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2.4.2.4: thymidine phosphorylase

This is an abbreviated version!
For detailed information about thymidine phosphorylase, go to the full flat file.

Word Map on EC 2.4.2.4

Reaction

thymidine
+
phosphate
=
thymine
 +
2-deoxy-alpha-D-ribose 1-phosphate

Synonyms

angiogenic factor platelet-derived endothelial cell growth factor/thymidine phosphorylase, animal growth regulators, blood platelet-derived endothelial cell growth factors, blood platelet-derived endothelial cell growth factor, deoA, deoxythymidine phosphorylase, dthdpase, EC 2.4.2.23, gliostatin, gliostatins, GLS, HTP, More, PD-ECGF, PD-ECGF/TP, PD-ECGF/TP platelet-derived endothelial cell growth factor, PDECGF, phosphorylase, thymidine, platelet derived endothelial cell growth factor, platelet derived endothelial cell grwoth factor, platelet derived-endothelial cell growth factor, platelet-derived endothelial cell growth factor, platelet-derived endothelial cell growth factor/thymidine phosphorylase, platelet-derived endotherial cell growth factor, ppnP, pynpase, pyrimidine deoxynucleoside phosphorylase, pyrimidine nucleoside phosphorylase, pyrimidine phosphorylase, pyrimidine/purine nucleoside phosphorylase, TDRPASE, ThdPase, thymidine phosphorylase, thymidine Pi deoxyribosyltransferase, thymidine-orthophosphate deoxyribosyltransferase, thymidine:orthophosphate deoxy-D-ribosyltransferase, Tpase, TYMP

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.2 Pentosyltransferases
                2.4.2.4 thymidine phosphorylase

KM Value

KM Value on EC 2.4.2.4 - thymidine phosphorylase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.35
1-(2',6'-dideoxy-alpha-L-lyxo-hexafuranosyl)thymine
25°C, pH 6.5
0.35
1-(2',6'-dideoxy-alpha-L-lyxohexafuranosyl)thymine
in 50 mM potassium phosphate buffer (pH 6.5), at 25°C
0.33
1-(2',6'-dideoxy-beta-D-ribo-hexafuranosyl)thymine
25°C, pH 6.5
0.3 - 0.33
1-(2',6'-dideoxy-beta-D-ribohexafuranosyl)thymine
13.3
1-(Tetrahydro-2-furanyl)-5-fluorouracil
-
-
0.32 - 0.735
2'-deoxyuridine
0.09
2-deoxy-alpha-D-ribose 1-phosphate
pH 7.5, 37°C
0.4
3'-amino-3'-deoxythymidine
0.35
3'-deoxy-2',3'-didehydrothymidine
10
3'-Deoxythymidine
-
in 50 mM phosphate buffer, pH 6.8
0.25 - 0.28
4-thiothymidine
0.4
5'-amino-5'-deoxythymidine
0.3
5'-chloro-5'-deoxythymidine
25°C, pH 6.5
0.2 - 1.72
5'-deoxy-5-fluorouridine
0.4 - 32
5'-Deoxythymidine
0.325
5-fluoro-2'-deoxyuridine
pH 8.0, 37°C
1.3
5-fluorouridine
pH 8.0, 37°C
0.16 - 0.23
5-nitro-2'-deoxyuridine
0.00064 - 2.3
phosphate
0.00166 - 9.3
thymidine
0.0832 - 9.828
thymine
0.275 - 47.6
uridine
additional information
additional information
-