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2.4.2.18: anthranilate phosphoribosyltransferase

This is an abbreviated version!
For detailed information about anthranilate phosphoribosyltransferase, go to the full flat file.

Word Map on EC 2.4.2.18

Reaction

N-(5-phospho-D-ribosyl)-anthranilate
+
diphosphate
=
anthranilate
+
5-phospho-alpha-D-ribose 1-diphosphate

Synonyms

AnPRT, anthranilate 5-phosphoribosylpyrophosphate phosphoribosyltransferase, anthranilate phosphoribosyl transferase, anthranilate phosphoribosylpyrophosphate phosphoribosyltransferase, anthranilate phosphoribosyltransferase, anthranilate PRT, anthranilate-5-phosphoribosylphosphate phosphoribosyltransferase, anthranilate-PP-ribose-P phosphoribosyltransferase, More, Pat, phosphoribosyl-anthranilate pyrophosphorylase, phosphoribosylanthranilate pyrophosphorylase, phosphoribosylanthranilate transferase, phosphoribosyltransferase, anthranilate, PR transferase, PRT, sAnPRT, ssAnPRT, SSO0890, ssTrpD, strpD, Trp D, TrpD, TTC1491

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.2 Pentosyltransferases
                2.4.2.18 anthranilate phosphoribosyltransferase

Reference

Reference on EC 2.4.2.18 - anthranilate phosphoribosyltransferase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Largen, M.; Belser, W.L.
Tryptophan biosynthetic pathway in the Enterobacteriaceae: some physical properties of the enzymes
J. Bacteriol.
121
239-249
1975
Enterobacter cloacae, Aeromonas caviae, Citrobacter freundii, Hafnia alvei, Enterobacter liquefaciens, Pectobacterium carotovorum, Enterobacter cloacae subsp. dissolvens, Morganella morganii, Proteus vulgaris, Serratia marcescens, Serratia rubidaea
Manually annotated by BRENDA team
Ito, J.; Yanofsky, C.
Anthranilate synthetase, an enzyme specified by the tryptophan operon of Escherichia coli: Comparative studies on the complex and the subunits
J. Bacteriol.
97
734-742
1969
Escherichia coli
Manually annotated by BRENDA team
Wegman, J.; DeMoss, J.A.
The enzymatic conversion of anthranilate to indolylglycerol phosphate in Neurospora crassa
J. Biol. Chem.
240
3781-3788
1965
Neurospora crassa
Manually annotated by BRENDA team
Grieshaber, M.
On the evolution of a oligocephalic enzyme. Glutamine-chorismate-amidotransferase-free anthranilate phosphoribosyltransferases from mutant strains of Salmonella typhimurium
Z. Naturforsch. C
33c
235-244
1978
Salmonella enterica subsp. enterica serovar Typhimurium
-
Manually annotated by BRENDA team
Hommel, U.; Lustig, A.; Kirschner, K.
Purification and characterization of yeast anthranilate phosphoribosyltransferase
Eur. J. Biochem.
180
33-40
1989
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Gonzalez, J.E.; Sommerville, R.L.
The anthranilate aggregate of Escherichia coli: kinetics of inhibition by tryptophan of phosphoribosyltransferase
Biochem. Cell Biol.
64
681-691
1986
Escherichia coli
Manually annotated by BRENDA team
Kane, J.F.; Jensen, R.A.
Metabolic interlock. The influence of histidine on tryptophan biosynthesis in Bacillus subtilis
J. Biol. Chem.
245
2384-2390
1970
Ogataea henricii
Manually annotated by BRENDA team
Bode, R.; Birnbaum, D.
Enzymes of the aromatic amino acid biosynthesis in Hansenula henricii: anthranilate phosphoribosylpyrophosphate-phosphoribosyltransferase (E.C.2.4.2.18)
Z. Allg. Mikrobiol.
18
559-566
1978
Ogataea henricii
Manually annotated by BRENDA team
Henderson, E.J.; Zalkin, H.; Hwang, L.H.
The anthranilate synthetase-anthranilate 5-phosphoribosylpyrophosphate phosphoribosyltransferase aggregate. Catalytic and regulatory properties of aggregated and unaggregated forms of anthranilate 5-phosphoribosylpyrophosphate phosphoribosyltransferase
J. Biol. Chem.
245
1424-1431
1970
Salmonella enterica subsp. enterica serovar Typhimurium
Manually annotated by BRENDA team
Grieshaber, M.; Bauerle, R.
Monomeric and dimeric forms of component II of the anthranilate synthetase-anthranilate 5-phosphoribosylpyrophosphate phosphoribosyltransferase complex of Salmonella typhimurium. Implications concerning the mode of assembly of the complex
Biochemistry
13
373-383
1974
Salmonella enterica subsp. enterica serovar Typhimurium
Manually annotated by BRENDA team
Largen, M.; Mills, S.E.; Rowe, J.; Yanofsky, C.
Purification, subunit structure and partial amino-acid sequence of anthranilate-5-phosphoribosylpyrophosphate phosphoribosyltransferase from the enteric bacterium Serratia marcescens
Eur. J. Biochem.
67
31-36
1976
Serratia marcescens
Manually annotated by BRENDA team
Egan, A.F.; Gibson, F.
Anthranilate synthase-anthranilate 5-phosphoribosyl 1-pyrophosphate phosphoribosyltransferase from Aerobacter aerogenes
Biochem. J.
130
847-859
1972
Klebsiella aerogenes, Escherichia coli
Manually annotated by BRENDA team
Marcus, S.L.; Balbinder, E.
Purification of anthranilate 5-phosphoribosylpyrophosphate phosphoribosyltransferase from Salmonella typhimurium using affinity chromatography: resolution of monomeric and dimeric forms
Biochem. Biophys. Res. Commun.
47
438-444
1972
Salmonella enterica subsp. enterica serovar Typhimurium
Manually annotated by BRENDA team
Edwards, S.E.; Kraut, J.; Xuong, N.; Ashford, V.; Halloran, T.P.; Mills, S.L.
Crystallization and purification of the enzyme anthranilate phosphoribosyl transferase
J. Mol. Biol.
203
523-524
1988
Hafnia alvei
Manually annotated by BRENDA team
Largen, M.; Mills, S.E.; Rowe, J.; Yanofsky, C.
Purification and properties of a third form of anthranilate-5-phosphoribosylpyrophosphate phosphoribosyltransferase from the Enterobacteriaceae
J. Biol. Chem.
253
409-412
1978
Pectobacterium carotovorum
Manually annotated by BRENDA team
Ivens, A.; Mayans, O.; Szadkowski, H.; Wilmanns, M.; Kirschner, K.
Purification, characterization and crystallization of thermostable anthranilate phosphoribosyltransferase from Sulfolobus solfataricus
Eur. J. Biochem.
268
2246-2252
2001
Saccharolobus solfataricus, Saccharolobus solfataricus (P50384)
Manually annotated by BRENDA team
Kim, C.; Xuong, N.H.; Edwards, S.; Madhusudan; Yee, M.C.; Spraggon, G.; Mills, S.E.
The crystal structure of anthranilate phosphoribosyltransferase from the enterobacterium Pectobacterium carotovorum
FEBS Lett.
523
239-246
2002
Pectobacterium carotovorum
Manually annotated by BRENDA team
O'Gara, J.P.; Dunican, L.K.
Mutations in the trpD gene of Corynebacterium glutamicum confer 5-methyltryptophan resistance by encoding a feedback-resistant anthranilate phosphoribosyltransferase
Appl. Environ. Microbiol.
61
4477-4479
1995
Corynebacterium glutamicum
Manually annotated by BRENDA team
Ramos, I.; Downs, D.M.
Anthranilate synthase can generate sufficient phosphoribosyl amine for thiamine synthesis in Salmonella enterica
J. Bacteriol.
185
5125-5132
2003
Salmonella enterica
Manually annotated by BRENDA team
Denby, K.J.; Jason, L.J.; Murray, S.L.; Last, R.L.
ups1, an Arabidopsis thaliana camalexin accumulation mutant defective in multiple defence signalling pathways
Plant J.
41
673-684
2005
Arabidopsis thaliana
Manually annotated by BRENDA team
Browne, B.A.; Ramos, A.I.; Downs, D.M.
PurF-independent phosphoribosyl amine formation in yjgF mutants of Salmonella enterica utilizes the tryptophan biosynthetic enzyme complex anthranilate synthase-phosphoribosyltransferase
J. Bacteriol.
188
6786-6792
2006
Salmonella enterica
Manually annotated by BRENDA team
Marino, M.; Deuss, M.; Svergun, D.I.; Konarev, P.V.; Sterner, R.; Mayans, O.
Structural and mutational analysis of substrate complexation by anthranilate phosphoribosyltransferase from Sulfolobus solfataricus
J. Biol. Chem.
281
21410-21421
2006
Saccharolobus solfataricus (P50384), Saccharolobus solfataricus
Manually annotated by BRENDA team
Schwab, T.; Skegro, D.; Mayans, O.; Sterner, R.
A rationally designed monomeric variant of anthranilate phosphoribosyltransferase from Sulfolobus solfataricus is as active as the dimeric wild-type enzyme but less thermostable
J. Mol. Biol.
376
506-516
2008
Saccharolobus solfataricus (P50384), Saccharolobus solfataricus
Manually annotated by BRENDA team
Schlee, S.; Deuss, M.; Bruning, M.; Ivens, A.; Schwab, T.; Hellmann, N.; Mayans, O.; Sterner, R.
Activation of anthranilate phosphoribosyltransferase from Sulfolobus solfataricus by removal of magnesium inhibition and acceleration of product release
Biochemistry
48
5199-5209
2009
Saccharolobus solfataricus (P50384), Saccharolobus solfataricus
Manually annotated by BRENDA team
Lambrecht, J.A.; Downs, D.M.
Anthranilate phosphoribosyl transferase (TrpD) generates phosphoribosylamine for thiamine synthesis from enamines and phosphoribosyl pyrophosphate
ACS Chem. Biol.
8
242-248
2013
Salmonella enterica
Manually annotated by BRENDA team
Schwab, T.; Sterner, R.
Stabilization of a metabolic enzyme by library selection in Thermus thermophilus
Chembiochem
12
1581-1588
2011
Saccharolobus solfataricus (P50384), Saccharolobus solfataricus, Saccharolobus solfataricus P2 (P50384)
Manually annotated by BRENDA team
Mayans, O.; Ivens, A.; Nissen, L.J.; Kirschner, K.; Wilmanns, M.
Structural analysis of two enzymes catalysing reverse metabolic reactions implies common ancestry
EMBO J.
21
3245-3254
2002
Saccharolobus solfataricus (P50384), Saccharolobus solfataricus P2 (P50384)
Manually annotated by BRENDA team
Cookson, T.V.; Castell, A.; Bulloch, E.M.; Evans, G.L.; Short, F.L.; Baker, E.N.; Lott, J.S.; Parker, E.J.
Alternative substrates reveal catalytic cycle and key binding events in the reaction catalysed by anthranilate phosphoribosyltransferase from Mycobacterium tuberculosis
Biochem. J.
461
87-98
2014
Mycobacterium tuberculosis (P9WFX5), Mycobacterium tuberculosis
Manually annotated by BRENDA team
Castell, A.; Short, F.L.; Evans, G.L.; Cookson, T.V.; Bulloch, E.M.; Joseph, D.D.; Lee, C.E.; Parker, E.J.; Baker, E.N.; Lott, J.S.
The substrate capture mechanism of Mycobacterium tuberculosis anthranilate phosphoribosyltransferase provides a mode for inhibition
Biochemistry
52
1776-1787
2013
Mycobacterium tuberculosis (P9WFX5), Mycobacterium tuberculosis
Manually annotated by BRENDA team
Cookson, T.V.; Evans, G.L.; Castell, A.; Baker, E.N.; Lott, J.S.; Parker, E.J.
Structures of Mycobacterium tuberculosis anthranilate phosphoribosyltransferase variants reveal the conformational changes that facilitate delivery of the substrate to the active site
Biochemistry
54
6082-6092
2015
Mycobacterium tuberculosis (P9WFX5), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WFX5)
Manually annotated by BRENDA team
Kuepper, J.; Dickler, J.; Biggel, M.; Behnken, S.; Jaeger, G.; Wierckx, N.; Blank, L.M.
Metabolic engineering of Pseudomonas putida KT2440 to produce anthranilate from glucose
Front. Microbiol.
6
1310
2015
Pseudomonas putida, Pseudomonas putida KT 2240
Manually annotated by BRENDA team
Evans, G.L.; Furkert, D.P.; Abermil, N.; Kundu, P.; de Lange, K.M.; Parker, E.J.; Brimble, M.A.; Baker, E.N.; Lott, J.S.
Datasets, processing and refinement details for Mtb-AnPRT inhibitor structures with various space groups
Data Brief
15
1019-1029
2017
Mycobacterium tuberculosis (A5U4M0)
Manually annotated by BRENDA team
Kubota, T.; Matsushita, H.; Tomita, T.; Kosono, S.; Yoshida, M.; Kuzuyama, T.; Nishiyama, M.
Novel stand-alone RAM domain protein-mediated catalytic control of anthranilate phosphoribosyltransferase in tryptophan biosynthesis in Thermus thermophilus
Extremophiles
21
73-83
2017
Thermus thermophilus
Manually annotated by BRENDA team
Perveen, S.; Rashid, N.; Tang, X.F.; Imanaka, T.; Papageorgiou, A.C.
Anthranilate phosphoribosyltransferase from the hyperthermophilic archaeon Thermococcus kodakarensis shows maximum activity with zinc and forms a unique dimeric structure
FEBS Open Bio
7
1217-1230
2017
Thermococcus kodakarensis (Q9YGB4), Thermococcus kodakarensis
Manually annotated by BRENDA team
Schlee, S.; Straub, K.; Schwab, T.; Kinateder, T.; Merkl, R.; Sterner, R.
Prediction of quaternary structure by analysis of hot spot residues in protein-protein interfaces the case of anthranilate phosphoribosyltransferases
Proteins
87
815-825
2019
Acetomicrobium mobile, Coprococcus eutactus, Fructobacillus fructosus, Methanocella conradii, Methanococcus voltae, Pelodictyon luteolum, Pelodictyon luteolum DSM270, Petrotoga mobilis, Saccharolobus solfataricus (P50384), Saccharolobus solfataricus P2 (P50384), Staphylococcus aureus, Staphylococcus aureus USA300, Staphylococcus haemolyticus, Staphylococcus haemolyticus JCSC1435
Manually annotated by BRENDA team