2.4.2.19: nicotinate-nucleotide diphosphorylase (carboxylating) This is an abbreviated version! For detailed information about nicotinate-nucleotide diphosphorylase (carboxylating), go to the full flat file .
Word Map on EC 2.4.2.19
Reaction
beta-nicotinate D-ribonucleotide +
diphosphate +
CO2 =
pyridine-2,3-dicarboxylate +
5-phospho-alpha-D-ribose 1-diphosphate
Synonyms BNA6, general stress protein 70 , GSP70 , Hp-QAPRTase, hQPRTase, M6_Spy1061, NAD pyrophosphorylase, NadC, nicotinate mononucleotide pyrophosphorylase (carboxylating) (EC 2.4.2.19), nicotinate-nucleotide pyrophosphorylase (carboxylating), nicotinate-nucleotide:pyrophosphate phospho-alpha-D-ribosyltransferase (decarboxylating), pyrophosphorylase, nicotinate mononucleotide (carboxylating), QAPRTase, QPRT, QPRTase, QPRTase , QPT, QPT1, QPT2, quinolate phosphoribosyltransferase, quinolinate phosphoribosyl transferase, quinolinate phosphoribosyltansferase, quinolinate phosphoribosyltransferase, quinolinate phosphoribosyltransferase (decarboxylating), quinolinate phosphoribosyltransferase 1, quinolinate phosphoribosyltransferase 2, quinolinate phosphoribosyltransferase [decarboxylating] , quinolinic acid phosphoribosyl transferase, quinolinic acid phosphoribosyltransferase, quinolinic phosphoribosyltransferase, sp.NadC, spNadC, TM1645, type II quinolic acid phosphoribosyltransferase, type II quinolinic acid phosphoribosyltransferase
ECTree
Turnover Number
Turnover Number on EC 2.4.2.19 - nicotinate-nucleotide diphosphorylase (carboxylating)
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0.14
5-phospho-alpha-D-ribose 1-diphosphate
at pH 7.2 and 37°C
0.048
nicotinic acid
-
mutant K185A, at 25°C
6
pyridine-2,3-dicarboxylate
37°C, pH 7.5
0.00024 - 1.6
quinolinic acid
additional information
5-phospho-alpha-D-ribose 1-diphosphate
0.00024
quinolinic acid
-
mutant E214A
0.00024
quinolinic acid
-
mutant R118A, at 25°C
0.00025
quinolinic acid
-
mutant E214D
0.0016
quinolinic acid
-
mutant K185A, at 25°C
0.03
quinolinic acid
-
mutant R152A, at 25°C
0.033
quinolinic acid
-
mutant K284A
0.12
quinolinic acid
at pH 7.2 and 37°C
0.5
quinolinic acid
-
mutant E214Q
1
quinolinic acid
-
wild-type
1
quinolinic acid
-
mutant H188A, at 25°C
1
quinolinic acid
-
wild-type, at 25°C
1.6
quinolinic acid
-
mutant D235A
additional information
5-phospho-alpha-D-ribose 1-diphosphate
Vmax = 0.93(+/-0.03) microM/min, wild-type, 0.3 mM quinolinic acid, UV-based assay measuring nicotinic acid mononucleotide formation at 266 nm, Vmax increases with increasing 5-phospho-alpha-D-ribose 1-diphosphate concentrations up to 5 mM
additional information
5-phospho-alpha-D-ribose 1-diphosphate
-
Vmax = 0.93(+/-0.03) microM/min, wild-type, 0.3 mM quinolinic acid, UV-based assay measuring nicotinic acid mononucleotide formation at 266 nm, Vmax increases with increasing 5-phospho-alpha-D-ribose 1-diphosphate concentrations up to 5 mM
additional information
additional information
-
-
-
additional information
additional information
-
turnover rate is decreased by adding glycerol
-
additional information
quinolinic acid
Vmax = 0.71(+/-0.0) microM/min, mutant R161A, 0.1 mM 5-phospho-alpha-D-ribose 1-diphosphate, UV-based assay measuring nicotinic acid mononucleotide formation at 266 nm
additional information
quinolinic acid
-
Vmax = 0.71(+/-0.0) microM/min, mutant R161A, 0.1 mM 5-phospho-alpha-D-ribose 1-diphosphate, UV-based assay measuring nicotinic acid mononucleotide formation at 266 nm
additional information
quinolinic acid
Vmax = 1.19(+/-0.05) microM/min, wild-type, 0.1 mM 5-phospho-alpha-D-ribose 1-diphosphate, UV-based assay measuring nicotinic acid mononucleotide formation at 266 nm
additional information
quinolinic acid
-
Vmax = 1.19(+/-0.05) microM/min, wild-type, 0.1 mM 5-phospho-alpha-D-ribose 1-diphosphate, UV-based assay measuring nicotinic acid mononucleotide formation at 266 nm