2.4.2.4: thymidine phosphorylase

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For detailed information about thymidine phosphorylase, go to the full flat file.

Reaction

Synonyms

angiogenic factor platelet-derived endothelial cell growth factor/thymidine phosphorylase, animal growth regulators, blood platelet-derived endothelial cell growth factors, blood platelet-derived endothelial cell growth factor, deoA, deoxythymidine phosphorylase, dthdpase, EC 2.4.2.23, gliostatin, gliostatins, GLS, HTP, More, PD-ECGF, PD-ECGF/TP, PD-ECGF/TP platelet-derived endothelial cell growth factor, PDECGF, phosphorylase, thymidine, platelet derived endothelial cell growth factor, platelet derived endothelial cell grwoth factor, platelet derived-endothelial cell growth factor, platelet-derived endothelial cell growth factor, platelet-derived endothelial cell growth factor/thymidine phosphorylase, platelet-derived endotherial cell growth factor, ppnP, pynpase, pyrimidine deoxynucleoside phosphorylase, pyrimidine nucleoside phosphorylase, pyrimidine phosphorylase, pyrimidine/purine nucleoside phosphorylase, TDRPASE, ThdPase, thymidine phosphorylase, thymidine Pi deoxyribosyltransferase, thymidine-orthophosphate deoxyribosyltransferase, thymidine:orthophosphate deoxy-D-ribosyltransferase, Tpase, TYMP

ECTree

     2 Transferases

         2.4 Glycosyltransferases

             2.4.2 Pentosyltransferases

                2.4.2.4 thymidine phosphorylase

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Results	in table
31	Activating Compound
12092	AA Sequence
43	Application
1	CAS Registry Number
24	Cloned(Commentary)
14	Crystallization (Commentary)
6222	Disease/ Diagnostics
7	Expression
40	General Information
8	General Stability
366	IC50 Value
694	Inhibitors
3	kcat/KM [mM/s]
161	Ki Value [mM]
81	KM Value [mM]
17	Localization
34	Molecular Weight [Da]
82	Natural Substrates/ Products (Substrates)
366	Organism
6	Pathway
41	PDB ID
39	pH Optimum
4	pH Range
1	pH Stability
1	pI Value
2	Posttranslational Modification
27	Protein Variants
36	Purification (Commentary)
12	Reaction
2	Reaction Type
186	Reference
260	Source Tissue
40	Specific Activity [micromol/min/mg]
7	Storage Stability
289	Substrates and Products (Substrate)
30	Subunits
111	Synonyms
1	Systematic Name
18	Temperature Optimum [°C]
6	Temperature Stability [°C]
34	Turnover Number [1/s]

Expression

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Expression on EC 2.4.2.4 - thymidine phosphorylase

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EXPRESSION

ORGANISM

UNIPROT

LITERATURE

capecitabine does not affect enzyme activity and expression

Homo sapiens

-

701722

chorionic gonadotropin36 and a combination of progesterone and transforming growth factor b1 upregulate the enzyme expression. The enzyme is also upregulated in several diseases, detailed overview

Homo sapiens

-

705495

EGF receptor inhibition may lead to TP overexpression, and tissue hypoxia secondary to low hemoglobin levels may induce TP overexpression

Homo sapiens

P19971

759291

the enzyme expression is is inversely correlated with estradiol concentrations in the endometrium

Homo sapiens

-

705495

the enzyme is highly upregulated in a variety of solid tumours

Homo sapiens

P19971

759143

the enzyme is strongly induced in the serum-deprived nasopharyngeal carcinoma cell lines TW-01, TW-02, and TW-04, the serum deprivation-triggered upregulation of the enzyme is due to mRNA stabilization, not protein stabilization or transcriptional activation requiring the mRNA CU-rich element sequence and heterogeneous nuclear ribonucleoprotein K, mechanism and kinetics, overview

Homo sapiens

-

706011

treatment with 0.005-0.04 mM tamoxifen decreases mRNA and protein levels through AKT inactivation

Homo sapiens

-

735645