2.4.1.87: N-acetyllactosaminide 3-alpha-galactosyltransferase

This is an abbreviated version!
For detailed information about N-acetyllactosaminide 3-alpha-galactosyltransferase, go to the full flat file.

Reaction

Synonyms

alpha(1,3)GT, alpha-1,3-galactosyltransferase, alpha-1,3galactosyltransferase, alpha-D-galactosyltransferase, alpha-galactosyltransferase, alpha1,3-galactosyltransferase, alpha1,3-GalT, alpha1,3galactosyltransferase, alpha1,3GalT, alpha1,3GT, alpha3-galactosyltransferase, alpha3Gal-T, alpha3GalT, alpha3GT, beta-D-galactosyl-N-acetylglucosaminylglycopeptide alpha-1,3-galactosyltransferase, blood group glycosyltransferase, EC 2.4.1.124, EC 2.4.1.151, galactosyltransferase, uridine diphosphogalactose-acetyllactosamine, galactosyltransferase, uridine diphosphogalactose-acetyllactosamine alpha1-->3-, galactosyltransferase, uridine diphosphogalactose-galactosylacetylglucosamine alpha-1,3-, galactosyltransferase, uridine diphosphogalactose-galactosylacetylglucosaminylgalactosylglucosylceramide, GALT, GGTA1, glucosaminylglycopeptide alpha-1,3-galactosyltransferase, GTB, iGb3 synthase, iGb3S, N-acetyllactoseaminide 3-alpha-D-galactosyltransferase, one, three-galactosyltransferase, Otg1p, Otg2p, Otg3p, UDP-D-Gal(1,4)-D-GlcNAc alpha(1,3)-galactosyltransferase, UDP-Gal:N-acetyllactoseaminide alpha(1,3)-galactosyltransferase, UDP-galactose beta galactosyl alpha1,3-galactosyltransferase, UDP-galactose beta-galactosyl alpha-1,3-galactosyltransferase, UDP-galactose-acetyllactosamine alpha-D-galactosyltransferase, UDP-galactose-acetyllactoseamine alpha-D-galactosyltransferase, UDP-galactose:beta-D-galactosyl-beta-1,4-N-acetyl-D-glucosaminyl-glycopeptide alpha-1,3-D-galactosyltransferase, UDP-galactose:N-acetyllactoseaminide 3-alpha-D-galactosyltransferase, UDP-GalN-acetyllactoseaminide alpha-1,3-D-UDP-GalGalbeta1-->4GlcNAC-R alpha1-->3-galactosyltransferase, UDPgalactose:beta-D-galactosyl-beta-1,4-N-acetyl-D-glucosaminyl-glycopeptide alpha-1,3-D-galactosyltransferase, uridine diphosphogalactose-acetyllactosamine alpha1-->3-galactosyltransferase, uridine diphosphogalactose-galactosylacetylglucosaminylgalactosylglucosylceramide galactosyltransferase, WciN, wclR

ECTree

     2 Transferases

         2.4 Glycosyltransferases

             2.4.1 Hexosyltransferases

                2.4.1.87 N-acetyllactosaminide 3-alpha-galactosyltransferase

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Results	in table
4	Activating Compound
46	AA Sequence
12	Application
4	CAS Registry Number
29	Cloned(Commentary)
1	Cofactor
9	Crystallization (Commentary)
95	Disease/ Diagnostics
30	General Information
2	General Stability
9	Inhibitors
14	kcat/KM [mM/s]
2	Ki Value [mM]
69	KM Value [mM]
7	Localization
27	Metals/Ions
10	Molecular Weight [Da]
25	Natural Substrates/ Products (Substrates)
72	Organism
4	Pathway
28	PDB ID
10	pH Optimum
2	pH Range
54	Protein Variants
11	Purification (Commentary)
4	Reaction
1	Reaction Type
67	Reference
26	Source Tissue
13	Specific Activity [micromol/min/mg]
2	Storage Stability
106	Substrates and Products (Substrate)
7	Subunits
136	Synonyms
1	Systematic Name
7	Temperature Optimum [°C]
27	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 2.4.1.87 - N-acetyllactosaminide 3-alpha-galactosyltransferase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

UDP-alpha-D-galactose + beta-D-galactosyl-(1->4)-beta-N-acetyl-D-glucosaminyl-R

UDP + alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-N-acetylglucosaminyl-R

8 entries

UDP-alpha-D-galactose + N-acetyllactosamine

UDP + ?

2 entries

UDP-galactose + alpha-L-Fucp-1,2-beta-D-Galp-O(CH2)7CH3

UDP + ?

Homo sapiens

-

The presence of UDP and Mn2+ has a marked influence on the thermodynamic parameters enthalpy and entropy of association, they decrease, binding to substrate is independent of UDP at physiological temperatures, but cooperatively is observed at lower temperatures

708606

-

-

?

UDP-galactose + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R

UDP + alpha-D-galactosyl-1,3-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R

3 entries

UDP-galactose + galactosyl-1,3-N-acetylglucosaminyl-1,3-galactosyl-1,4-glucosyl-1,1-ceramide

UDP + O-alpha-galactosyl-1,3-galactosyl-1,3-N-acetylglucosaminyl-1,3-galactosyl-1,4-glucosyl-1,1-ceramide

Oryctolagus cuniculus

-

biosynthesis of blood group B specific pentaglycosylceramide

489462

-

-

?

UDP-galactose + galactosyl-1,3-N-acetylglucosaminyl-1,3-galactosyl-1,4-glucosyl-1,1-ceramide

UDP + O-alpha-galactosyl-1,4-galactosyl-1,3-N-acetylglucosaminyl-1,3-galactosyl-1,4-glucosyl-1,1-ceramide

Oryctolagus cuniculus

-

biosynthesis of blood group B specific pentaglycosylceramide

489462

-

489462

?

UDP-galactose + lactose

UDP + ?

Bos taurus

P14769

wild-type enzyme, 37°C, MnCl2, 25 mM Tris-HCl, pH 7.0

707599

-

-

?

additional information

?

-

9 entries

UDP-alpha-D-galactose + beta-D-galactosyl-(1->4)-beta-N-acetyl-D-glucosaminyl-R

UDP + alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-N-acetylglucosaminyl-R

Ateles sp.

-

-

736656

-

-

?

UDP-alpha-D-galactose + beta-D-galactosyl-(1->4)-beta-N-acetyl-D-glucosaminyl-R

UDP + alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-N-acetylglucosaminyl-R

Callithrix jacchus

Q8SQ20

-

736656

-

-

?

UDP-alpha-D-galactose + beta-D-galactosyl-(1->4)-beta-N-acetyl-D-glucosaminyl-R

UDP + alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-N-acetylglucosaminyl-R

Eutheria

-

-

736656

-

-

?

UDP-alpha-D-galactose + beta-D-galactosyl-(1->4)-beta-N-acetyl-D-glucosaminyl-R

UDP + alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-N-acetylglucosaminyl-R

Lemuridae

-

-

736656

-

-

?

UDP-alpha-D-galactose + beta-D-galactosyl-(1->4)-beta-N-acetyl-D-glucosaminyl-R

UDP + alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-N-acetylglucosaminyl-R

Metatheria

-

-

736656

-

-

?

UDP-alpha-D-galactose + beta-D-galactosyl-(1->4)-beta-N-acetyl-D-glucosaminyl-R

UDP + alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-N-acetylglucosaminyl-R

Platyrrhini

-

-

736656

-

-

?

UDP-alpha-D-galactose + beta-D-galactosyl-(1->4)-beta-N-acetyl-D-glucosaminyl-R

UDP + alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-N-acetylglucosaminyl-R

Saimiri sp.

-

-

736656

-

-

?

UDP-alpha-D-galactose + beta-D-galactosyl-(1->4)-beta-N-acetyl-D-glucosaminyl-R

UDP + alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-N-acetylglucosaminyl-R

Sus scrofa

-

-

736808

-

-

?

UDP-alpha-D-galactose + N-acetyllactosamine

UDP + ?

Bos taurus

P14769

-

707367, 708604

-

-

?

UDP-alpha-D-galactose + N-acetyllactosamine

UDP + ?

Bos taurus

-

-

708604

-

-

?

UDP-galactose + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R

UDP + alpha-D-galactosyl-1,3-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R

Bos taurus

-

-

489472

-

489472

?

UDP-galactose + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R

UDP + alpha-D-galactosyl-1,3-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R

Mus musculus

P23336

gene expression is regulated developmentally

489469

-

489469

?

UDP-galactose + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R

UDP + alpha-D-galactosyl-1,3-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R

Rattus norvegicus

-

alpha(1,3)GT is able to synthesize Galalpha(1,3)Gal on glycoproteins destined for the cell surface. Igb3S shows no activity with glycoproteins but is capable of synthesizing Galalpha(1,3)Gal on glycolipids

658837

-

-

?

additional information

?

-

Bos taurus

-

-

489465

-

-

?

additional information

?

-

Bos taurus

-

functions in the biosynthesis of calf thymocyte cell-surface glycoconjugates including glycoproteins

489464

-

-

?

additional information

?

-

Bos taurus

-

functions in biosynthesis of calf thymocyte cell-surface glycoconjugates including glycoproteins

489464

-

-

?

additional information

?

-

Mus musculus

-

synthesis of Ehrlich ascites tumor cell glycoproteins

489463

-

-

?

additional information

?

-

Mus musculus

-

involved in the biosynthesis of alpha-D-galactosyl-terminated poly-N-acetyllactosamine glycans that occur on the surface of Ehrlich ascites tumor cells

489465

-

-

?

additional information

?

-

Mus musculus

-

iGb3S is an additional enzyme capable of synthesizing the xenoreactive Galalpha(1,3)Gal epitope. Galalpha(1,3)Gal synthesized by iGb3S, in contrast to alpha1,3GT, is resistant to downregulation by competition with alpha1,2fucosyltransferase. Galalpha(1,3)Gal synthesized by iGb3S is immunogenic and elicits antibodies in GGTA1-/- mice. Galalpha(1,3)Gal synthesized by iGb3S may affect survival of pig transplants in humans

675197

-

-

?

additional information

?

-

Rattus norvegicus

-

functions in the biosynthesis of cell surface polylactosaminoglycans on Novikoff cells, attachs a galactose to the N-acetylglucosaminyl residue introduced by EC 2.4.1.149

489473

-

-

?

additional information

?

-

Sus scrofa

AF415202

the alphaGal(1-3)Gal epitope is the major xenoantigen responsible for the hyperacute vascular rejection occurring in pig-to-primate organ transplantation

489479

-

-

?

additional information

?

-

Sus scrofa

-

the alphaGal(1-3)Gal epitope is the major xenoantigen responsible for the hyperacute vascular rejection occurring in pig-to-primate organ transplantation

489479

-

-

?