2.4.1.66: procollagen glucosyltransferase

This is an abbreviated version!
For detailed information about procollagen glucosyltransferase, go to the full flat file.

Reaction

Synonyms

collagen glucosyltransferase, collagen hydroxylysyl glucosyltransferase, galactosylhydroxylysine glucosyltransferase, galactosylhydroxylysyl glucosyltransferase, GGT, glucosyltransferase, uridine diphosphoglucose-collagen, LH3, LH3/PLOD3, lysyl hydroxylase, lysyl hydroxylase 3, More, multifunctional procollagen lysine hydroxylase and glycosyltransferase, PLOD3, UDP-glucose-collagen glucosyltransferase, UDP-glucose:galactosylhydroxylysine-collagen glucosyltransferase, uridine diphosphoglucose-collagen glucosyltransferase

ECTree

     2 Transferases

         2.4 Glycosyltransferases

             2.4.1 Hexosyltransferases

                2.4.1.66 procollagen glucosyltransferase

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Results	in table
5	Activating Compound
7	AA Sequence
1	CAS Registry Number
13	Cloned(Commentary)
2	Crystallization (Commentary)
131	Disease/ Diagnostics
4	Expression
11	General Information
12	General Stability
30	Inhibitors
2	Ki Value [mM]
30	KM Value [mM]
35	Localization
96	Metals/Ions
13	Molecular Weight [Da]
27	Natural Substrates/ Products (Substrates)
44	Organism
2	Pathway
7	PDB ID
12	pH Optimum
2	pH Range
1	pI Value
4	Posttranslational Modification
48	Protein Variants
45	Purification (Commentary)
6	Reaction
1	Reaction Type
44	Reference
97	Source Tissue
17	Specific Activity [micromol/min/mg]
10	Storage Stability
143	Substrates and Products (Substrate)
8	Subunits
42	Synonyms
1	Systematic Name
14	Temperature Optimum [°C]
2	Temperature Stability [°C]
1	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 2.4.1.66 - procollagen glucosyltransferase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

UDP-alpha-D-glucose + [procollagen]-(5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysine

UDP + [procollagen]-(5R)-5-O-[alpha-D-glucosyl-(1->2)-beta-D-galactosyl]-5-hydroxy-L-lysine

Homo sapiens

O60568

-

757776

-

-

?

UDP-glucose + (2S,5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysine-[procollagen]

UDP + (2S,5R)-5-O-[alpha-D-glucosyl-(1->2)-beta-D-galactosyl]-5-hydroxy-L-lysine-[procollagen]

Homo sapiens

-

-

737090, 737134

-

-

?

UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen

UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen

14 entries

UDP-glucose + type VII collagen

?

Homo sapiens

-

-

737090

-

-

?

additional information

?

-

2 entries

UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen

UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen

Bos taurus

-

involved in collagen biosynthesis

439149

-

-

?

UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen

UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen

Bos taurus

-

glycosylation in the course of procollagen and collagen biosynthesis, carbohydrate attachment is an essential step in the protocollagen biosynthesis, postribosomal modification

636779

-

-

?

UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen

UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen

Caenorhabditis elegans

-

posttranslational modification of collagen

439167, 636791

-

-

?

UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen

UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen

Cavia porcellus

-

probably postribosomal, attachment of galactose and glucose to hydroxylysine in collagen could conceivably function as part of the control mechanism signaling completion of the molecule and initiating its release

636772

-

-

?

UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen

UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen

Cavia porcellus

-

involved in collagen biosynthesis

439149

-

-

?

UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen

UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen

Gallus gallus

-

involved in collagen biosynthesis

439149, 636780

-

-

?

UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen

UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen

Gallus gallus

-

intracellular enzyme of collagen biosynthesis

636781

-

-

?

UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen

UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen

Homo sapiens

-

involved in collagen biosynthesis

439149

-

-

?

UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen

UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen

Homo sapiens

-

may play a major role in the mechanism of platelet:collagen adhesion

636785

-

-

?

UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen

UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen

Homo sapiens

-

posttranslational modification of collagen

439149, 439167, 489282, 636791

-

-

?

UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen

UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen

Homo sapiens

-

together with EC 2.4.1.50 involved in biosynthesis of glucosylgalactosylhydroxylysine units in collagens, basement membranes and certain serum glycoproteins

439149, 489282

-

-

?

UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen

UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen

Rattus norvegicus

-

involved in collagen biosynthesis

439149

-

-

?

UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen

UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen

Rattus norvegicus

-

posttranslational modification of collagen

439149, 636789

-

-

?

UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen

UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen

Rattus norvegicus

-

marker enzyme of collagen biosynthesis

636789

-

-

?

additional information

?

-

Homo sapiens

-

there must be an additional glucosyltransferase to LH3 that is responsible for most of the collagen glucosylation in vivo

439166

-

-

?

additional information

?

-

Mus musculus

-

the reduction of the galactosylhydroxylysyl glucosyltransferase activity of LH3 disrupts the localization of type IV collagen, and thus the formation of basement membranes during mouse embryogenesis leading to lethality at embryonic day 9.5-14.5. Survival of hypomorphic embryos and the formation of the basement membrane are directly correlated with the level of galactosylhydroxylysyl glucosyltransferase activity. An LH3-knockout mouse lacks galactosylhydroxylysyl glucosyltransferase. Lysyl hydroxylase 3 is the main molecule responsible for galactosylhydroxylysyl glucosyltransferase activity. Galactosylhydroxylysyl glucosyltransferase is essential for the formation of the basement membrane

675017

-

-

?