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2.4.1.83: dolichyl-phosphate beta-D-mannosyltransferase

This is an abbreviated version!
For detailed information about dolichyl-phosphate beta-D-mannosyltransferase, go to the full flat file.

Word Map on EC 2.4.1.83

Reaction

GDP-alpha-D-mannose
+
dolichyl phosphate
=
GDP
 +
dolichyl beta-D-mannosyl phosphate

Synonyms

AglD, bDPM1, D-P-M, Dol-P Man synthase, Dol-P-Man synthase, Dol-P-Man synthase1, Dol-P-Man-synthase, Dol-P-Mansynthase, Dol-PMan synthase, dolichol phosphate mannose synthase, dolichol phosphoryl mannose synthase, dolichol-P-mannose synthase, dolicholphosphate mannose synthase, dolichyl mannosyl phosphate synthase, dolichyl phosphate mannosyltransferase, dolichyl-phosphate mannose synthase, dolichyl-phosphate mannosyltransferase, dolichyl-phospho-mannose synthase, dolichylphosphate mannose synthase, DPM, DPM synthase, DPM1, DPMS, DPMS1, GDP-Man:DolP mannosyltransferase, GDP-mannose-dolichol phosphate mannosyltransferase, GDPMan:DolP mannosyltransferase, GDPmannose-dolichylmonophosphate mannosyltransferase, GDPmannose:dolichyl-phosphate mannosyltransferase, mannosylphospho dolichol synthase, mannosylphosphodolichol synthase, mannosylphosphoryldolichol synthase, mannosyltransferase, guanosine diphosphomannose-dolichol phosphate, MPD synthase, PF0058, Pfdpm1, PfDPMS, PH0051

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.1 Hexosyltransferases
                2.4.1.83 dolichyl-phosphate beta-D-mannosyltransferase

Inhibitors

Inhibitors on EC 2.4.1.83 - dolichyl-phosphate beta-D-mannosyltransferase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
5,5'-dithiobis(2-nitrobenzoic acid)
-
-
Amphomycin
GDP-2-deoxy-D-glucose
-
-
GDP-3-deoxy-D-mannose
-
-
GDP-4-deoxy-D-mannose
-
-
GDP-6-deoxy-D-mannose
-
-
GDP-D-glucose
-
0.01 mM, 50% inhibition
lucifer yellow iodoacetamide
-
-
Nonidet P-40
-
0.01%, 50% inhibition
p-hydroxymercuribenzoate
phosphatidylinositol
-
relative activity: 70%
tunicamycin
-
-
[(5Z)-4-oxo-5-(phenylmethylidene)-2-thioxo-1,3-thiazolidin-3-yl]acetic acid
-
42% residual DPMS activity in the presence of 1 mM
[(5Z)-5-[(2-hydroxyphenyl)methylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid
-
23% residual DPMS activity in the presence of 1 mM. Does not affect dolichyl D-mannosyl phosphate production in the cell-free system, but potently inhibits formation of mannosylated glycosylphosphatidylinositol intermediates
[(5Z)-5-[(3-hydroxyphenyl)methylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid
-
90% residual DPMS activity in the presence of 1 mM
[(5Z)-5-[(4-chlorophenyl)methylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid
-
86% residual DPMS activity in the presence of 1 mM
[(5Z)-5-[(4-cyanophenyl)methylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid
-
73% residual DPMS activity in the presence of 1 mM
[(5Z)-5-[(4-ethynylphenyl)methylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid
-
94% residual DPMS activity in the presence of 1 mM
[(5Z)-5-[(4-hydroxyphenyl)methylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid
-
70% residual DPMS activity in the presence of 1 mM. Abolishes the formation of dolichyl D-mannosyl phosphate almost completely, and significantly reduces the formation of downstream glycosylphosphatidylinositol intermediates
[(5Z)-5-[[3,4-bis(benzyloxy)phenyl]methylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid
-
20% residual DPMS activity in the presence of 1 mM. Abolishes the formation of dolichyl D-mannosyl phosphate almost completely, and significantly reduces the formation of downstream glycosylphosphatidylinositol intermediates
[(5Z)-5-[[3-(benzyloxy)phenyl]methylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid
-
23% residual DPMS activity in the presence of 1 mM
[(5Z)-5-[[4-(benzyloxy)phenyl]methylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid
-
10% residual DPMS activity in the presence of 1 mM. Does not affect dolichyl D-mannosyl phosphate production in the cell-free system, but potently inhibits formation of mannosylated glycosylphosphatidylinositol intermediates
additional information
-