2.4.2.28: S-methyl-5'-thioadenosine phosphorylase

This is an abbreviated version!
For detailed information about S-methyl-5'-thioadenosine phosphorylase, go to the full flat file.

Reaction

Synonyms

5'-deoxy-5'-methylthioadenosine phosphorylase, 5'-deoxy-5'-methylthioadenosine phosphorylase II, 5'-deoxy-5'-methylthioadenosine:orthophosphate methylthioribosyltransferase, 5'-methylthioadenosine nucleosidase, 5'-methylthioadenosine phosphorylase, 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, 5-methylthioadenosine phosphorylase, 5�-methylthioadenosine phosphorylase, MeSAdo phosphorylase, MeSAdo/Ado phosphorylase, methylthioadenosine nucleosidase, methylthioadenosine nucleoside phosphorylase, methylthioadenosine phosphorylase, MTA phosphorylase, MTAN, MTAN1, MTAN2, MTAP, Mtap protein, MTAPase, MTN1, MTN2, PfMTAP, phosphorylase, methylthioadenosine, RSFP, Rv0535, SsMTAP, SsMTAP II, SsMTAPII, SSO2343

ECTree

     2 Transferases

         2.4 Glycosyltransferases

             2.4.2 Pentosyltransferases

                2.4.2.28 S-methyl-5'-thioadenosine phosphorylase

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Results	in table
12	Activating Compound
9873	AA Sequence
10	Application
1	CAS Registry Number
33	Cloned(Commentary)
15	Crystallization (Commentary)
738	Disease/ Diagnostics
3	Expression
13	General Information
13	General Stability
10	IC50 Value
146	Inhibitors
38	kcat/KM [mM/s]
68	Ki Value [mM]
119	KM Value [mM]
7	Localization
3	Metals/Ions
35	Molecular Weight [Da]
44	Natural Substrates/ Products (Substrates)
19	Organic Solvent Stability
267	Organism
1	Oxidation Stability
6	Pathway
177	PDB ID
22	pH Optimum
5	pH Range
1	pH Stability
2	pI Value
53	Protein Variants
39	Purification (Commentary)
16	Reaction
1	Reaction Type
92	Reference
1	Renatured (Commentary)
116	Source Tissue
49	Specific Activity [micromol/min/mg]
8	Storage Stability
229	Substrates and Products (Substrate)
40	Subunits
130	Synonyms
1	Systematic Name
36	Temperature Optimum [°C]
10	Temperature Range [°C]
54	Temperature Stability [°C]
77	Turnover Number [1/s]

KCat KM Value

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KCat KM Value on EC 2.4.2.28 - S-methyl-5'-thioadenosine phosphorylase

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kcat/KM VALUE [1/mMs^-1]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

200

2'-chloro-2'-deoxyadenosine

Trypanosoma brucei

-

at pH 7.4 and 37°C

736501

26.5 - 95.83

2'-deoxyadenosine

6 entries

1080

2'-fluoro-2'-deoxyadenosine

Trypanosoma brucei

-

at pH 7.4 and 37°C

736501

81.37 - 196.32

5'-deoxy-5'-methylthioadenosine

6 entries

588 - 2600

5'-methylthioadenosine

2 entries

18.97 - 650

adenosine

7 entries

1160

deoxyadenosine

Trypanosoma brucei

-

at pH 7.4 and 37°C

736501

15 - 24000

S-methyl-5'-thioadenosine

14 entries

26.5

2'-deoxyadenosine

Schistosoma mansoni

I0B503

mutant enzyme Q289L, at pH 7.4 and 25°C

760012

42.71

2'-deoxyadenosine

Schistosoma mansoni

I0B503

mutant enzyme N87T, at pH 7.4 and 25°C

760012

45.88

2'-deoxyadenosine

Schistosoma mansoni

I0B503

mutant enzyme S12T/N87T/Q289L, at pH 7.4 and 25°C

760012

48.92

2'-deoxyadenosine

Schistosoma mansoni

I0B503

mutant enzyme S12T, at pH 7.4 and 25°C

760012

56.49

2'-deoxyadenosine

Schistosoma mansoni

I0B503

wild type enzyme, at pH 7.4 and 25°C

760012

95.83

2'-deoxyadenosine

Schistosoma mansoni

I0B503

mutant enzyme S12T/N87T, at pH 7.4 and 25°C

760012

81.37

5'-deoxy-5'-methylthioadenosine

Schistosoma mansoni

I0B503

mutant enzyme S12T/N87T/Q289L, at pH 7.4 and 25°C

760012

97.02

5'-deoxy-5'-methylthioadenosine

Schistosoma mansoni

I0B503

mutant enzyme Q289L, at pH 7.4 and 25°C

760012

118.93

5'-deoxy-5'-methylthioadenosine

Schistosoma mansoni

I0B503

mutant enzyme S12T, at pH 7.4 and 25°C

760012

119.18

5'-deoxy-5'-methylthioadenosine

Schistosoma mansoni

I0B503

mutant enzyme N87T, at pH 7.4 and 25°C

760012

122.25

5'-deoxy-5'-methylthioadenosine

Schistosoma mansoni

I0B503

wild type enzyme, at pH 7.4 and 25°C

760012

196.32

5'-deoxy-5'-methylthioadenosine

Schistosoma mansoni

I0B503

mutant enzyme S12T/N87T, at pH 7.4 and 25°C

760012

588

5'-methylthioadenosine

Arabidopsis thaliana

Q7XA67, Q9T0I8

-

681477

2600

5'-methylthioadenosine

Arabidopsis thaliana

Q7XA67, Q9T0I8

-

681477

18.97

adenosine

Schistosoma mansoni

I0B503

mutant enzyme N87T, at pH 7.4 and 25°C

760012

38.13

adenosine

Schistosoma mansoni

I0B503

mutant enzyme S12T/N87T/Q289L, at pH 7.4 and 25°C

760012

46.86

adenosine

Schistosoma mansoni

I0B503

mutant enzyme S12T, at pH 7.4 and 25°C

760012

54.58

adenosine

Schistosoma mansoni

I0B503

mutant enzyme Q289L, at pH 7.4 and 25°C

760012

83.94

adenosine

Schistosoma mansoni

I0B503

mutant enzyme S12T/N87T, at pH 7.4 and 25°C

760012

106.4

adenosine

Schistosoma mansoni

I0B503

wild type enzyme, at pH 7.4 and 25°C

760012

650

adenosine

Trypanosoma brucei

-

at pH 7.4 and 37°C

736501

15

S-methyl-5'-thioadenosine

Brucella melitensis

Q8YBL1

mutant enzyme M144A, at pH 7.0 and 25°C

726889

24

S-methyl-5'-thioadenosine

Brucella melitensis

Q8YBL1

mutant enzyme Y134F, at pH 7.0 and 25°C

726889

28

S-methyl-5'-thioadenosine

Brucella melitensis

Q8YBL1

mutant enzyme Y134A, at pH 7.0 and 25°C

726889

79

S-methyl-5'-thioadenosine

Brucella melitensis

Q8YBL1

mutant enzyme W179F, at pH 7.0 and 25°C

726889

130

S-methyl-5'-thioadenosine

Brucella melitensis

Q8YBL1

mutant enzyme S167A, at pH 7.0 and 25°C

726889

130

S-methyl-5'-thioadenosine

Brucella melitensis

Q8YBL1

mutant enzyme W179A, at pH 7.0 and 25°C

726889

250

S-methyl-5'-thioadenosine

Brucella melitensis

Q8YBL1

mutant enzyme R85A, at pH 7.0 and 25°C

726889

280

S-methyl-5'-thioadenosine

Brucella melitensis

Q8YBL1

mutant enzyme R85H, at pH 7.0 and 25°C

726889

510

S-methyl-5'-thioadenosine

Brucella melitensis

Q8YBL1

mutant enzyme V34A, at pH 7.0 and 25°C

726889

560

S-methyl-5'-thioadenosine

Brucella melitensis

Q8YBL1

mutant enzyme V34I, at pH 7.0 and 25°C

726889

580

S-methyl-5'-thioadenosine

Brucella melitensis

Q8YBL1

mutant enzyme A15M, at pH 7.0 and 25°C

726889

600

S-methyl-5'-thioadenosine

Brucella melitensis

Q8YBL1

mutant enzyme R164A, at pH 7.0 and 25°C

726889

4000

S-methyl-5'-thioadenosine

Brucella melitensis

Q8YBL1

wild type enzyme, at pH 7.0 and 25°C

726889

24000

S-methyl-5'-thioadenosine

Trypanosoma brucei

-

at pH 7.4 and 37°C

736501