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2.4.1.65: 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase

This is an abbreviated version!
For detailed information about 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase, go to the full flat file.

Word Map on EC 2.4.1.65

Reaction

GDP-beta-L-fucose
+
beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-R
=
GDP
 +
beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl-R

Synonyms

(Lea)-dependent alpha-3/4-fucosyltransferase, alpha 1,3-fucosyltransferase VII, alpha 1,3/4 fucosyltransferase, alpha(1,3) fucosyltransferase, alpha(1,3/1,4) fucosyltransferase III, alpha(1,3/4) fucosyltransferase, alpha(1,3/4)-FUT, alpha-(1,3/1,4)-fucosyltransferase, alpha-(1,3/1,4)-FucT, alpha-(1-3/4)-fucosyltransferase, alpha-(1->4)-L-fucosyltransferase, alpha-1,3 fucosyltransferase, alpha-1,3-fucosyltransferase, alpha-1,3/4-fucosyltransferase, alpha-1,3fucosyltransferase, alpha-1,4 fucosyltransferase, alpha-3-FUT, alpha-3/4 fucosyltransferase, alpha-3/4 fucosyltransferase III, alpha-3/4-FUT, alpha-4-fucosyltransferase, alpha-4-L-fucosyltransferase, alpha1,3 fucosyltransferase, alpha1,3 fucosyltransferase VII, alpha1,3-fucosyltransferase, alpha1,3-fucosyltransferase IX, alpha1,3-fucosyltransferase VI, alpha1,3/1,4FucT III, alpha1,3/4-fucosyltransferase, alpha1,3/4-fucosyltransferase VI, alpha1,3/4-fucosyltransferases-V and -VI, alpha1,3/4-FUT, alpha1,3FucT IV, alpha1,3FucT IX, alpha1,3FucT V, alpha1,3FucT VI, alpha1,3FucT VII, alpha3/4 fucosyltransferase 3, alpha3/4 fucosyltransferases, alpha3/4FucT, alpha4-fucosyltransferase, alpha4-FucT, alphaFucT, beta-acetylglucosaminylsaccharide fucosyltransferase, blood group Lewis alpha-4-fucosyltransferase, blood-group substance Lea-dependent fucosyltransferase, FT-IV, FT-VII, FT3, FT6, FT7, Fuc-T, Fuc-TIII, fucosyltransferase, fucosyltransferase 3, fucosyltransferase 5, fucosyltransferase 6, fucosyltransferase 7, fucosyltransferase IV, fucosyltransferase V, fucosyltransferase VI, fucosyltransferase VII, fucosyltransferase, guanosine diphosphofucose-beta-acetylglucosaminylsaccharide 4-alpha-L-, fucosyltransferase, guanosine diphosphofucose-glycoprotein 4-alpha-, FucT, FucT III, FucT IV, FucT IX, FucT V, FucT VI, FucT VII, FucT-II, FucT-III, FucT-V, FucT-VI, FucT-VII, FucTIII, FUT III, FUT10, FUT11, Fut13, FUT3, FUT4, FUT5, FUT6, FUT7, Fut9, GDP-Fuc: beta-D-Galp-(1-3/4)-beta-D-GlcpNAc-(1-4'/3')-alpha-fucosyltransferase, guanosine diphosphofucose-glycoprotein 4-alpha-L-fucosyltransferase, Lewis alpha-3-fucosyltransferase, Lewis alpha-3/4-fucosyltransferase, Lewis alpha1-3/4 fucosyltransferase, Lewis blood group alpha1-3/4 fucosyltransferase, Lewis(Le) blood group gene-dependent alpha-3/4-L-fucosyltransferase, SFT3, sFUT5, sperm fucosyltransferase-5, UA948FucT

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.1 Hexosyltransferases
                2.4.1.65 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase

KM Value

KM Value on EC 2.4.1.65 - 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.12 - 2.7
(Gal-3-O-Me)beta(1-3)(GlcNAc-6-O-Me)beta-O-Me
11
2'-fucosyllactose
-
-
0.16 - 0.4
2-O-MeGalbeta(1,3)GlcNAcbeta-O-Bn
0.047 - 0.1
3-O-sulfoGalbeta(1,3)GlcNAcbeta-O-Al
0.045
ancrod
-
enzyme form FTB
-
0.167
asialo ancrod
-
enzyme form FTB
-
0.63
fetuin triantennary asialoglycopeptide
-
enzyme form FTB
-
1.43
fetuin triantennary glycopeptide
-
enzyme form FTB
-
0.075 - 1.3
Formic acid (2R,3R,4S,5R,6R)-2-((2R,3R,4R,5R,6R)-3-acetylamino-5-hydroxy-2-methoxy-6-methylaminomethyl-tetrahydro-pyran-4-yloxy)-4,5-dihydroxy-6-hydroxymethyl-tetrahydro-pyran-3-yl ester
0.2 - 2.5
Fuc-alpha-1,2Gal-beta-1,3GlcNAc-sp-biotin
0.1 - 1.3
Fuc-alpha-1,2Gal-beta-1,4GlcNAc-sp-biotin
0.14
Fuc-alpha1-2Galbeta1-4GlcNAc-octyl
-
-
0.1 - 3.8
Fucalpha(1,2)Galbeta(1,3)GlcNAc
0.8
Fucalpha(1,2)Galbeta(1,3)GlcNAcbeta(1,3)Galbeta(1,4)Glc
-
-
1.52
Fucalpha(1,2)Galbeta(1,4)Glc
-
enzyme form FTB
0.5 - 0.7
Fucalpha(1,2)Galbeta(1,4)GlcNAc
8.4 - 22.7
Gal-beta-1,3-GlcNAc-O-(CH2)8CO2CH3
0.7 - 3.3
Gal-beta-1,3GlcNAcO(CH2)3NHCO(CH2)5NH-biotin
0.17 - 2.2
Gal-beta-1,4-GlcNAc-O-(CH2)8CO2CH3
0.6 - 12.7
Galbeta(1,3)GlcNAc
0.76 - 0.87
Galbeta(1,3)GlcNAc-(CH2)3-NHCO-(CH2)5-NH-biotin
2.4
Galbeta(1,3)GlcNAcbeta(1,3)Galbeta(1,4)Glc
-
-
0.012
Galbeta(1,4)(5-thioGlc)
-
-
0.5
Galbeta(1,4)Glc
-
-
0.035 - 8.1
Galbeta(1,4)GlcNAc
0.4
Galbeta(1,4)GlcNAcbeta(1,2)Man
-
-
3.8
Galbeta(1,4)GlcNAcbeta(1,3)Galbeta(1,4)Glc
-
-
0.016
Galbeta(1,4)GlcNAcbetaOallyl
-
-
0.034
Galbeta(1,4)Glucal
-
-
12
Galbeta(1,6)Galbeta(1,4)Glc
-
-
0.35 - 1.2
Galbeta(1-3)GlcNAcbeta-O-Me
0.114
Galbeta-1,3GlcNAc-R
37°C, pH 6.5
5.7 - 13.3
Galbeta1,3GlcNAc-O(CH2)8CO2CH3
3.6
Galbeta1-4GlcNAc-4-nitrophenyl
-
-
3.8
GalNAcbeta1-4GlcNAc-diaminopimelyl
-
-
0.27
GalNAcbeta1-4GlcNAc-octyl
-
-
0.016
GDP
-
-
0.00573 - 0.0337
GDP-beta-L-fucose
0.1145
GDP-D-fucose
-
mutant enzyme D336A
0.03 - 0.244
GDP-fucose
0.005 - 0.035
GDP-L-fucose
0.15 - 0.154
GlcNAcbeta(1-2)Manalpha(1-6)[GlcNAcbeta(1-2)Manalpha(1-3)]Manbeta(1-4)GlcNAcbeta(1-4)GlcNAcbeta(1-)AspNHCO-biotin
0.06
GMP
-
-
3 - 25
N-((1R,3R,5R,6R,7S,8R,13R,15R,16R,17S)-6,7,17-trihydroxy-5-hydroxymethyl-15-methoxy-2,4,9,11,14-pentaoxa-tricyclo[11.3.1.0 3,8]heptadec-16-yl)-acetamide
1.1 - 11
N-((1R,3R,5R,6R,7S,8R,13R,15R,16R,17S)-6,7,17-Trihydroxy-5-hydroxymethyl-15-methoxy-2,4,9,11,14-pentaoxa-tricyclo[11.3.1.03,8]heptadec-16-yl)-acetamide
0.61 - 16
N-((1R,3R,5R,6R,7S,8R,14R,16R,17R,18R)-6,7,18-trihydroxy-5-hydroxymethyl-16-methoxy-11-oxo-2,4,9,15-tetraoxa-12-aza-tricyclo[12.3.1.03,8]octadec-17-yl)-acetamide
0.4 - 5
N-((1R,3R,5R,6R,7S,8R,14R,16R,17R,18S)-6,7,18-Trihydroxy-5-hydroxymethyl-16-methoxy-2,4,9,12,15-pentaoxa-tricyclo[12.3.1.03,8]octadec-17-yl)-acetamide
0.67 - 2.5
NeuAcalpha(2,3)Galbeta(1,3)GlcNAcbeta-O-Bn
0.1 - 0.28
NeuAcalpha(2,3)Galbeta(1,4)GlcNAc
0.77 - 3.3
NeuAcalpha(2,3)Galbeta(1,4)GlcNAcbeta(1,6)(Galbeta(1,3))GalNAcalpha-OMe
0.064
NeuAcalpha(2,3)Galbeta(1,4)Glucal
-
-
0.07
NeuAcalpha(2,6)Galbeta(1,4)GlcNAc
-
-
0.111
Siaalpha-2,3Galbeta-1,3GlcNAc-R
37°C, pH 6.5