2.4.1.79: globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase

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For detailed information about globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase, go to the full flat file.

Reaction

Synonyms

acetylgalactosaminyltransferase, uridine diphosphoacetylgalactosamine-galactosylgalactosylglucosylceramide, acetylgalactosaminyltransferase, uridine diphosphoacetylgalactosamine-glycosphingolipid, beta(1->3) N-acetylgalactosaminyltransferase, beta1,3GalNAc-T, EC 2.4.1.154, galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase, GalNAc transferase, globoside N-acetylgalactosaminyltransferase, globoside synthetase, glycosphingolipid beta-N-acetylgalactosaminyltransferase, UDP-N-acetylgalactosamine:globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase, UDP-N-acetylgalactosamine:globotriaosylceramide beta-3-N-acetylgalactosaminyltransferase

ECTree

     2 Transferases

         2.4 Glycosyltransferases

             2.4.1 Hexosyltransferases

                2.4.1.79 globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase

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Results	in table
10	Activating Compound
6	AA Sequence
3	Application
2	CAS Registry Number
1	Cloned(Commentary)
2	General Stability
14	Inhibitors
8	KM Value [mM]
5	Localization
11	Metals/Ions
3	Molecular Weight [Da]
3	Natural Substrates/ Products (Substrates)
16	Organism
4	Pathway
5	pH Optimum
1	pH Range
1	Posttranslational Modification
1	Protein Variants
3	Purification (Commentary)
1	Reaction
1	Reaction Type
11	Reference
20	Source Tissue
1	Specific Activity [micromol/min/mg]
1	Storage Stability
27	Substrates and Products (Substrate)
2	Subunits
12	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]

Natural Substrates Products

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Natural Substrates Products on EC 2.4.1.79 - globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

UDP-N-acetyl-D-galactosamine + D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide

UDP + N-acetyl-D-galactosaminyl-1,3-D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide

2 entries

UDP-N-acetyl-D-galactosamine + globotriosylceramide

UDP + globotetraosylceramide

Mesocricetus auratus

-

glycosphingolipid metabolism

488622

-

-

?

UDP-N-acetyl-D-galactosamine + D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide

UDP + N-acetyl-D-galactosaminyl-1,3-D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide

Cavia porcellus

-

enzyme is involved in globoside biosynthesis

489381

-

-

?

UDP-N-acetyl-D-galactosamine + D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide

UDP + N-acetyl-D-galactosaminyl-1,3-D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide

Homo sapiens

O75752

the enzyme is responsible for synthesis of P blood group antigen. Mutations capable of abolishing enzyme function are present in individuals with the Pk phenotype

489385

-

-

?