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2.4.1.80: ceramide glucosyltransferase

This is an abbreviated version!
For detailed information about ceramide glucosyltransferase, go to the full flat file.

Word Map on EC 2.4.1.80

Reaction

UDP-alpha-D-glucose
+
an N-acylsphingosine
=
UDP
 +
a beta-D-glucosyl-N-acylsphingosine

Synonyms

ceramide glucosyltransferase, ceramide glycosyltransferase, ceramide:UDP-glucose glucosyltransferase, ceramide:UDPGlc glucosyltransferase, cerebroside synthase, CGT, cgt-1, cgt-2, cgt-3, GCS, GCS1, GlcCer synthase, GlcCerS, GlcT, GlcT-1, glucosylceramide synthase, glucosyltransferase, uridine diphosphoglucose-ceramide, GluT, UDP glucose-ceramide glucosyltransferase, UDP-Glc:ceramide glucosyltransferase, UDP-glucoase:ceramide glucosyltransferase, UDP-glucose ceramide glucosyltransferase, UDP-glucose ceramide glycosyltransferase, UDP-glucose: ceramide glucosyltransferase, UDP-glucose:ceramide glucosyltransferase, Ugcg, uridine diphosphate (UDP)-glucose:N-acylsphingosine D-glucosyltransferase, uridine diphosphoglucose-ceramide glucosyltransferase

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.1 Hexosyltransferases
                2.4.1.80 ceramide glucosyltransferase

Source Tissue

Source Tissue on EC 2.4.1.80 - ceramide glucosyltransferase

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
high enzyme expression level and content
Manually annotated by BRENDA team
-
of leukaemic patients before chemotherapy
Manually annotated by BRENDA team
-
GCS expression is significantly decreased in cortex of Alzheimer disease patients
Manually annotated by BRENDA team
-
strain K1, and GM3-mutant strain Z65
Manually annotated by BRENDA team
-
ovary cells expressing the LT antigen
Manually annotated by BRENDA team
high enzyme expression level and content
Manually annotated by BRENDA team
-
80% of the activity in outer epidermis, 20% in lower epidermis
Manually annotated by BRENDA team
-
cerebellar granule cells are treated with GCS inhibitor D-threo-2-palmitoylamino-3-pyrrolidino-1-propanol which induces an increase in log-chain ceramides, loss of viability and dramatic changes in neuron/neurite morphology
Manually annotated by BRENDA team
-
highest activity
Manually annotated by BRENDA team
-
it is shown that overexpression of the GCS gene is associated with multidrug resistance of leukemia cells
Manually annotated by BRENDA team
vinorelbine-resistant, high expression of enzyme GCS in lung cancer cells resistant to vinorelbine-induced apoptosis
Manually annotated by BRENDA team
-
peripheral blood cell of leukaemic patients before chemotherapy
Manually annotated by BRENDA team
additional information