2.4.1.83: dolichyl-phosphate beta-D-mannosyltransferase

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For detailed information about dolichyl-phosphate beta-D-mannosyltransferase, go to the full flat file.

Word Map on EC 2.4.1.83

2.4.1.83

n-linked

n-glycosylation

glycosylphosphatidylinositol

lipid-linked

reesei

dolichol-phosphate-mannose

asparagine-linked

amphomycin

dolichol-linked

glc3man9glcnac2-pp-dol

mannoproteins

c-mannosylation

medicine

drug development

Reaction

Synonyms

AglD, bDPM1, D-P-M, Dol-P Man synthase, Dol-P-Man synthase, Dol-P-Man synthase1, Dol-P-Man-synthase, Dol-P-Mansynthase, Dol-PMan synthase, dolichol phosphate mannose synthase, dolichol phosphoryl mannose synthase, dolichol-P-mannose synthase, dolicholphosphate mannose synthase, dolichyl mannosyl phosphate synthase, dolichyl phosphate mannosyltransferase, dolichyl-phosphate mannose synthase, dolichyl-phosphate mannosyltransferase, dolichyl-phospho-mannose synthase, dolichylphosphate mannose synthase, DPM, DPM synthase, DPM1, DPMS, DPMS1, GDP-Man:DolP mannosyltransferase, GDP-mannose-dolichol phosphate mannosyltransferase, GDPMan:DolP mannosyltransferase, GDPmannose-dolichylmonophosphate mannosyltransferase, GDPmannose:dolichyl-phosphate mannosyltransferase, mannosylphospho dolichol synthase, mannosylphosphodolichol synthase, mannosylphosphoryldolichol synthase, mannosyltransferase, guanosine diphosphomannose-dolichol phosphate, MPD synthase, PF0058, Pfdpm1, PfDPMS, PH0051

ECTree

2 Transferases

2.4 Glycosyltransferases

2.4.1 Hexosyltransferases

2.4.1.83 dolichyl-phosphate beta-D-mannosyltransferase

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Results	in table
17	Activating Compound
5205	AA Sequence
4	Application
1	CAS Registry Number
16	Cloned(Commentary)
2	Crystallization (Commentary)
22	Disease/ Diagnostics
3	Expression
28	General Information
4	General Stability
53	Inhibitors
7	Ki Value [mM]
39	KM Value [mM]
33	Localization
23	Metals/Ions
6	Molecular Weight [Da]
12	Natural Substrates/ Products (Substrates)
67	Organism
9	Pathway
12	pH Optimum
2	pH Range
5	Posttranslational Modification
18	Protein Variants
16	Purification (Commentary)
6	Reaction
1	Reaction Type
62	Reference
27	Source Tissue
7	Specific Activity [micromol/min/mg]
8	Storage Stability
78	Substrates and Products (Substrate)
9	Subunits
77	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
1	Temperature Range [°C]
3	Temperature Stability [°C]
9	Turnover Number [1/s]

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Application on EC 2.4.1.83 - dolichyl-phosphate beta-D-mannosyltransferase

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drug development

Trypanosoma brucei

inhibition of DPMS is a promising strategy for the development of anti-trypanosomal agents. Thiazolidinones [(5Z)-5-[[4-(benzyloxy)phenyl]methylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid, [(5Z)-5-[[3,4-bis(benzyloxy)phenyl]methylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid and [(5Z)-5-[(2-hydroxyphenyl)methylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid in particular are promising candidates for further development because of their respective activities against trypanosomal DPMS and GPI anchor biosynthesis

702559

medicine

3 entries