2.4.2.3: uridine phosphorylase

This is an abbreviated version!
For detailed information about uridine phosphorylase, go to the full flat file.

Reaction

Synonyms

apUP, EC 2.4.2.23, L-UrdPase, More, PcUP1, PcUP2, phosphorylase, uridine, pynpase, pyrimidine nucleoside phosphorylase, pyrimidine phosphorylase, pyrimidine/purine nucleoside phosphorylase, StUPh, udp, UDRPase , UP type 1, UP1, UP2, uPA, UPase, UPase-2, UPb, UPH, UPP1, UPP2, UrdPase, uridine phosphorylase, uridine phosphorylase 1, uridine phosphorylase-1, uridine phosphorylase-2, uridine:orthophosphate alpha-D-ribosyltransferase, VchUPh

ECTree

     2 Transferases

         2.4 Glycosyltransferases

             2.4.2 Pentosyltransferases

                2.4.2.3 uridine phosphorylase

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Results	in table
5	Activating Compound
5766	AA Sequence
9	Application
1	CAS Registry Number
32	Cloned(Commentary)
31	Crystallization (Commentary)
354	Disease/ Diagnostics
7	Expression
19	General Information
4	General Stability
127	Inhibitors
8	kcat/KM [mM/s]
39	Ki Value [mM]
85	KM Value [mM]
10	Localization
2	Metals/Ions
29	Molecular Weight [Da]
41	Natural Substrates/ Products (Substrates)
667	Organism
8	Pathway
483	PDB ID
23	pH Optimum
7	pH Range
1	pH Stability
78	Protein Variants
46	Purification (Commentary)
18	Reaction
3	Reaction Type
127	Reference
1	Renatured (Commentary)
86	Source Tissue
20	Specific Activity [micromol/min/mg]
6	Storage Stability
200	Substrates and Products (Substrate)
35	Subunits
81	Synonyms
1	Systematic Name
12	Temperature Optimum [°C]
1	Temperature Range [°C]
8	Temperature Stability [°C]
6	Turnover Number [1/s]

KI Value

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KI Value on EC 2.4.2.3 - uridine phosphorylase

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Ki VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.027

1-((2-pyrrolidine-1-yl)ethyl)uracil

Plasmodium falciparum

Q8I3X4

pH 7.5, 25°C

722185

0.0027

1-(1',3'-dihydroxy-2'-propoxy)methyl-5,6-tetramethyleneuracil

Escherichia coli

-

-

638522

0.00007

1-(1',3'-dihydroxy-2'-propoxy)methyl-5-benzyluracil

Hymenolepis diminuta

-

-

638535

0.109

2',3'-Dideoxy-5-ethyluridine

Rattus norvegicus

-

-

638458

1.003

2'-deoxylyxofuranosyl-5-ethyluracil

Rattus norvegicus

-

-

638458

0.000025 - 0.00007

2,2'-Anhydro-5-ethyluridine

2 entries

0.014

2,3'-anhydro-5-ethyluridine

Hymenolepis diminuta

-

-

638535

0.005

2-deoxyglycosylthymine

Homo sapiens

-

-

638510

0.225

3'-Azido-2',3'-dideoxy-5-ethyluridine

Rattus norvegicus

-

-

638458

0.056

3'-Azido-2',3'-dideoxy-5-methyluridine

Rattus norvegicus

-

-

638458

0.448

3'-Bromo-2',3'-dideoxy-5-ethyluridine

Rattus norvegicus

-

-

638458

0.21

3'-Chloro-2',3'-dideoxy-5-ethyluridine

Rattus norvegicus

-

-

638458

0.361

3'-Chloro-2',3'-dideoxy-5-methyluridine

Rattus norvegicus

-

-

638458

0.006

3-((2-pyrrolidine-1-yl)ethyl)uracil

Plasmodium falciparum

Q8I3X4

pH 7.5, 25°C

722185

1.36

3-O-methyl-alpha-D-glucopyranose

Lacticaseibacillus casei

-

-

638455

0.000018

5-(3'-Benzyloxybenzyl)-1-[(1'-aminomethyl-2'-hydroxyethoxy)methyl]uracil

Mus musculus

-

-

638513

0.000098 - 0.0073

5-benzylacyclouridine

3 entries

0.013

5-bromoacyclouridine

Homo sapiens

-

-

638510

0.014

5-fluoroacyclouridine

Homo sapiens

-

-

638510

0.03

5-iodoacyclouridine

Homo sapiens

-

-

638510

0.00068

5-m-benzyloxybenzyl acyclouridine

Escherichia coli

P12758

-

657472

0.003

Acyclothymidine

Homo sapiens

-

-

638510

0.015

acyclouridine

Homo sapiens

-

-

638510

0.034 - 3.5

alpha-D-ribose 1-phosphate

3 entries

0.107

Arabinofuranosyl-5-ethyluracil

Rattus norvegicus

-

-

638458

0.07 - 2.5

N-ethyl-5-phenylisoxazolium-3'-sulfonate

3 entries

0.0088

tetramethylene acyclouridine

Hymenolepis diminuta

-

-

638535

0.05 - 1.45

Uracil

3 entries

0.047

uridine

Hymenolepis diminuta

-

-

638535

additional information

additional information

Schistosoma mansoni

-

-

638531

-

0.000025

2,2'-Anhydro-5-ethyluridine

Homo sapiens

-

-

638512

0.00007

2,2'-Anhydro-5-ethyluridine

Hymenolepis diminuta

-

-

638535

0.000098

5-benzylacyclouridine

Homo sapiens

-

in 50 mM Tris, 1 mM EDTA, pH 7.4, at 37°C

674032

0.0043

5-benzylacyclouridine

Escherichia coli

P12758

-

657472

0.0073

5-benzylacyclouridine

Homo sapiens

-

-

638461

0.034

alpha-D-ribose 1-phosphate

Homo sapiens

Q16831

pH 7.4, 37°C, versus uridine

701939

0.494

alpha-D-ribose 1-phosphate

Homo sapiens

Q16831

pH 7.4, 37°C, versus phosphate

701939

3.5

alpha-D-ribose 1-phosphate

Lacticaseibacillus casei

-

-

638455

0.07

N-ethyl-5-phenylisoxazolium-3'-sulfonate

Escherichia coli

-

-

638537

2.1

N-ethyl-5-phenylisoxazolium-3'-sulfonate

Escherichia coli

-

addition of uridine

638537

2.5

N-ethyl-5-phenylisoxazolium-3'-sulfonate

Escherichia coli

-

addition of uracil

638537

0.05

Uracil

Homo sapiens

Q16831

pH 7.4, 37°C, versus uridine

701939

0.137

Uracil

Homo sapiens

Q16831

pH 7.4, 37°C, versus phosphate

701939

1.45

Uracil

Lacticaseibacillus casei

-

-

638455