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2.4.1.66: procollagen glucosyltransferase

This is an abbreviated version!
For detailed information about procollagen glucosyltransferase, go to the full flat file.

Word Map on EC 2.4.1.66

Reaction

UDP-alpha-D-glucose
+
[procollagen]-(5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysine
=
UDP
+
[procollagen]-(5R)-5-O-[alpha-D-glucosyl-(1->2)-beta-D-galactosyl]-5-hydroxy-L-lysine

Synonyms

collagen glucosyltransferase, collagen hydroxylysyl glucosyltransferase, galactosylhydroxylysine glucosyltransferase, galactosylhydroxylysyl glucosyltransferase, GGT, glucosyltransferase, uridine diphosphoglucose-collagen, LH3, LH3/PLOD3, lysyl hydroxylase, lysyl hydroxylase 3, More, multifunctional procollagen lysine hydroxylase and glycosyltransferase, PLOD3, UDP-glucose-collagen glucosyltransferase, UDP-glucose:galactosylhydroxylysine-collagen glucosyltransferase, uridine diphosphoglucose-collagen glucosyltransferase

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.1 Hexosyltransferases
                2.4.1.66 procollagen glucosyltransferase

Inhibitors

Inhibitors on EC 2.4.1.66 - procollagen glucosyltransferase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Acetylsalicylic acid
-
aspirin
Ca2+
-
5-10 mM: 10-15% inhibition of Mn2+-activated enzyme
cAMP
-
4.5 mM: 26% inhibition
Carminic acid
-
non-competitive, mechanism
Cd2+
-
inhibits Mn2+-activated enzyme
Co2+
-
inhibits at high concentrations, inhibits Mn2+-activated enzyme
Cu2+
-
inhibits Mn2+-activated enzyme
D-glucosamine
-
-
Fe2+
-
inhibits at high concentrations
Fe3+
-
inhibits Mn2+-activated enzyme, 0.03 mM: 27% inhibition of activity with 0.01 mM Mn2+ and 0.035 mM UDP-glucose
Mn2+
-
soluble enzyme, above 50 mM
Mn2+-UDP-complex
-
competitive inhibition to UDP-glucose, non-competitive to collagen
-
Ni2+
-
inhibits Mn2+-activated enzyme
p-chloromercuribenzoate
-
membrane-bound enzyme, 6 and 10 mM: 54% inhibition
p-hydroxymercuribenzoate
-
1 mM: complete inhibition
p-mercuribenzoate
-
0.0007 mM: 50% inhibition, substrates plus Mn2+ or Mn2+ alone partially protect
sucrose
-
membrane-bound enzyme, 0.42 M: 88% inhibition, also inhibits soluble enzyme
UTP
-
membrane-bound enzyme, 6 mM: complete inhibition
Zn2+
-
kinetics
additional information
-