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2.4.2.31: NAD+-protein-arginine ADP-ribosyltransferase

This is an abbreviated version!
For detailed information about NAD+-protein-arginine ADP-ribosyltransferase, go to the full flat file.

Word Map on EC 2.4.2.31

Reaction

NAD+
+
L-arginine
=
nicotinamide
 +
Nomega-(ADP-D-ribosyl)-L-arginine
 +
H+

Synonyms

(adenosine diphosphoribose)transferase, nicotinamide adenine dinucleotide-arginine, actin-specific ADP-ribosyltransferase, ADP-ribosyl-acceptor hydrolase 1, ADP-ribosyltransferase, ADP-ribosyltransferase enzymatic component, ADP-ribosyltransferase-2, ADPRT, alloantigen Rt6.1 , alloantigen Rt6.2 , ALT, arginine ADP-ribosyltransferase 1, arginine specific ADP-ribosyltransferase, arginine specific mono-ADP-ribosyltransferase, arginine-specific adenosine diphosphate ribosyltransferase 1, arginine-specific ADP-ribosyltransferase, arginine-specific ADP-ribosyltransferase 1, arginine-specific ADP-ribosytransferases 1, arginine-specific mono-ADP-ribosyltransferase, arginine-specific mono-ADP-ribosyltransferase 1, arginine-specific mono-ADP-ribosyltransferase A, ARH1, ART, ART1, ART2, ART3, ART4, ART5, Art7.1, Art7.2, ARTase, ARTC1, ARTD15, ARTD15/PARP16, asparagine-specific ADP-ribosyltransferase, AT1 , AT2 , binary toxin, binary toxin A, binary toxin component Ia, C2 toxin, C2I, cARTC2.1, CD196 ADP-ribosyltransferase, CDT, CdtA, cholera toxin, cholix toxin, CTA, Dombrock blood group carrier molecule , exoenzyme C3, glycosylphosphatidylinositol-anchored arginine-specific ADP-ribosyltransferase7.1, i-toxin, iota toxin, MART-A, mono(ADP-ribosyl)transferase , mono-ADP-ribosyl-arginine hydrolase, mono-ADP-ribosyltransferase, mono-ADP-ribosyltransferase A, NAD(P)+-arginine ADP-ribosyltransferase, NAD+:arginine ADP-ribosyltransferase, NAD+:arginine ecto-mono(ADP-ribosyl)transferase, NAD+:L-arginine ADP-D-ribosyltransferase, NAD-arginine ADP-ribosyltransferase, NAD-arginine mono-ADP-ribosyltransferase B, NAD-dependent ADPribosyltransferase, NAD:arginine ADP-ribosyltransferase, NAD:arginine ADP-ribosyltransferase B, NarE, PARP16/ARTD15, RT6, RT6.1, RT6.2, T-cell surface protein Rt6.1 , T-cell surface protein Rt6.2 , TcdB2-TccC3, VIP2, Vis toxin, XAC3230, XopAI

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.2 Pentosyltransferases
                2.4.2.31 NAD+-protein-arginine ADP-ribosyltransferase

Substrates Products

Substrates Products on EC 2.4.2.31 - NAD+-protein-arginine ADP-ribosyltransferase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
A1 peptide of cholera toxin + NAD+
nicotinamide + ?
show the reaction diagram
-
four mol of ADP-ribose are incorporated into 1 mol of A1 peptide. Modification of the A1 peptide increases its enzymatic activity up to 4fold
-
-
?
actin + NAD+
?
show the reaction diagram
-
-
-
-
?
actin + NAD+
nicotinamide + ?
show the reaction diagram
agmatine + NAD+
nicotinamide + ?
show the reaction diagram
arginine + NAD+
nicotinamide + ADP-ribose-L-arginine
show the reaction diagram
-
-
-
-
?
basic fibroblast growth factor FGF-2 + NAD+
nicotinamide + ?
show the reaction diagram
beta-lactoglobulin + NAD+
nicotinamide + ?
show the reaction diagram
-
-
-
-
?
bovine plasma albumin + NAD+
nicotinamide + ?
show the reaction diagram
-
-
-
-
?
bovine serum albumin + NAD+
nicotinamide + ?
show the reaction diagram
-
poor ADP-ribose acceptor
-
-
?
casein + NAD+
nicotinamide + ?
show the reaction diagram
diethylamino-(benzylidineamino)guanidine + NAD+
nicotinamide + ?
show the reaction diagram
-
-
-
-
?
DNase I + NAD+
nicotinamide + ?
show the reaction diagram
-
-
-
-
?
FGF-2 + NAD+
?
show the reaction diagram
guanidine + NAD+
nicotinamide + ?
show the reaction diagram
-
-
-
-
?
guanidinobutyrate + NAD+
nicotinamide + ?
show the reaction diagram
-
-
-
-
?
guanidinopropionate + NAD+
nicotinamide + ?
show the reaction diagram
-
-
-
-
?
histone + NAD+
nicotinamide + ?
show the reaction diagram
histone + NAD+
Nomega-[(2'-phospho-ADP)-D-ribosyl]-histone-L-arginine + nicotinamide + H+
show the reaction diagram
-
isozyme ART2 is active with high and low molecular weight histones, membrane-bound and PI-PLC released ART2 preferentially ADP-ribosylate high or low MW histones, respectively
-
-
?
histone f1 + NAD+
nicotinamide + ?
show the reaction diagram
-
-
-
-
?
histone f2a + NAD+
nicotinamide + ?
show the reaction diagram
-
-
-
-
?
histone f2b + NAD+
nicotinamide + ?
show the reaction diagram
-
-
-
-
?
histone f3 + NAD+
nicotinamide + ?
show the reaction diagram
-
-
-
-
?
histone H2B + NAD+
Nomega-[(2'-phospho-ADP)-D-ribosyl]-histone H2B-L-arginine + nicotinamide
show the reaction diagram
Meleagris sp.
-
-
-
-
?
human alpha-defensin-1 + NAD+
nicotinamide + ?
show the reaction diagram
human alpha-globulin + NAD+
nicotinamide + ?
show the reaction diagram
-
-
-
-
?
human beta-defensin-1 + NAD+
nicotinamide + ?
show the reaction diagram
-
-
-
-
?
human beta-globulin + NAD+
nicotinamide + ?
show the reaction diagram
-
-
-
-
?
human gamma-globulin + NAD+
nicotinamide + ?
show the reaction diagram
-
-
-
-
?
human neutrophil peptide-1 + NAD+
Nomega-(ADP-D-ribosyl)-L-arginine-human neutrophil peptide-1 + nicotinamide
show the reaction diagram
karyopherin-beta1 + NAD+
nicotinamide + ?
show the reaction diagram
-
-
-
?
L-arginine methyl ester + NAD+
nicotinamide + Nomega-(ADP-D-ribosyl)-L-arginine
show the reaction diagram
L-arginine methyl ester + NADP+
nicotinamide + N2-(2'-phospho-ADP-D-ribosyl)-L-arginine
show the reaction diagram
-
-
-
-
?
lysozyme + NAD+
nicotinamide + ?
show the reaction diagram
NAD+ + (ADP-D-ribosyl)n-acceptor
nicotinamide + (ADP-D-ribosyl)n+1-acceptor
show the reaction diagram
-
agmatine as ADPribose acceptor is used
-
-
?
NAD+ + actin
nicotinamide + H+ + (ADP-ribosyl)-actin
show the reaction diagram
NAD+ + agmatine
nicotinamide + Nomega-(ADP-D-ribosyl)-agmatine
show the reaction diagram
NAD+ + alpha-actin-L-arginine
nicotinamide + Nomega-(ADP-D-ribosyl)-alpha-actin-L-arginine
show the reaction diagram
-
skeletal muscle alpha actin
-
-
?
NAD+ + beta-actin
nicotinamide + H+ + (ADP-ribosyl)-beta-actin
show the reaction diagram
-
modification occurs at residue Arg177
-
?
NAD+ + beta/gamma-actin-L-arginine
nicotinamide + Nomega-(ADP-D-ribosyl)-beta/gamma-actin-L-arginine
show the reaction diagram
-
non-muscle beta/gamma actin
-
-
?
NAD+ + eEF2 L-arginine
nicotinamide + Nomega-(ADP-D-ribosyl)-eEF2-L-arginine
show the reaction diagram
-
-
-
?
NAD+ + gamma-actin
nicotinamide + H+ + (ADP-ribosyl)-gamma-actin
show the reaction diagram
-
modification occurs at residue Arg177
-
?
NAD+ + gamma-actin-L-arginine
nicotinamide + Nomega-(ADP-D-ribosyl)-gamma-actin-L-arginine
show the reaction diagram
-
smooth muscle gamma actin
-
-
?
NAD+ + glucose-regulated protein of 78 kDa/immunoglobulin heavy-chainbinding protein L-arginine
nicotinamide + Nomega-(ADP-D-ribosyl)-glucose-regulated protein of 78 kDa/immunoglobulin heavy-chainbinding protein-L-arginine
show the reaction diagram
-
-
-
?
NAD+ + human neutrophil peptide-1
nicotinamide + Nomega-(ADP-D-ribosyl)-human neutrophil peptide-1
show the reaction diagram
NAD+ + MazF L-arginine
nicotinamide + Nomega-(ADP-D-ribosyl)-MazF-L-arginine
show the reaction diagram
Tequatrovirus T4
-
the enzyme ADP-ribosylates MazF at an arginine residue at position 4
-
-
?
NAD+ + muscle actin
nicotinamide + H+ + (ADP-ribosyl)-muscle actin
show the reaction diagram
substrate source rabbit skeletal muscle
modification occurs at residue Arg177
-
?
NAD+ + non-muscle actin from human platelets
nicotinamide + (ADP-D-ribosyl)-non-muscle actin from human platelets
show the reaction diagram
-
-
-
-
?
NAD+ + polyarginine
nicotinamide + Nomega-(ADP-D-ribosyl)-polyarginine
show the reaction diagram
-
-
-
?
NAD+ + protein L-arginine
nicotinamide + Nomega-(ADP-D-ribosyl)-protein-L-arginine
show the reaction diagram
NAD+ + protein poly-L-arginine
nicotinamide + Nomega-(ADP-D-ribosyl)-protein-poly-L-arginine
show the reaction diagram
-
-
-
?
NAD+ + protein R10H6 L-arginine
nicotinamide + Nomega-(ADP-D-ribosyl)-protein N10H6-L-arginine
show the reaction diagram
-
-
-
?
NAD+ + rabbit muscle actin
nicotinamide + (ADP-D-ribosyl)-rabbit muscle actin
show the reaction diagram
-
-
-
-
?
NAD+ + [actin]-L-arginine177
nicotinamide + [actin]-N-(ADP-D-ribosyl)-L-arginine177 + H+
show the reaction diagram
nicotinamide + Nomega-(ADP-D-ribosyl)-agmatine-L-arginine
NAD+ + agmatine L-arginine
show the reaction diagram
-
-
-
-
r
ovalbumin + NAD+
nicotinamide + ?
show the reaction diagram
p-nitrobenzylidine aminoguanidine + NAD+
nicotinamide + mono-ADP-ribosylated p-nitrobenzylidine aminoguanidine
show the reaction diagram
P2X7 purinoceptor protein + NAD+
Nomega-[(2'-phospho-ADP)-D-ribosyl]-P2X7 purinoceptor protein-L-arginine + nicotinamide
show the reaction diagram
-
isozyme ART2
-
-
?
P2X7(k) + NAD+
nicotinamide + ?
show the reaction diagram
-
the P2X7(k) variant is sensitive to activation by ADP-ribosylation whereas the P2X7(a) variant is insensitive
-
-
?
P33 + NAD+
nicotinamide + ?
show the reaction diagram
p33 protein + NAD+
nicotinamide + ?
show the reaction diagram
-
-
-
?
polyarginine + NAD+
nicotinamide + ?
show the reaction diagram
polylysine + NAD+
nicotinamide + ?
show the reaction diagram
-
poor ADP-ribose acceptor
-
-
?
Ras + NAD+
nicotinamide + ?
show the reaction diagram
-
ADP-ribosylation of Ras at Arg41 and Arg 128. The double mutant RasR141K/R128K is ribosylated at an alternative sitem Arg135
-
-
?
RhoA + NAD+
Nomega-(ADP-D-ribosyl)-L-asparagine41-RhoA + nicotinamide
show the reaction diagram
-
the enzyme modifies the low-molecular-mass GTPase RhoA specifically at Asn41
-
-
?
RhoB + NAD+
Nomega-(ADP-D-ribosyl)-L-asparagine41-RhoB + nicotinamide
show the reaction diagram
-
the enzyme modifies the low-molecular-mass GTPase RhoB specifically at Asn41
-
-
?
RhoC + NAD+
Nomega-(ADP-D-ribosyl)-L-asparagine41-RhoC + nicotinamide
show the reaction diagram
-
the enzyme modifies the low-molecular-mass GTPase RhoC specifically at Asn41
-
-
?
soy bean trypsin inhibitor + NAD+
nicotinamide + ?
show the reaction diagram
-
-
-
-
?
soybean trypsin inhibitor + NAD+
Nomega-(ADP-D-ribosyl)-L-arginine-soybean trypsin inhibitor + nicotinamide
show the reaction diagram
-
-
-
-
?
trypsin inhibitor + NAD+
nicotinamide + ?
show the reaction diagram
-
-
-
-
?
wild-type exoenzyme C3 + NAD+
Nomega-(ADP-D-ribosyl)-L-arginine86-wild-type exoenzyme C3 + nicotinamide
show the reaction diagram
-
the recombinant mutant Q217E enzyme modifies the recombinant wild-type enzyme at Arg86
-
-
?
additional information
?
-