2.4.2.19: nicotinate-nucleotide diphosphorylase (carboxylating) This is an abbreviated version! For detailed information about nicotinate-nucleotide diphosphorylase (carboxylating), go to the full flat file .
Word Map on EC 2.4.2.19
Reaction
beta-nicotinate D-ribonucleotide +
diphosphate +
CO2 =
pyridine-2,3-dicarboxylate +
5-phospho-alpha-D-ribose 1-diphosphate
Synonyms BNA6, general stress protein 70 , GSP70 , Hp-QAPRTase, hQPRTase, M6_Spy1061, NAD pyrophosphorylase, NadC, nicotinate mononucleotide pyrophosphorylase (carboxylating) (EC 2.4.2.19), nicotinate-nucleotide pyrophosphorylase (carboxylating), nicotinate-nucleotide:pyrophosphate phospho-alpha-D-ribosyltransferase (decarboxylating), pyrophosphorylase, nicotinate mononucleotide (carboxylating), QAPRTase, QPRT, QPRTase, QPRTase , QPT, QPT1, QPT2, quinolate phosphoribosyltransferase, quinolinate phosphoribosyl transferase, quinolinate phosphoribosyltansferase, quinolinate phosphoribosyltransferase, quinolinate phosphoribosyltransferase (decarboxylating), quinolinate phosphoribosyltransferase 1, quinolinate phosphoribosyltransferase 2, quinolinate phosphoribosyltransferase [decarboxylating] , quinolinic acid phosphoribosyl transferase, quinolinic acid phosphoribosyltransferase, quinolinic phosphoribosyltransferase, sp.NadC, spNadC, TM1645, type II quinolic acid phosphoribosyltransferase, type II quinolinic acid phosphoribosyltransferase
ECTree
Subunits
Subunits on EC 2.4.2.19 - nicotinate-nucleotide diphosphorylase (carboxylating)
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octamer
-
8 * 27500, SDS-PAGE
?
x * 35000, SDS-PAGE
?
-
x * 34200, equilibrium sedimentation in guanidine HCl
?
x * 30048, crystal structure, residues 1-273
?
-
x * 30048, crystal structure, residues 1-273
-
dimer
2 * 36000, SDS-PAGE
dimer
-
2 * 35000, SDS-PAGE
dimer
-
2 * 35000, SDS-PAGE
dimer
-
wild-type and mutants, gel filtration
hexamer
Hp-QAPRTase forms a hexamer with a - trimer of dimers - configuration
hexamer
x-ray crystallography
hexamer
-
x-ray crystallography
hexamer
according to gel filtration, 3 canonical (AB) dimers (formed by two-fold rotation placing N-terminus of monomer A next to C-terminus of monomer B) related to each other by 3-fold rotation axis, hexameric D3 symmetry, active sites in close proximity at interface between monomers A and monomers B
hexamer
6 * 191000, dynamic light scattering analysis
hexamer
M1KCW7
6 * 33000, X-ray crystallography
homohexamer
-
gel filtration
homohexamer
-
gel filtration
pentamer
-
5 * 34000, SDS-PAGE
pentamer
-
5 * 32000, SDS-PAGE