2.4.2.19: nicotinate-nucleotide diphosphorylase (carboxylating)

This is an abbreviated version!
For detailed information about nicotinate-nucleotide diphosphorylase (carboxylating), go to the full flat file.

Word Map on EC 2.4.2.19

2.4.2.19

nicotinic

3-hydroxyanthranilic

phthalic

tiazofurin

excitotoxin

kynureninase

5-phosphoribosyl-1-pyrophosphate

4.1.1.45

phosphoribosyltransferases

prtases

aminocarboxymuconate-semialdehyde

Reaction

Synonyms

BNA6, general stress protein 70 , GSP70 , Hp-QAPRTase, hQPRTase, M6_Spy1061, NAD pyrophosphorylase, NadC, nicotinate mononucleotide pyrophosphorylase (carboxylating) (EC 2.4.2.19), nicotinate-nucleotide pyrophosphorylase (carboxylating), nicotinate-nucleotide:pyrophosphate phospho-alpha-D-ribosyltransferase (decarboxylating), pyrophosphorylase, nicotinate mononucleotide (carboxylating), QAPRTase, QPRT, QPRTase, QPRTase , QPT, QPT1, QPT2, quinolate phosphoribosyltransferase, quinolinate phosphoribosyl transferase, quinolinate phosphoribosyltansferase, quinolinate phosphoribosyltransferase, quinolinate phosphoribosyltransferase (decarboxylating), quinolinate phosphoribosyltransferase 1, quinolinate phosphoribosyltransferase 2, quinolinate phosphoribosyltransferase [decarboxylating] , quinolinic acid phosphoribosyl transferase, quinolinic acid phosphoribosyltransferase, quinolinic phosphoribosyltransferase, sp.NadC, spNadC, TM1645, type II quinolic acid phosphoribosyltransferase, type II quinolinic acid phosphoribosyltransferase

ECTree

2 Transferases

2.4 Glycosyltransferases

2.4.2 Pentosyltransferases

2.4.2.19 nicotinate-nucleotide diphosphorylase (carboxylating)

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Results	in table
2	Activating Compound
35111	AA Sequence
1	CAS Registry Number
19	Cloned(Commentary)
1	Cofactor
18	Crystallization (Commentary)
62	Disease/ Diagnostics
2	Expression
7	General Information
4	IC50 Value
114	Inhibitors
23	kcat/KM [mM/s]
10	Ki Value [mM]
62	KM Value [mM]
27	Metals/Ions
36	Molecular Weight [Da]
33	Natural Substrates/ Products (Substrates)
59	Organism
10	Pathway
123	PDB ID
14	pH Optimum
3	pH Range
3	pH Stability
1	pI Value
1	Posttranslational Modification
31	Protein Variants
25	Purification (Commentary)
5	Reaction
2	Reaction Type
58	Reference
39	Source Tissue
23	Specific Activity [micromol/min/mg]
4	Storage Stability
74	Substrates and Products (Substrate)
27	Subunits
81	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
4	Temperature Stability [°C]
20	Turnover Number [1/s]

Specific Activity

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Specific Activity on EC 2.4.2.19 - nicotinate-nucleotide diphosphorylase (carboxylating)

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0.0006

Salmonella enterica subsp. enterica serovar Typhimurium

wild-type with nicotinic acid at 1 mM and 2 mM 5-phospho-alpha-D-ribose 1-diphosphate

0.01235

0.0133

enzyme from liver

0.0187

enzyme from brain

0.0227 - 0.0919

enzyme from kidney

0.05169

0.0517

0.07

Salmonella enterica subsp. enterica serovar Typhimurium

mutant R152A with nicotinic acid at 1 mM and 2 mM 5-phospho-alpha-D-ribose 1-diphosphate

0.073

0.09

wild-type, 0.1 mM 5-phospho-alpha-D-ribose 1-diphosphate, UV-based assay measuring nicotinic acid mononucleotide formation at 266 nm, 30 min, 37°C, same order of magnitude as bacterial enzymes, 100% relative activity

693620

0.091

Sus scrofa

638028

0.1

Salmonella enterica subsp. enterica serovar Typhimurium

mutant R152A with quinolinic acid at 1 mM and 2 mM 5-phospho-alpha-D-ribose 1-diphosphate

702359

0.2

Mycobacterium tuberculosis

P9WJJ7

cell extract, at pH 7.2 and 37°C

0.75

0.88

0.9

Salmonella enterica subsp. enterica serovar Typhimurium

638022

1.2

2 entries

additional information

7 entries