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2.4.2.1: purine-nucleoside phosphorylase

This is an abbreviated version!
For detailed information about purine-nucleoside phosphorylase, go to the full flat file.

Word Map on EC 2.4.2.1

Reaction

purine 2'-deoxyribonucleoside
+
phosphate
=
purine
 +
2-deoxy-alpha-D-ribose 1-phosphate

Synonyms

5'-deoxy-5'-methylthioadenosine phosphorylase II, 5'-methythioadenosine phosphorylase, adenine nucleoside phosphorylase, adenosine phosphorylase, AgPNP, AmPNP, ANP, ApMTAP, apPNP, bovPNP, bPNO, CKP1, cytokinin riboside phosphorylase, DeoD, deoD_1, DgPNP, EC592_06680, EcPNP, flB, GsPNPI, GsPNPII, GtPNP, hPNP, HpPNP, HsPNO, HsPNP, Ino-Guo phosphorylase, inosine phosphorylase, inosine-guanosine phosphorylase, KlacPNP, KLLA0_C16621g, MTAPII, MtbPNP, nucleotide phosphatase (2.4.2.1), PfPNP, phosphorylase, purine nucleoside, PiPNP, PNP, PNP 1, PNP 2, PNP I, PNP II, PNP-II, PNP-Zg, PNPase, pNPI, PNPII, Pu-NPase, punA, PUNP, PUNPI, PUNPII, purine deoxynucleoside phosphorylase, purine deoxyribonucleoside phosphorylase, purine nucleoside orthophosphate ribosyl transferase, purine nucleoside phosphorylase, purine nucleoside phosphorylase 1, purine nucleoside phosphorylase 2, purine nucleoside phosphorylase DeoD, purine nucleoside phosphorylase DeoD-type, purine nucleoside phosphorylase II, purine ribonucleoside phosphorylase, purine-nucleoside phosphorylases II, SalT, SSO2343, TgPNP, TTC0194, TTC1070, TtPNPI, TtPNPII, TvPNP, xanthosine phosphorylase, XAP, xapA, ylmD

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.2 Pentosyltransferases
                2.4.2.1 purine-nucleoside phosphorylase

Natural Substrates Products

Natural Substrates Products on EC 2.4.2.1 - purine-nucleoside phosphorylase

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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
1-methyladenosine + phosphate
1-methyladenine + alpha-D-ribose 1-phosphate
show the reaction diagram
-
-
-
r
1-methylguanosine + phosphate
1-methylguanine + alpha-D-ribose 1-phosphate
show the reaction diagram
-
-
-
r
2'-deoxyguanosine + phosphate
guanine + 2-deoxy-alpha-D-ribose 1-phosphate
show the reaction diagram
-
-
-
-
?
2-fluoro-2-deoxyadenosine + phosphate
?
show the reaction diagram
-
a toxic prodrug
-
-
?
5'-deoxy-5'-methylthioadenosine + phosphate
adenine + 5-deoxy-5-methylthio-alpha-D-ribose 1-phosphate
show the reaction diagram
5'-methylthioinosine + phosphate
hypoxanthine + 5-methylthio-alpha-D-ribose 1-phosphate
show the reaction diagram
-
-
-
r
6-mercaptopurine-2'-deoxyriboside + phosphate
6-mercaptopurine + 2-deoxy-alpha-D-ribose 1-phosphate
show the reaction diagram
-
-
-
r
7-methylguanine + alpha-D-ribose 1-phosphate
7-methylguanosine + phosphate
show the reaction diagram
-
-
-
r
7-methylguanosine + phosphate
7-methylguanine + alpha-D-ribose 1-phosphate
show the reaction diagram
8-azaguanine + alpha-D-ribose 1-phosphate
8-azaguanosine + phosphate
show the reaction diagram
-
-
-
r
8-azaguanosine + phosphate
8-azaguanine + alpha-D-ribose 1-phosphate
show the reaction diagram
9-beta-D-arabinosyl-2-fluoroadenine + phosphate
2-fluoroadenine + beta-D-arabinose 1-phosphate
show the reaction diagram
i.e. fludarabine
-
-
r
9-[2-deoxy-beta-D-ribofuranosyl]-6-methylpurine + phosphate
?
show the reaction diagram
-
a toxic prodrug
-
-
?
9-[6-deoxy-beta-L-talofuranosyl]-2-fluoro-adenine + phosphate
?
show the reaction diagram
-
a toxic prodrug, substrate of enzyme mutant M64V, the drug product has anti-tumor activity
-
-
?
9-[6-deoxy-beta-L-talofuranosyl]-6-methylpurine + phosphate
?
show the reaction diagram
-
a toxic prodrug, substrate of enzyme mutant M64V, the drug product has anti-tumor activity
-
-
?
9-[beta-D-arabinofuranosyl]-2-fluoro-adenine + phosphate
?
show the reaction diagram
-
a toxic prodrug
-
-
?
9-[beta-L-lyxofuranosyl]-2-fluoro-adenine + phosphate
?
show the reaction diagram
-
a toxic prodrug, substrate of enzyme mutant M64V, the drug product has anti-tumor activity
-
-
?
adenosine + phosphate
adenine + alpha-D-ribose 1-phosphate
show the reaction diagram
guanine + alpha-D-ribose 1-phosphate
guanosine + phosphate
show the reaction diagram
guanosine + phosphate
guanine + alpha-D-ribose 1-phosphate
show the reaction diagram
inosine + phosphate
hypoxanthine + alpha-D-ribose 1-phosphate
show the reaction diagram
nicotinamide riboside + phosphate
nicotinamide + alpha-D-ribose 1-phosphate
show the reaction diagram
-
-
-
r
purine deoxyribonucleoside + phosphate
purine + 2-deoxy-alpha-D-ribose 1-phosphate
show the reaction diagram
purine ribonucleoside + phosphate
purine + alpha-D-ribose 1-phosphate
show the reaction diagram
xanthosine + phosphate
xanthine + alpha-D-ribose 1-phosphate
show the reaction diagram
additional information
?
-