2.4.1.65: 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase

This is an abbreviated version!
For detailed information about 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase, go to the full flat file.

Reaction

Synonyms

(Lea)-dependent alpha-3/4-fucosyltransferase, alpha 1,3-fucosyltransferase VII, alpha 1,3/4 fucosyltransferase, alpha(1,3) fucosyltransferase, alpha(1,3/1,4) fucosyltransferase III, alpha(1,3/4) fucosyltransferase, alpha(1,3/4)-FUT, alpha-(1,3/1,4)-fucosyltransferase, alpha-(1,3/1,4)-FucT, alpha-(1-3/4)-fucosyltransferase, alpha-(1->4)-L-fucosyltransferase, alpha-1,3 fucosyltransferase, alpha-1,3-fucosyltransferase, alpha-1,3/4-fucosyltransferase, alpha-1,3fucosyltransferase, alpha-1,4 fucosyltransferase, alpha-3-FUT, alpha-3/4 fucosyltransferase, alpha-3/4 fucosyltransferase III, alpha-3/4-FUT, alpha-4-fucosyltransferase, alpha-4-L-fucosyltransferase, alpha1,3 fucosyltransferase, alpha1,3 fucosyltransferase VII, alpha1,3-fucosyltransferase, alpha1,3-fucosyltransferase IX, alpha1,3-fucosyltransferase VI, alpha1,3/1,4FucT III, alpha1,3/4-fucosyltransferase, alpha1,3/4-fucosyltransferase VI, alpha1,3/4-fucosyltransferases-V and -VI, alpha1,3/4-FUT, alpha1,3FucT IV, alpha1,3FucT IX, alpha1,3FucT V, alpha1,3FucT VI, alpha1,3FucT VII, alpha3/4 fucosyltransferase 3, alpha3/4 fucosyltransferases, alpha3/4FucT, alpha4-fucosyltransferase, alpha4-FucT, alphaFucT, beta-acetylglucosaminylsaccharide fucosyltransferase, blood group Lewis alpha-4-fucosyltransferase, blood-group substance Lea-dependent fucosyltransferase, FT-IV, FT-VII, FT3, FT6, FT7, Fuc-T, Fuc-TIII, fucosyltransferase, fucosyltransferase 3, fucosyltransferase 5, fucosyltransferase 6, fucosyltransferase 7, fucosyltransferase IV, fucosyltransferase V, fucosyltransferase VI, fucosyltransferase VII, fucosyltransferase, guanosine diphosphofucose-beta-acetylglucosaminylsaccharide 4-alpha-L-, fucosyltransferase, guanosine diphosphofucose-glycoprotein 4-alpha-, FucT, FucT III, FucT IV, FucT IX, FucT V, FucT VI, FucT VII, FucT-II, FucT-III, FucT-V, FucT-VI, FucT-VII, FucTIII, FUT III, FUT10, FUT11, Fut13, FUT3, FUT4, FUT5, FUT6, FUT7, Fut9, GDP-Fuc: beta-D-Galp-(1-3/4)-beta-D-GlcpNAc-(1-4'/3')-alpha-fucosyltransferase, guanosine diphosphofucose-glycoprotein 4-alpha-L-fucosyltransferase, Lewis alpha-3-fucosyltransferase, Lewis alpha-3/4-fucosyltransferase, Lewis alpha1-3/4 fucosyltransferase, Lewis blood group alpha1-3/4 fucosyltransferase, Lewis(Le) blood group gene-dependent alpha-3/4-L-fucosyltransferase, SFT3, sFUT5, sperm fucosyltransferase-5, UA948FucT

ECTree

     2 Transferases

         2.4 Glycosyltransferases

             2.4.1 Hexosyltransferases

                2.4.1.65 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase

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Results	in table
2	Activating Compound
28	AA Sequence
5	Application
1	CAS Registry Number
27	Cloned(Commentary)
286	Disease/ Diagnostics
5	Expression
14	General Information
11	IC50 Value
62	Inhibitors
26	Ki Value [mM]
121	KM Value [mM]
33	Localization
30	Metals/Ions
16	Molecular Weight [Da]
23	Natural Substrates/ Products (Substrates)
87	Organism
6	Pathway
8	pH Optimum
2	pH Range
3	pI Value
3	Posttranslational Modification
45	Protein Variants
13	Purification (Commentary)
1	Reaction
17	Reaction Type
77	Reference
71	Source Tissue
27	Specific Activity [micromol/min/mg]
6	Storage Stability
237	Substrates and Products (Substrate)
15	Subunits
176	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]
3	Temperature Range [°C]
3	Temperature Stability [°C]
15	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 2.4.1.65 - 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

GDP-beta-L-fucose + asialofetuin

GDP + ?

Homo sapiens

-

-

736817

-

-

?

GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-D-glucosaminyl-R

GDP + beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl-R

2 entries

GDP-beta-L-fucose + NeuAcalpha2-3Galbeta1-4Glc-NAcbeta1-3Galbeta1-4GlcNAcbeta1-3Galbeta1-4Glcbeta1-ceramide

?

Homo sapiens

-

the enzyme catalyzes the fucose transfer from GDP-fucose to GlcNAc residues of the sialylated polylactosamine acceptor leading to two isomeric monofucosyl antigens, VIM2 and sialyl-Lex

693000

-

-

?

GDP-fucose + Gal-beta-1,4GlcNAc-beta-1-R

GDP + Gal-beta-1,4(fuc-alpha-1,3)GlcNAc-beta-1-R

Homo sapiens

-

-

661341

-

-

?

GDP-L-fucose + 1,3-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R

GDP + 1,3-beta-D-galactosyl-(alpha-(1,4)-L-fucosyl)-N-acetyl-D-glucosaminyl-R

11 entries

GDP-L-fucose + Lewis antigen

GDP + fucosylated Lewis antigen

Homo sapiens

-

on the cell surface of hepatocarcinoma cells H7721

662544

-

-

?

additional information

?

-

4 entries

GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-D-glucosaminyl-R

GDP + beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl-R

Homo sapiens

-

isoform Fut3 predominantly exhibits alpha1-4 fucosyltransferase activity

736582

-

-

?

GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-D-glucosaminyl-R

GDP + beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl-R

Mus musculus

-

-

736194

-

-

?

GDP-L-fucose + 1,3-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R

GDP + 1,3-beta-D-galactosyl-(alpha-(1,4)-L-fucosyl)-N-acetyl-D-glucosaminyl-R

Helicobacter pylori

O32631

inactivation of the enzyme eliminates expression of all Lewis antigens

637638

-

-

?

GDP-L-fucose + 1,3-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R

GDP + 1,3-beta-D-galactosyl-(alpha-(1,4)-L-fucosyl)-N-acetyl-D-glucosaminyl-R

Helicobacter pylori UA948

O32631

inactivation of the enzyme eliminates expression of all Lewis antigens

637638

-

-

?

GDP-L-fucose + 1,3-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R

GDP + 1,3-beta-D-galactosyl-(alpha-(1,4)-L-fucosyl)-N-acetyl-D-glucosaminyl-R

Homo sapiens

-

the enzyme catalyzes the synthesis of fucosylated Lewis motifs that are associated with cell-adhesion events and are differentially expressed during cell differentiation

637637

-

-

?

GDP-L-fucose + 1,3-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R

GDP + 1,3-beta-D-galactosyl-(alpha-(1,4)-L-fucosyl)-N-acetyl-D-glucosaminyl-R

Homo sapiens

P21217

the enzyme may catalyze alpha1-3 and alpha-1,4 glycosidic linkages involved in the expression of VIM-2, Lewis A, Lewis B, sialyl Lewis X and Lewis X/SSEA-1 antigens. May be involved in blood group Lewis determination. Lewis-positive individuals have an active enzyme while Lewis-negative individuals have an inactive enzyme

637651, 637652, 637653, 637654

-

-

?

GDP-L-fucose + 1,3-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R

GDP + 1,3-beta-D-galactosyl-(alpha-(1,4)-L-fucosyl)-N-acetyl-D-glucosaminyl-R

Homo sapiens

-

the enzyme may catalyze alpha1-3 and alpha-1,4 glycosidic linkages involved in the expression of VIM-2, Lewis A, Lewis B, sialyl Lewis X and Lewis X/SSEA-1 antigens. May be involved in blood group Lewis determination. Lewis-positive individuals have an active enzyme while Lewis-negative individuals have an inactive enzyme

637654

-

-

?

GDP-L-fucose + 1,3-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R

GDP + 1,3-beta-D-galactosyl-(alpha-(1,4)-L-fucosyl)-N-acetyl-D-glucosaminyl-R

Homo sapiens

P21217

the enzyme may catalyze alpha1-3 and alpha-1,4 glycosidic linkages involved in the expression of VIM-2, Lewis A, Lewis B, sialyl Lewis X and Lewis X/SSEA-1 antigens. May be involved in blood group Lewis determination. Lewis-positive individuals have an active enzyme while Lewis-negative individuals have an inactive enzyme

637655, 637656, 637657

-

-

?

GDP-L-fucose + 1,3-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R

GDP + 1,3-beta-D-galactosyl-(alpha-(1,4)-L-fucosyl)-N-acetyl-D-glucosaminyl-R

Homo sapiens

-

the enzyme may catalyze alpha1-3 and alpha-1,4 glycosidic linkages involved in the expression of VIM-2, Lewis A, Lewis B, sialyl Lewis X and Lewis X/SSEA-1 antigens. May be involved in blood group Lewis determination. Lewis-positive individuals have an active enzyme while Lewis-negative individuals have an inactive enzyme

637657

-

-

?

GDP-L-fucose + 1,3-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R

GDP + 1,3-beta-D-galactosyl-(alpha-(1,4)-L-fucosyl)-N-acetyl-D-glucosaminyl-R

Homo sapiens

P21217

the enzyme may catalyze alpha1-3 and alpha-1,4 glycosidic linkages involved in the expression of VIM-2, Lewis A, Lewis B, sialyl Lewis X and Lewis X/SSEA-1 antigens. May be involved in blood group Lewis determination. Lewis-positive individuals have an active enzyme while Lewis-negative individuals have an inactive enzyme

637658, 637659

-

-

?

GDP-L-fucose + 1,3-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R

GDP + 1,3-beta-D-galactosyl-(alpha-(1,4)-L-fucosyl)-N-acetyl-D-glucosaminyl-R

Homo sapiens

-

the enzyme may catalyze alpha1-3 and alpha-1,4 glycosidic linkages involved in the expression of VIM-2, Lewis A, Lewis B, sialyl Lewis X and Lewis X/SSEA-1 antigens. May be involved in blood group Lewis determination. Lewis-positive individuals have an active enzyme while Lewis-negative individuals have an inactive enzyme

637659

-

-

?

GDP-L-fucose + 1,3-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R

GDP + 1,3-beta-D-galactosyl-(alpha-(1,4)-L-fucosyl)-N-acetyl-D-glucosaminyl-R

Homo sapiens

P21217

the enzyme may catalyze alpha1-3 and alpha-1,4 glycosidic linkages involved in the expression of VIM-2, Lewis A, Lewis B, sialyl Lewis X and Lewis X/SSEA-1 antigens. May be involved in blood group Lewis determination. Lewis-positive individuals have an active enzyme while Lewis-negative individuals have an inactive enzyme

637660

-

-

?

GDP-L-fucose + 1,3-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R

GDP + 1,3-beta-D-galactosyl-(alpha-(1,4)-L-fucosyl)-N-acetyl-D-glucosaminyl-R

Pan troglodytes

O19058

the enzyme may catalyze alpha-1,3 and alpha-1,4 glycosidic linkages involved in expression of sialyl Lewis X and Lewis X/SSEA-1 antigens. It may be involved in blood group Lewis determination

637649

-

-

?

additional information

?

-

Homo sapiens

P51993

the enzyme is involved in the biosynthesis of the E-selectin ligand, sialyl-Lewis X. Catalyzes the transfer of fucose from GDP-beta-fucose to alpha-2,3 sialylated substrates

639545

-

-

?

additional information

?

-

Homo sapiens

-

the enzyme is involved in the biosynthesis of the E-selectin ligand, sialyl-Lewis X. Catalyzes the transfer of fucose from GDP-beta-fucose to alpha-2,3 sialylated substrates

639545

-

-

?

additional information

?

-

Homo sapiens

-

the enzyme is involved in the biosynthesis of the sialyl Lewis x, i.e. Lex, epitope on leukocytes, which has been identified as an important component of leukocyte ligands for E- and P-selectin

662567

-

-

?

additional information

?

-

Homo sapiens

-

the strong correlation between the promoter activity of the FUT III gene and the high expression of sialyl Le(a) observed in different colon carcinoma cell lines seems to conform the important regulatory role of FUT3 in the synthesis of sialyl Le(a)

678373

-

-

?