2.4.2.10: orotate phosphoribosyltransferase

This is an abbreviated version!
For detailed information about orotate phosphoribosyltransferase, go to the full flat file.

Reaction

Synonyms

More, OMP synthase, OPRT, OPRTase, orotate phosphoribosyl pyrophosphate transferase, orotate phosphoribosyl transferase, orotate phosphoribosyltransferase, orotate PRTase, orotic acid phosphoribosyltransferase, orotidine 5'-monophosphate pyrophosphorylase, orotidine 5'-phosphate pyrophosphorylase, orotidine monophosphate pyrophosphorylase, orotidine phosphoribosyltransferase, orotidine-5'-phosphate pyrophosphorylase, orotidylate phosphoribosyltransferase, orotidylate pyrophosphorylase, orotidylic acid phosphorylase, orotidylic acid pyrophosphorylase, orotidylic phosphorylase, orotidylic pyrophosphorylase, phosphoribosyltransferase, orotate, Pyr5, PyrE, rv0382c, type I phosphoribosyltransferase, ura5

ECTree

     2 Transferases

         2.4 Glycosyltransferases

             2.4.2 Pentosyltransferases

                2.4.2.10 orotate phosphoribosyltransferase

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Results	in table
1	Activating Compound
44599	AA Sequence
10	Application
1	CAS Registry Number
28	Cloned(Commentary)
9	Crystallization (Commentary)
1113	Disease/ Diagnostics
6	Expression
4	General Information
9	General Stability
136	Inhibitors
18	kcat/KM [mM/s]
93	Ki Value [mM]
93	KM Value [mM]
12	Localization
40	Metals/Ions
35	Molecular Weight [Da]
36	Natural Substrates/ Products (Substrates)
94	Organism
8	Pathway
108	PDB ID
15	pH Optimum
4	pH Range
2	pH Stability
2	pI Value
12	Protein Variants
31	Purification (Commentary)
8	Reaction
1	Reaction Type
91	Reference
52	Source Tissue
30	Specific Activity [micromol/min/mg]
11	Storage Stability
103	Substrates and Products (Substrate)
28	Subunits
98	Synonyms
1	Systematic Name
12	Temperature Optimum [°C]
3	Temperature Stability [°C]
29	Turnover Number [1/s]

pH Optimum

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pH Optimum on EC 2.4.2.10 - orotate phosphoribosyltransferase

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pH OPTIMUM

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

10

Rhizobium leguminosarum

-

recombinant enzyme

489733

10.5 - 11.5

Corynebacterium ammoniagenes

-

forward (phosphoribosyl transfer) reaction

687400

5.5 - 6.5

Corynebacterium ammoniagenes

-

reverse (pyrophosphorolysis) reaction

687400

7 - 7.5

Mus musculus

-

preferred buffer: Tris-HCl, when substrates are non-saturating, phosphate buffer, when substrate are saturating, not: maleate, imidazole, N-tris[hydroxymethyl] methyl-2-aminoethane-sulfonic acid (i.e. TES) or 3-[N-morpholino]-2-hydroxypropanesulfonic acid (i.e. MOPS) buffer

489712

7.4

Homo sapiens

-

assay at

676270

7.5

Homo sapiens

-

assay at

674045

7.6

Homo sapiens

-

assay at

673097

7.8

Saccharomyces cerevisiae

-

assay at

672162

8

2 entries

8.5

Escherichia coli

-

mutant

489719

8.5 - 9

Saccharomyces cerevisiae

-

-

489715

9

Thermus thermophilus

-

-

489730

9.5

Escherichia coli

-

wild-type

489719

additional information

Mus musculus

-

2 isozymes: pI: 5.65 (minor form), pI: 5.85 (major form)

489713

8

Homo sapiens

-

assay at

672923

8

Vigna mungo

-

-

489725