2.4.2.26: protein xylosyltransferase
This is an abbreviated version!
For detailed information about protein xylosyltransferase, go to the full flat file.
Word Map on EC 2.4.2.26
-
2.4.2.26
-
proteoglycans
-
glycosaminoglycans
-
chondroitin
-
heparan
-
xylosylation
-
chain-initiating
-
xylts
-
medicine
-
bikunin
-
laxity
-
desbuquois
-
elasticum
-
pseudoxanthoma
-
diagnostics
-
analysis
- 2.4.2.26
- proteoglycans
- glycosaminoglycans
- chondroitin
- heparan
-
xylosylation
-
chain-initiating
-
xylts
- medicine
- bikunin
-
laxity
-
desbuquois
- elasticum
-
pseudoxanthoma
- diagnostics
- analysis
Reaction
Synonyms
LARGE, More, peptide O-xylosyltransferase, peptide O-xylosyltransferase 1, peptide-O-xylosyltransferase, Rumi, squashed vulva protein 6, SQV-6, UDP-alpha-D-xyloase:proteoglycan core protein beta-D-xylosyltransferase, UDP-alpha-D-xylose:proteoglycan core protein beta-D-xylosyltransferase, UDP-D-xylose:core protein beta-D-xylosyltransferase, UDP-D-xylose:core protein xylosyltransferase, UDP-D-xylose:proteoglycan core protein b-d-xylosyltransferase, UDP-D-xylose:proteoglycan core protein beta-D-xylosyltransferase, UDP-xylose-core protein beta-D-xylosyltransferase, uridine diphosphoxylose-core protein beta-xylosyltransferase, uridine diphosphoxylose-protein xylosyltransferase, XT, XT-I, XT-II, xylosyltransferase, xylosyltransferase 1, xylosyltransferase 2, xylosyltransferase I, xylosyltransferase II, xylosyltransferase sqv-6, xylosyltransferase, uridine diphosphoxylose-core protein beta-, xylosyltransferase-I, xylosyltransferases II, XylT-I, XylT-II, XYLT1, XYLT2
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Reference on EC 2.4.2.26 - protein xylosyltransferase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Stoolmiller, A.C.; Horwitz, A.L.; Dorfman, A.
Biosynthesis of the chondroitin sulfate proteoglycan. Purification and properties of xylosyltransferase
J. Biol. Chem.
247
3525-3532
1972
Gallus gallus
Schwartz, N.B.; Roden, L.
Biosynthesis of chondroitin sulfate. Purification of UDP-D-xylose:core protein beta-D-xylosyltransferase by affinity chromatography
Carbohydr. Res.
37
167-180
1974
Gallus gallus
Campbell, P.; Jacobsson, I.; Benzing-Purdie, L.; Roden, L.; Fessler, J.H.
Silk--a new substrate for UDP-d-xylose:proteoglycan core protein beta-D-xylosyltransferase
Anal. Biochem.
137
505-516
1984
Gallus gallus
Sandy, J.D.
The assay of xylosyltransferase in cartilage extracts. A modified procedure for preparation of Smith-degraded proteoglycan
Biochem. J.
177
569-574
1979
Gallus gallus
Kearns, A.E.; Campbell, S.C.; Westley, J.; Schwartz, N.B.
Initiation of chondroitin sulfate biosynthesis: a kinetic analysis of UDP-D-xylose: core protein beta-D-xylosyltransferase
Biochemistry
30
7477-7483
1991
Rattus norvegicus
Brinkmann, T.; Weilke, C.; Kleesiek, K.
Recognition of acceptor proteins by UDP-D-xylose proteoglycan core protein beta-D-xylosyltransferase
J. Biol. Chem.
272
11171-11175
1997
Homo sapiens
Götting, C.; Kuhn, J.; Brinkmann, T.; Kleesiek, K.
Xylosylation of alternatively spliced isoforms of Alzheimer APP by xylosyltransferase
J. Protein Chem.
17
295-302
1998
Homo sapiens, Rattus norvegicus, Rattus norvegicus Lewis1WR1
Pfeil, U.; Wenzel, K.W.
Purification and some properties of UDP-xylosyltransferase of rat ear cartilage
Glycobiology
10
803-807
2000
Rattus norvegicus
Kuhn, J.; Götting, C.; Schnolzer, M.; Kempf, T.; Brinkmann, T.; Kleesiek, K.
First isolation of human UDP-D-xylose:proteoglycan core protein beta-D-xylosyltransferase secreted from cultured JAR choriocarcinoma cells
J. Biol. Chem.
276
4940-4947
2001
Homo sapiens
Götting, C.; Kuhn, J.; Zahn, R.; Brinkmann, T.; Kleesiek, K.
Molecular cloning and expression of human UDP-D-xylose:proteoglycan core protein beta-D-xylosyltransferase and its first isoform XT-II
J. Mol. Biol.
304
517-528
2000
Homo sapiens, Rattus norvegicus
Götting, C.; Kuhn, J.; Brinkmann, T.; Kleesiek, K.
Xylosyltransferase activity in seminal plasma of infertile men
Clin. Chim. Acta
317
199-202
2002
Homo sapiens
Götting, C.; Kuhn, J.; Tinneberg, H.R.; Brinkmann, T.; Kleesiek, K.
High xylosyltransferase activities in human follicular fluid and cultured granulosa-lutein cells
Mol. Hum. Reprod.
8
1079-1086
2002
Homo sapiens
Meezan, E.; Manzella, S.; Roden, L.
Menage a trois: glycogenin, proteoglycan core protein xylosyltransferase and UDP-xylose
Trends Glycosci. Glycotechnol.
7
303-332
1995
Bos taurus, Gallus gallus, Homo sapiens, Mus musculus, Rattus norvegicus
-
Schwartz, N.B.; Dorfmann, A.
Purification of rat chondrosarcoma xylosyltransferase
Arch. Biochem. Biophys.
171
136-144
1975
Rattus norvegicus
Kuhn, J.; Muller, S.; Schnolzer, M.; Kempf, T.; Schon, S.; Brinkmann, T.; Schottler, M.; Gotting, C.; Kleesiek, K.
High-level expression and purification of human xylosyltransferase I in High Five insect cells as biochemically active form
Biochem. Biophys. Res. Commun.
312
537-544
2003
Homo sapiens
Kuhn, J.; Schnolzer, M.; Schon, S.; Muller, S.; Prante, C.; Gotting, C.; Kleesiek, K.
Xylosyltransferase I acceptor properties of fibroblast growth factor and its fragment bFGF (1-24)
Biochem. Biophys. Res. Commun.
333
156-166
2005
Homo sapiens
Müller, S.; Schöttler, M.; Schön, S.; Prante, C.; Brinkmann, T.; Kuhn, J.; Götting, C.; Kleesiek, K.
Human xylosyltransferase I: functional and biochemical characterization of cysteine residues required for enzymic activity
Biochem. J.
386
227-236
2005
Homo sapiens (Q86Y38)
Bencurova, M.; Rendic, D.; Fabini, G.; Kopecky, E.M.; Altmann, F.; Wilson, I.B.H.
Expression of eukaryotic glycosyltransferases in the yeast Pichia pastoris
Biochimie
85
413-422
2003
Drosophila melanogaster
Wilson, I.B.
The never-ending story of peptide O-xylosyltransferase
Cell. Mol. Life Sci.
61
794-809
2004
Rattus norvegicus
Weilke, C.; Brinkmann, T.; Kleesiek, K.
Determination of xylosyltransferase activity in serum with recombinant human bikunin aceptor
Clin. Chem.
43
45-51
1997
Gallus gallus
Roden, L.; Körner, T.; Olson, C.; Schwartz, N.B.
Mechanisms of chain initiation in the biosynthesis of connective tissue polysaccharides
Fed. Proc.
44
373-380
1985
Gallus gallus
Baker, J.R.; Roden, L.; Stoolmiller, A.C.
Biosynthesis of chondoitin sulphate proteoglycan. Xylosyl transfer to Smith-degraded cartilage proteolycan and other exogenous acceptors
J. Biol. Chem.
247
3838-3847
1972
Gallus gallus
Wilson, I.B.H.
Functional characterisation of Drosophila melanogaster peptide O-xylosyltransferase, the key enzyme for proteolycan chain initiation and member of the core 2/I N-acetylglucosaminyltransferase family
J. BIol. Chem.
277
21207-21212
2002
Drosophila sp. (in: flies)
Götting, C.; Müller, S.; Schöttler, M.; Schön, S.; Prante, C.; Brinkmann, T.; Kuhn, J.; Kleesiek, K.
Analysis of the DXD motifs in human xylosyltransferase I required for enzyme activity
J. Biol. Chem.
279
42566-42573
2004
Homo sapiens (Q86Y38)
Bourdon, M.A.; Krusius, T.; Campbell, S.; Schwartz, N.B.; Ruoslathi, E.
Identification and synthesis of a recognition signal for the attachment of glycosaminoglycans to proteins
Proc. Natl. Acad. Sci. USA
84
3194-3198
1987
Rattus norvegicus
Mueller, S.; Disse, J.; Schoettler, M.; Schoen, S.; Prante, C.; Brinkmann, T.; Kuhn, J.; Kleesiek, K.; Goetting, C.
Human xylosyltransferase I and N-terminal truncated forms: functional characterization of the core enzyme
Biochem. J.
394
163-171
2006
Homo sapiens
Goetting, C.; Kuhn, J.; Kleesiek, K.
Human xylosyltransferases in health and disease
Cell. Mol. Life Sci.
64
1498-1517
2007
Homo sapiens (Q86Y38), Homo sapiens (Q9H1B5), Homo sapiens
Kuhn, J.; Prante, C.; Schoen, S.; Goetting, C.; Kleesiek, K.
Measurement of fibrosis marker xylosyltransferase I activity by HPLC electrospray ionization tandem mass spectrometry
Clin. Chem.
52
2243-2249
2006
Homo sapiens (Q86Y38)
Brunner, A.; Kolarich, D.; Voglmeir, J.; Paschinger, K.; Wilson, I.B.
Comparative characterisation of recombinant invertebrate and vertebrate peptide O-xylosyltransferases
Glycoconj. J.
23
543-554
2006
Drosophila melanogaster, Homo sapiens (Q86Y38), Homo sapiens, Caenorhabditis elegans (Q965Q8), Caenorhabditis elegans
Schoen, S.; Prante, C.; Bahr, C.; Kuhn, J.; Kleesiek, K.; Goetting, C.
Cloning and recombinant expression of active full-length xylosyltransferase I (XT-I) and characterization of subcellular localization of XT-I and XT-II
J. Biol. Chem.
281
14224-14231
2006
Homo sapiens (Q86Y38), Homo sapiens (Q9H1B5), Homo sapiens
Poenighaus, C.; Ambrosius, M.; Casanova, J.C.; Prante, C.; Kuhn, J.; Esko, J.D.; Kleesiek, K.; Goetting, C.
Human xylosyltransferase II is involved in the biosynthesis of the uniform tetrasaccharide linkage region in chondroitin sulfate and heparan sulfate proteoglycans
J. Biol. Chem.
282
5201-5206
2007
Homo sapiens, Homo sapiens (Q9H1B5)
Voglmeir, J.; Voglauer, R.; Wilson, I.B.
XT-II, the second isoform of human peptide-O-xylosyltransferase, displays enzymatic activity
J. Biol. Chem.
282
5984-5990
2007
Homo sapiens (Q86Y38), Homo sapiens (Q9H1B5), Homo sapiens
Goetting, C.; Hendig, D.; Adam, A.; Schoen, S.; Schulz, V.; Szliska, C.; Kuhn, J.; Kleesiek, K.
Elevated xylosyltransferase I activities in Pseudoxanthoma elasticum (PXE) patients as a marker of stimulated proteoglycan biosynthesis
J. Mol. Med.
83
984-992
2005
Homo sapiens (Q86Y38), Homo sapiens
Casanova, J.C.; Kuhn, J.; Kleesiek, K.; Goetting, C.
Heterologous expression and biochemical characterization of soluble human xylosyltransferase II
Biochem. Biophys. Res. Commun.
365
678-684
2008
Homo sapiens (Q9H1B5), Homo sapiens
Prante, C.; Milting, H.; Kassner, A.; Farr, M.; Ambrosius, M.; Schoen, S.; Seidler, D.G.; Banayosy, A.E.; Koerfer, R.; Kuhn, J.; Kleesiek, K.; Goetting, C.
Transforming growth factor beta1-regulated xylosyltransferase I activity in human cardiac fibroblasts and its impact for myocardial remodeling
J. Biol. Chem.
282
26441-26449
2007
Homo sapiens (Q86Y38), Homo sapiens (Q9H1B5), Homo sapiens
Casanova, J.C.; Roch, C.; Kuhn, J.; Kleesiek, K.; Goetting, C.
First in-gel detection and purification of human xylosyltransferase II
Biochem. Biophys. Res. Commun.
379
243-248
2009
Homo sapiens
Casanova, J.C.; Ambrosius, M.; Kuhn, J.; Kleesiek, K.; Goetting, C.
Analysis of xylosyltransferase II binding to the anticoagulant heparin
Biochem. Biophys. Res. Commun.
383
4-10
2009
Homo sapiens
Roch, C.; Kuhn, J.; Kleesiek, K.; Goetting, C.
Differences in gene expression of human xylosyltransferases and determination of acceptor specificities for various proteoglycans
Biochem. Biophys. Res. Commun.
391
685-691
2010
Homo sapiens
Ambrosius, M.; Kleesiek, K.; Goetting, C.
The xylosyltransferase I gene polymorphism c.343G-T (p.A115S) is associated with decreased serum glycosaminoglycan levels
Clin. Biochem.
42
1-4
2009
Homo sapiens
Condac, E.; Dale, G.L.; Bender-Neal, D.; Ferencz, B.; Towner, R.; Hinsdale, M.E.
Xylosyltransferase II is a significant contributor of circulating xylosyltransferase levels and platelets constitute an important source of xylosyltransferase in serum
Glycobiology
19
829-833
2009
Homo sapiens, Mus musculus
Mueller, B.; Prante, C.; Kleesiek, K.; Goetting, C.
Identification and characterization of the human xylosyltransferase I gene promoter region
J. Biol. Chem.
284
30775-30782
2009
Homo sapiens
Venkatesan, N.; Barre, L.; Bourhim, M.; Magdalou, J.; Mainard, D.; Netter, P.; Fournel-Gigleux, S.; Ouzzine, M.
Xylosyltransferase-I regulates glycosaminoglycan synthesis during the pathogenic process of human osteoarthritis
PLoS ONE
7
e34020
2012
Homo sapiens (Q86Y38)
Takeuchi, H.; Fernandez-Valdivia, R.C.; Caswell, D.S.; Nita-Lazar, A.; Rana, N.A.; Garner, T.P.; Weldeghiorghis, T.K.; Macnaughtan, M.A.; Jafar-Nejad, H.; Haltiwanger, R.S.
Rumi functions as both a protein O-glucosyltransferase and a protein O-xylosyltransferase
Proc. Natl. Acad. Sci. USA
108
16600-16605
2011
Homo sapiens, Mus musculus
Takeuchi, H.; Haltiwanger, R.S.
Enzymatic analysis of the protein O-glycosyltransferase, Rumi, acting toward epidermal growth factor-like (EGF) repeats
Methods Mol. Biol.
1022
119-128
2013
Drosophila melanogaster
Haltom, A.R.; Lee, T.V.; Harvey, B.M.; Leonardi, J.; Chen, Y.J.; Hong, Y.; Haltiwanger, R.S.; Jafar-Nejad, H.
The protein O-glucosyltransferase Rumi modifies eyes shut to promote rhabdomere separation in Drosophila
PLoS Genet.
10
e1004795
2014
Drosophila melanogaster
de la Morena-Barrio, M.; Buil, A.; Anton, A.; Martinez-Martinez, I.; Minano, A.; Gutierrez-Gallego, R.; Navarro-Fernandez, J.; Aguila, S.; Souto, J.; Vicente, V.; Soria, J.; Corral, J.
Identification of antithrombin-modulating genes. Role of LARGE, a gene encoding a bifunctional glycosyltransferase, in the secretion of proteins?
PLoS ONE
8
e64998
2013
Homo sapiens
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