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0.000017
4-chloro-N-[4-[(3-methylbutyl)carbamoyl]phenyl]-1,3-dihydro-2H-isoindole-2-carboxamide
pH and temperature not specified in the publication
0.009
5,6-dimethoxy-N-[4-[(3-methylbutyl)carbamoyl]phenyl]-1,3-dihydro-2H-isoindole-2-carboxamide
Ki above 0.009 mM, pH and temperature not specified in the publication
0.0000049
5-(hydroxymethyl)-N-[4-[(3-methylbutyl)carbamoyl]phenyl]-1,3-dihydro-2H-isoindole-2-carboxamide
pH and temperature not specified in the publication
0.0000017
5-chloro-N-(4-[1-[(2S)-oxolane-2-carbonyl]piperidin-4-yl]phenyl)-1,3-dihydro-2H-isoindole-2-carboxamide
pH and temperature not specified in the publication
0.0000047
5-cyano-N-[4-[(3-methylbutyl)carbamoyl]phenyl]-1,3-dihydro-2H-isoindole-2-carboxamide
pH and temperature not specified in the publication
0.0000079
5-fluoro-N-[4-[(3-methylbutyl)carbamoyl]phenyl]-1,3-dihydro-2H-isoindole-2-carboxamide
pH and temperature not specified in the publication
0.0000094
5-fluoro-N-[4-[1-(1-methylpiperidine-4-carbonyl)piperidin-4-yl]phenyl]-1,3-dihydro-2H-isoindole-2-carboxamide
pH and temperature not specified in the publication
0.0000025
5-fluoro-N-[4-[1-(2-hydroxy-2-methylpropanoyl)piperidin-4-yl]phenyl]-1,3-dihydro-2H-isoindole-2-carboxamide
pH and temperature not specified in the publication
0.000016
5-methoxy-N-[4-[(3-methylbutyl)carbamoyl]phenyl]-1,3-dihydro-2H-isoindole-2-carboxamide
pH and temperature not specified in the publication
0.000013
5-methyl-N-[4-[(3-methylbutyl)carbamoyl]phenyl]-1,3-dihydro-2H-isoindole-2-carboxamide
pH and temperature not specified in the publication
0.00016 - 0.0071
5P-DADMe-NMN
0.000003
GMX1778
pH and temperature not specified in the publication
0.000112
methyl 4-[(1,3-dihydro-2H-isoindole-2-carbonyl)amino]benzoate
pH and temperature not specified in the publication
0.00056
N-(4-carbamoylphenyl)-1,3-dihydro-2H-isoindole-2-carboxamide
pH and temperature not specified in the publication
0.0022
N-(4-methylphenyl)-1,3-dihydro-2H-isoindole-2-carboxamide
pH and temperature not specified in the publication
0.0000015
N-(4-[1-[2-methyl-2-(4-methylpiperazin-1-yl)propanoyl]piperidin-4-yl]phenyl)-1,3-dihydro-2H-isoindole-2-carboxamide
pH and temperature not specified in the publication
0.000019
N-(4-[[(2S)-1-hydroxy-4-methylpentan-2-yl]carbamoyl]phenyl)-1,3-dihydro-2H-isoindole-2-carboxamide
pH and temperature not specified in the publication
0.000013
N-(4-[[(oxan-3-yl)methyl]carbamoyl]phenyl)-1,3-dihydro-2H-isoindole-2-carboxamide
pH and temperature not specified in the publication
0.000024
N-(4-[[(oxolan-3-yl)methyl]carbamoyl]phenyl)-1,3-dihydro-2H-isoindole-2-carboxamide
pH and temperature not specified in the publication
0.000018
N-(4-[[1-(2-methylbutanoyl)piperidin-4-yl]oxy]phenyl)-1,3-dihydro-2H-isoindole-2-carboxamide
pH and temperature not specified in the publication
0.0089
N-[3-[(3-methylbutyl)carbamoyl]phenyl]-1,3-dihydro-2H-isoindole-2-carboxamide
Ki above 0.0089 mM, pH and temperature not specified in the publication
0.000003
N-[4-(1-benzoyl-1,2,3,6-tetrahydropyridin-4-yl)phenyl]-1,3-dihydro-2H-isoindole-2-carboxamide
pH and temperature not specified in the publication
0.0000019
N-[4-(1-benzoylazetidin-3-yl)phenyl]-5-fluoro-1,3-dihydro-2H-isoindole-2-carboxamide
pH and temperature not specified in the publication
0.0000016
N-[4-(1-benzoylpiperidin-4-yl)butyl]-1,3-dihydro-2H-isoindole-2-carboxamide
pH and temperature not specified in the publication
0.000001
N-[4-(1-benzoylpiperidin-4-yl)phenyl]-1,3-dihydro-2H-isoindole-2-carboxamide
pH and temperature not specified in the publication
0.000019
N-[4-(4-benzoylpiperazin-1-yl)phenyl]-1,3-dihydro-2H-isoindole-2-carboxamide
pH and temperature not specified in the publication
0.000021
N-[4-(benzenesulfonyl)phenyl]-1,3-dihydro-2H-isoindole-2-carboxamide
pH and temperature not specified in the publication
0.000019
N-[4-(benzylcarbamoyl)phenyl]-1,3-dihydro-2H-isoindole-2-carboxamide
pH and temperature not specified in the publication
0.000104
N-[4-(propylcarbamoyl)phenyl]-1,3-dihydro-2H-isoindole-2-carboxamide
pH and temperature not specified in the publication
0.00016
N-[4-[(3,3-dimethylbutyl)(methyl)carbamoyl]phenyl]-1,3-dihydro-2H-isoindole-2-carboxamide
pH and temperature not specified in the publication
0.000014
N-[4-[(3,3-dimethylbutyl)carbamoyl]phenyl]-1,3-dihydro-2H-isoindole-2-carboxamide
pH and temperature not specified in the publication
0.000011
N-[4-[(3-methylbutyl)carbamoyl]phenyl]-1,3-dihydro-2H-isoindole-2-carboxamide
pH and temperature not specified in the publication
0.0000075
N-[4-[(3-methylbutyl)carbamoyl]phenyl]-1,3-dihydro-2H-pyrrolo[3,4-c]pyridine-2-carboxamide
pH and temperature not specified in the publication
0.000023
N-[4-[(3-methylbutyl)carbamoyl]phenyl]-5-(trifluoromethyl)-1,3-dihydro-2H-isoindole-2-carboxamide
pH and temperature not specified in the publication
0.00035
N-[4-[(3-methylbutyl)sulfamoyl]phenyl]-1,3-dihydro-2H-isoindole-2-carboxamide
pH and temperature not specified in the publication
0.000009
N-[4-[(3-phenylpropyl)carbamoyl]phenyl]-1,3-dihydro-2H-isoindole-2-carboxamide
pH and temperature not specified in the publication
0.000058
N-[4-[(4-methylpentanoyl)amino]phenyl]-1,3-dihydro-2H-isoindole-2-carboxamide
pH and temperature not specified in the publication
0.0000043
N-[4-[1-(1-methylcyclopropane-1-carbonyl)piperidin-4-yl]phenyl]-1,3-dihydro-2H-isoindole-2-carboxamide
pH and temperature not specified in the publication
0.000015
N-[4-[1-(2-methylpropanoyl)piperidin-4-yl]phenyl]-1,3-dihydro-2H-isoindole-2-carboxamide
pH and temperature not specified in the publication
0.0000056
N-[4-[1-(3-hydroxy-3-methylbutanoyl)piperidin-4-yl]phenyl]-1,3-dihydro-2H-isoindole-2-carboxamide
pH and temperature not specified in the publication
0.000023
N-[4-[1-(3-methylbutyl)-1H-pyrazol-4-yl]phenyl]-1,3-dihydro-2H-isoindole-2-carboxamide
pH and temperature not specified in the publication
0.0000051
N-[4-[1-(3-methyloxetane-3-carbonyl)piperidin-4-yl]phenyl]-1,3-dihydro-2H-isoindole-2-carboxamide
pH and temperature not specified in the publication
0.0000039
N-[4-[1-(cyclopropanesulfonyl)piperidin-4-yl]phenyl]-5-fluoro-1,3-dihydro-2H-isoindole-2-carboxamide
pH and temperature not specified in the publication
0.000014
N-[4-[4-(pyridin-2-yl)piperazine-1-carbonyl]phenyl]-1,3-dihydro-2H-isoindole-2-carboxamide
pH and temperature not specified in the publication
0.0000054
N-[5-[(3-methylbutyl)carbamoyl]pyridin-2-yl]-1,3-dihydro-2H-isoindole-2-carboxamide
pH and temperature not specified in the publication
0.000057
N-[6-[(3-methylbutyl)carbamoyl]pyridin-3-yl]-1,3-dihydro-2H-isoindole-2-carboxamide
pH and temperature not specified in the publication
0.000487
N-[[4-(benzenesulfonyl)phenyl]methyl]-1,3-dihydro-2H-isoindole-2-carboxamide
pH and temperature not specified in the publication
0.00025 - 0.003
nicotinamide
additional information
ATP
0.00016
5P-DADMe-NMN
with respect to alpha-D-5-phosphoribosyl 1-diphosphate (PRPP), in presence of 2.5 mM ATP, KM/Ki = 4, 200 microM PRPP, 100 nM nicotinamide, 2.2 nM NAMPT, 15 min
0.00053
5P-DADMe-NMN
with respect to alpha-D-5-phosphoribosyl 1-diphosphate (PRPP), in absence of ATP, KM/Ki = 14, 100 microM PRPP, 1 microM nicotinamide, 88 nM NAMPT, 15 min
0.0025
5P-DADMe-NMN
with respect to nicotinamide, in presence of 2.5 mM ATP, KM/Ki <1, 200 microM PRPP, 100 nM nicotinamide, 2.2 nM NAMPT, 15 min
0.0071
5P-DADMe-NMN
with respect to nicotinamide, in absence of ATP, KM/Ki <1, 100 microM PRPP, 1 microM nicotinamide, 88 nM NAMPT, 15 min
0.000003
FK866
pH and temperature not specified in the publication
0.0003
FK866
-
free enzyme
0.0004
FK866
-
enzyme-substrate complex
0.00014
NAD+
with respect to alpha-D-5-phosphoribosyl 1-diphosphate (PRPP), in presence of 2.5 mM ATP, KM/Ki = 5, 200 microM PRPP, 100 nM nicotinamide, 2.2 nM NAMPT, 15 min
0.0021
NAD+
with respect to nicotinamide, in presence of 2.5 mM ATP, KM/Ki <1, 200 microM PRPP, 100 nM nicotinamide, 2.2 nM NAMPT, 15 min
0.00022
NADH
with respect to alpha-D-5-phosphoribosyl 1-diphosphate (PRPP), in presence of 2.5 mM ATP, KM/Ki = 3, 200 microM PRPP, 100 nM nicotinamide, 2.2 nM NAMPT, 15 min
0.0032
NADH
with respect to nicotinamide, in presence of 2.5 mM ATP, KM/Ki <1, 200 microM PRPP, 100 nM nicotinamide, 2.2 nM NAMPT, 15 min
0.00025
nicotinamide
NMN synthesis
0.003
nicotinamide
NMN synthesis, in presence of 5 microM NAD+
additional information
ATP
> 4 mM, inhibition of NMN synthesis by phosphorylated NAMPT
additional information
ATP
-
> 4 mM, inhibition of NMN synthesis by phosphorylated NAMPT
additional information
FK866
10 +/-1 pM, with respect to alpha-D-5-phosphoribosyl 1-diphosphate (PRPP), in presence of 2.5 mM ATP, KM/Ki = 63000, 200 microM PRPP, 100 nM nicotinamide, 2.2 nM NAMPT, 15 min
additional information
FK866
-
10 +/-1 pM, with respect to alpha-D-5-phosphoribosyl 1-diphosphate (PRPP), in presence of 2.5 mM ATP, KM/Ki = 63000, 200 microM PRPP, 100 nM nicotinamide, 2.2 nM NAMPT, 15 min
additional information
FK866
150 +/-18 pM, with respect to nicotinamide, in presence of 2.5 mM ATP, KM/Ki = 33, 200 microM PRPP, 100 nM nicotinamide, 2.2 nM NAMPT, 15 min
additional information
FK866
-
150 +/-18 pM, with respect to nicotinamide, in presence of 2.5 mM ATP, KM/Ki = 33, 200 microM PRPP, 100 nM nicotinamide, 2.2 nM NAMPT, 15 min
additional information
FK866
5000 +/-500 pM, with respect to nicotinamide, in absence of ATP, KM/Ki = 171, 100 microM PRPP, 1 microM nicotinamide, 88 nM NAMPT, 15 min
additional information
FK866
-
5000 +/-500 pM, with respect to nicotinamide, in absence of ATP, KM/Ki = 171, 100 microM PRPP, 1 microM nicotinamide, 88 nM NAMPT, 15 min
additional information
FK866
730 +/-75 pM, with respect to alpha-D-5-phosphoribosyl 1-diphosphate (PRPP), in absence of ATP, KM/Ki = 9863, 100 microM PRPP, 1 microM nicotinamide, 88 nM NAMPT, 15 min
additional information
FK866
-
730 +/-75 pM, with respect to alpha-D-5-phosphoribosyl 1-diphosphate (PRPP), in absence of ATP, KM/Ki = 9863, 100 microM PRPP, 1 microM nicotinamide, 88 nM NAMPT, 15 min
additional information
NAD+
> 100 microM, with respect to nicotinamide, in absence of ATP
additional information
NAD+
-
> 100 microM, with respect to nicotinamide, in absence of ATP
additional information
NADH
> 100 microM, with respect to nicotinamide, in absence of ATP
additional information
NADH
-
> 100 microM, with respect to nicotinamide, in absence of ATP