2.4.1.88: globoside alpha-N-acetylgalactosaminyltransferase
This is an abbreviated version!
For detailed information about globoside alpha-N-acetylgalactosaminyltransferase, go to the full flat file.
Word Map on EC 2.4.1.88
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2.4.1.88
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glycolipids
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fs
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glycosyltransferases
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histo-blood
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transfusion
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oligosaccharide
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glycosphingolipids
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n-acetylgalactosamine
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galnac
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gene-encoded
- 2.4.1.88
- glycolipids
- fs
- glycosyltransferases
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histo-blood
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transfusion
- oligosaccharide
- glycosphingolipids
- n-acetylgalactosamine
- galnac
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gene-encoded
Reaction
Synonyms
acetylgalactosaminyltransferase, uridine diphosphoacetylgalactosamine-globoside alpha-, cis-AB-transferase, Forss-S, Forssman synthase, Forssman synthetase, Forssmann glycolipid synthetase, FS, GBGT1, globoside acetylgalactosaminyltransferase, globoside alpha-1,3-N-acetylgalactosaminyltransferase 1, glycosyltransferase 6 (GT6) family member, GT6m5, GT6m6, GT6m7, histo-blood group ABO system transferase, More, uridine diphosphoacetylgalactosamine-globoside alpha-acetylgalactosaminyltransferase
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General Information
General Information on EC 2.4.1.88 - globoside alpha-N-acetylgalactosaminyltransferase
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malfunction
GBGT1 expression is epigenetically silenced through promoter hypermethylation in ovarian cancer
metabolism
the enzyme catalyzes the last step in the multi-step biosynthesis of the Forssman antigen, Fs antigen, a pentaglycosyl ceramide of the globo series glycosphingolipids. Involvement of DNA methylation in the synthesis of Fs antigen
physiological function
the deletion of exon 3 or 4, but not of exon 2 or 5, of human GTA transcripts bestows moderate Forssman glycolipid synthase activity. Strong Forssman glycolipid synthase activity is attained, in addition to GTA and GTB activities, by cointroducing one of those deletions and the replacement of the LeuGlyGly tripeptide sequence at codons 266 to 268 by GlyGlyAla substitution, i.e. to the residues of Forssman glycolipid synthase
additional information
the extent of DNA methylation inversely correlates with GBGT1 mRNA and protein expression
additional information
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the extent of DNA methylation inversely correlates with GBGT1 mRNA and protein expression