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2.4.2.12: nicotinamide phosphoribosyltransferase

This is an abbreviated version!
For detailed information about nicotinamide phosphoribosyltransferase, go to the full flat file.

Word Map on EC 2.4.2.12

Reaction

nicotinamide D-ribonucleotide
+
diphosphate
=
nicotinamide
 +
5-phospho-alpha-D-ribose 1-diphosphate

Synonyms

eNAMPT, extracellular nicotinamide phosphoribosyltrasferase, iNAMPT, Nam phosphoribosyltransferase, NAmPRTase, Nampt, Nampt/PBEF/Visfatin, Nampt/visfatin, NAMPTA, NAMPTB, NAPRT, nicotinamide mononucleotide pyrophosphorylase, nicotinamide mononucleotide synthetase, nicotinamide phosphoribosyl transferase, nicotinamide phosphoribosyltransferase, nicotinamide phosphoribosyltransferase/Visfatin, NMN pyrophosphorylase, NMN synthetase, NMPRTase, PBEF, phosphoribosyltransferase, nicotinamide, pre-B cell colony enhancing factor, pre-B cell colony enhancing factor(PBEF), pre-B cell colony-enhancing factor, pre-B cell colony-enhancing factor (PBEF), pre-B cell colony-enhancing factor 1, pre-B colony enhancing factor, pre-B-cell colony enhancing factor, pre-B-cell colony-enhancing factor, Visfatin

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.2 Pentosyltransferases
                2.4.2.12 nicotinamide phosphoribosyltransferase

Expression

Expression on EC 2.4.2.12 - nicotinamide phosphoribosyltransferase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
administration of 0.1 mM salidroside alleviates Abetax1einduced cell damage and increases the expression level of the enzyme
enzyme expression is decreased by insulin, PI3K and AKT inhibitors, quercetin
enzyme expression is increased by Ox-LDL, CTRP3, glucose, rosiglitazone, adipocyte differentiation, ATP, LPS, CoCl2, ischaemia, OGD, anti-CD38 and differentiation in CCL, oxidative stress (H2O2), hypoxia, TNF-alpha, interleukin-1beta, starvation, and C-peptide
expression of Nampt in the heart is significantly decreased by ischemia, ischemia/reperfusion and pressure overload. Downregulation of Nampt increases caspase 3 cleavage, cytochrome c release, and TUNEL-positive cells, which are inhibited in the presence of Bcl-xL, but do not increase hairpin 2–positive cells, suggesting that endogenous Nampt negatively regulates apoptosis but not necrosis. Downregulation of Nampt also impairs autophagic flux
-
high fat diet reduces enzyme expression in the atrial tissues
increased during macrophage differentiation
-
miR410 directly inhibits enzyme expression
the enzyme is often overexpressed in tumor tissues, including in breast, gastric, pancreatic, colorectal, ovarian, prostate, thyroid and endometrial carcinomas as well as in brain tumors, sarcoma, melanoma and hematological malignancies
the enzyme is significantly upregulated in the ventral tegmental area of cocaine-conditioned mice
the expression level of the enzyme decreases as a result of Abeta1-40x1einduced neuronal toxicity
upon aging: enzyme level increases in serum but decreases in brain, decreases in cortex and hippocampus but remains unchanged in cerebellum and striatum in brain, and increases in microglia but likely decreases in neuron
-