2.4.1.79: globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase

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For detailed information about globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase, go to the full flat file.

Reaction

Synonyms

acetylgalactosaminyltransferase, uridine diphosphoacetylgalactosamine-galactosylgalactosylglucosylceramide, acetylgalactosaminyltransferase, uridine diphosphoacetylgalactosamine-glycosphingolipid, beta(1->3) N-acetylgalactosaminyltransferase, beta1,3GalNAc-T, EC 2.4.1.154, galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase, GalNAc transferase, globoside N-acetylgalactosaminyltransferase, globoside synthetase, glycosphingolipid beta-N-acetylgalactosaminyltransferase, UDP-N-acetylgalactosamine:globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase, UDP-N-acetylgalactosamine:globotriaosylceramide beta-3-N-acetylgalactosaminyltransferase

ECTree

     2 Transferases

         2.4 Glycosyltransferases

             2.4.1 Hexosyltransferases

                2.4.1.79 globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase

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Results	in table
10	Activating Compound
6	AA Sequence
3	Application
2	CAS Registry Number
1	Cloned(Commentary)
2	General Stability
14	Inhibitors
8	KM Value [mM]
5	Localization
11	Metals/Ions
3	Molecular Weight [Da]
3	Natural Substrates/ Products (Substrates)
16	Organism
4	Pathway
5	pH Optimum
1	pH Range
1	Posttranslational Modification
1	Protein Variants
3	Purification (Commentary)
1	Reaction
1	Reaction Type
11	Reference
20	Source Tissue
1	Specific Activity [micromol/min/mg]
1	Storage Stability
27	Substrates and Products (Substrate)
2	Subunits
12	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]

Systematic Name

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Systematic Name on EC 2.4.1.79 - globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase

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SYSTEMATIC NAME

IUBMB Comments

UDP-N-acetyl-D-galactosamine:alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide III3-beta-N-acetyl-D-galactosaminyltransferase

Globoside is a neutral glycosphingolipid in human erythrocytes and has blood-group-P-antigen activity [4]. The enzyme requires a divalent cation for activity, with Mn2+ required for maximal activity [3]. UDP-GalNAc is the only sugar donor that is used efficiently by the enzyme: UDP-Gal and UDP-GlcNAc result in very low enzyme activity [3]. Lactosylceramide, globoside and gangliosides GM3 and GD3 are not substrates [4]. For explanation of the superscripted '3' in the systematic name, see {iupac/misc/glylp#5.3::GL-5.3.4}.