucosyltransferase, alpha-4-L-fucosyltransferase, alpha1,3 fucosyltransferase, alpha1,3 fucosyltransferase VII, alpha1,3-fucosyltransferase, alpha1,3-fucosyltransferase IX, alpha1,3-fucosyltransferase VI, alpha1,3/1,4FucT III, alpha1,3/4-fucosyltransferase, alpha1,3/4-fucosyltransferase VI, alpha1,3/4-fucosyltransferases-V and -VI, alpha1,3/4-FUT, alpha1,3FucT IV, alpha1,3FucT IX, alpha1,3FucT V, alpha1,3FucT VI, alpha1,3FucT VII, alpha3/4 fucosyltransferase 3, alpha3/4 fucosyltransferases, alpha3/4FucT, alpha4-fucosyltransferase, alpha4-FucT, alphaFucT, beta-acetylglucosaminylsaccharide fucosyltransferase, blood group Lewis alpha-4-fucosyltransferase, blood-group substance Lea-dependent fucosyltransferase, FT-IV, FT-VII, FT3, FT6, FT7, Fuc-T, Fuc-TIII, fucosyltransferase, fucosyltransferase 3, fucosyltransferase 5, fucosyltransferase 6, fucosyltransferase 7, fucosyltransferase IV, fucosyltransferase V, fucosyltransferase VI, fucosyltransferase VII, fucosyltransferase, guanosine diphosphofucose-beta-acetylglucosaminylsaccharide 4-alpha-L-, fucosyltransferase, guanosine diphosphofucose-glycoprotein 4-alpha-, FucT, FucT III, FucT IV, FucT IX, FucT V, FucT VI, FucT VII, FucT-II, FucT-III, FucT-V, FucT-VI, FucT-VII, FucTIII, FUT III, FUT10, FUT11, Fut13, FUT3, FUT4, FUT5, FUT6, FUT7, Fut9, GDP-Fuc: beta-D-Galp-(1-3/4)-beta-D-GlcpNAc-(1-4'/3')-alpha-fucosyltransferase, guanosine diphosphofucose-glycoprotein 4-alpha-L-fucosyltransferase, Lewis alpha-3-fucosyltransferase, Lewis alpha-3/4-fucosyltransferase, Lewis alpha1-3/4 fucosyltransferase, Lewis blood group alpha1-3/4 fucosyltransferase, Lewis(Le) blood group gene-dependent alpha-3/4-L-fucosyltransferase, SFT3, sFUT5, sperm fucosyltransferase-5, UA948FucT

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.1 Hexosyltransferases
                2.4.1.65 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase

KI Value

KI Value on EC 2.4.1.65 - 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0007 - 0.0022
(-)-epigallocatechin-3-gallate
7
2'-fucosyllactose
-
-
0.115
2,5-dihydroxybenzoic acid
presence of MnCl2, overnight (15 h) pre-incubation of compound and enzyme before initiation of the reaction with GDP-fucose
0.00006 - 0.008
3,4,5-Trihydroxybenzoic acid
0.137
3,4-dihydroxybenzoic acid
presence of MnCl2, overnight (15 h) pre-incubation of compound and enzyme before initiation of the reaction with GDP-fucose
17
4-O-beta-D-galactopyranosyl-D-glucitol
-
-
0.889
C-fucosyl analogon of GDP-fucose
-
-
0.0671
carba-fucosyl analogon of GDP-fucose
-
-
0.0503
dGDP
-
at pH 4.5 and 37°C
0.0012
ellagic acid
presence of MnCl2, overnight (15 h) pre-incubation of compound and enzyme before initiation of the reaction with GDP-fucose
0.0779
GDP
-
at pH 4.5 and 37°C
0.102
GDP-6-amino-beta-L-fucose
-
at pH 4.5 and 37°C
0.0807
GTP
-
at pH 4.5 and 37°C
0.6
lacto-N-fucopentaitol I
-
-
0.008
methyl gallate
presence of MnCl2, overnight (15 h) pre-incubation of compound and enzyme before initiation of the reaction with GDP-fucose
0.25
NEM
-
enzyme form FTA and FTB
0.045
propyl gallate
presence of MnCl2, overnight (15 h) pre-incubation of compound and enzyme before initiation of the reaction with GDP-fucose
0.0256
unsaturated carba-fucosyl analogon of GDP-fucose
-
-
-
0.19
[1-(beta-D-fucopyranosyl)-1H-1,2,3-triazole-4-yl]methylguanosine diphosphate
-
at pH 4.5 and 37°C
0.186
[1-(beta-D-galactopyranosyl)-1H-1,2,3-triazole-4-yl] methylguanosine diphosphate
-
at pH 4.5 and 37°C
0.137
[1-(beta-L-fucopyranosyl)-1H-1,2,3-triazole-4-yl]methylguanosine diphosphate
-
at pH 4.5 and 37°C
additional information
additional information
2,3-dihydroxybenzoic acid: above 0.200, presence of MnCl2, overnight (15 h) pre-incubation of compound and enzyme before initiation of the reaction with GDP-fucose, 2,4-dihydroxybenzoic acid: above 0.200, presence of MnCl2, overnight (15 h) pre-incubation of compound and enzyme before initiation of the reaction with GDP-fucose, 3,5-dimethoxy 4-hydroxybenzoic acid: above 0.200, presence of MnCl2, overnight (15 h) pre-incubation of compound and enzyme before initiation of the reaction with GDP-fucose, 3,4-dimethoxybenzoic acid: above 0.200, presence of MnCl2, overnight (15 h) pre-incubation of compound and enzyme before initiation of the reaction with GDP-fucose, 3,4,5-trimethoxybenzoic acid: above 0.200, presence of MnCl2, overnight (15 h) pre-incubation of compound and enzyme before initiation of the reaction with GDP-fucose
-