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1-(2',6'-dideoxy-alpha-L-lyxo-hexafuranosyl)thymine + phosphate
?
-
-
-
?
1-(2',6'-dideoxy-alpha-L-lyxohexafuranosyl)thymine + phosphate
thymine + 2,6-dideoxy-L-lyxohexafuranose 1-phosphate
-
-
-
?
1-(2',6'-dideoxy-beta-D-ribo-hexafuranosyl)thymine + phosphate
?
-
-
-
?
1-(2',6'-dideoxy-beta-D-ribohexafuranosyl)thymine + phosphate
?
-
-
-
?
1-(2',6'-dideoxy-beta-D-ribohexafuranosyl)thymine + phosphate
thymine + 2,6-dideoxy-D-ribohexafuranose 1-phosphate
-
-
-
?
1-(tetrahydro-2-furanyl)-5-fluorouracil + phosphate
?
-
i.e. Tegafur
-
-
?
1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidine-2,4(1H,3H)-dione + phosphate
?
-
56% conversion after one h
-
-
?
1-[(2R,4S,5R)-5-(aminomethyl)-4-hydroxytetrahydrofuran-2-yl]-5-methylpyrimidine-2,4(1H,3H)-dione + phosphate
?
-
11% conversion after one h
-
-
?
1-[(2R,4S,5R)-5-(hydroxymethyl)-4-sulfanyltetrahydrofuran-2-yl]-5-methylpyrimidine-2,4(1H,3H)-dione + phosphate
?
-
0.76% conversion after one h
-
-
?
1-[(2R,4S,5S)-4-hydroxy-5-(sulfanylmethyl)tetrahydrofuran-2-yl]-5-methylpyrimidine-2,4(1H,3H)-dione + phosphate
?
-
39% conversion after one h
-
-
?
1-[(2R,4S,5S)-5-(chloromethyl)-4-hydroxytetrahydrofuran-2-yl]-5-methylpyrimidine-2,4(1H,3H)-dione + phosphate
?
-
24% conversion after one h
-
-
?
2'-deoxy-5-nitrouridine + phosphate
5-nitrouracil + 2-deoxy-alpha-D-ribose 1-phosphate
-
-
-
-
?
2'-deoxythymidine + phosphate
thymine + 2-deoxy-D-ribose 1-phosphate
2'-deoxyuridine + phosphate
?
-
-
-
?
2'-deoxyuridine + phosphate
uracil + 2-deoxy-alpha-D-ribose 1-phosphate
-
-
-
r
2'-deoxyuridine + phosphate
uracil + 2-deoxy-D-ribose 1-phosphate
-
-
-
-
?
3'-amino-3'-deoxythymidine + phosphate
?
3'-deoxy-2',3'-didehydrothymidine + phosphate
?
-
-
-
?
3'-deoxy-2',3'-didehydrothymidine + phosphate
thymine + 2,3-dideoxy-2,3-didehydro-D-ribose 1-phosphate
-
-
-
?
3'-deoxythymidine + phosphate
thymine + 2,3-dideoxy-D-ribose 1-phosphate
-
3.2% conversion after one h
-
-
?
3'-thiothymidine + phosphate
thymine + 3-thio-2,3-dideoxy-D-ribose 1-phosphate
-
0.76% conversion after 1 h
-
-
?
3-fluorothymidine + phosphate
3-fluorothymine + 2-deoxy-D-ribose 1-phosphate
-
-
-
-
?
4'-thiothymidine + phosphate
?
-
3.8% conversion after one h
-
-
?
4-thiothymidine + phosphate
4-thiothymine + 2-deoxy-D-ribose 1-phosphate
4-thiothymidine + phosphate
?
-
-
-
?
5'-amino-5'-deoxythymidine + phosphate
?
-
-
-
?
5'-amino-5'-deoxythymidine + phosphate
thymine + 2,5-dideoxy-5-amino-D-ribose 1-phosphate
-
-
-
?
5'-amino-5'-deoxythymidine + phosphate
thymine + 5-amino-2,5-dideoxy-D-ribose 1-phosphate
-
11% conversion after 1 h
-
-
?
5'-chloro-5'-deoxythymidine + phosphate
?
-
-
-
?
5'-chloro-5'-deoxythymidine + phosphate
thymine + 5-chloro-2,5-dideoxy-D-ribose 1-phosphate
-
24% conversion after 1 h
-
-
?
5'-deoxy-5'-fluorothymidine + phosphate
thymine + 5-fluoro-2,5-dideoxy-D-ribose 1-phosphate
-
-
-
-
?
5'-deoxy-5-fluorouridine + phosphate
5-fluorouracil + 5-deoxy-alpha-D-ribose 1-phosphate
-
-
-
r
5'-deoxy-5-fluorouridine + phosphate
5-fluorouracil + 5-deoxy-D-ribose 1-phosphate
-
-
-
-
?
5'-deoxy-5-fluorouridine + phosphate
5-fluorouracil + 5-deoxyribose-1-phosphate
5'-deoxythymidine + phosphate
?
-
-
-
?
5'-deoxythymidine + phosphate
thymine + 2,5-dideoxy-D-ribose 1-phosphate
5'-deoxyuridine + phosphate
uracil + 5-deoxy-D-ribose 1-phosphate
-
-
-
-
?
5'-thiothymidine + phosphate
thymine + 5-thio-2,5-dideoxy-D-ribose 1-phosphate
-
39% conversion after 1 h
-
-
?
5-deoxythymidine + phosphate
thymine + 2,5-dideoxyribose 1-phosphate
-
-
-
-
?
5-fluoro-2'-deoxyuridine + phosphate
5-fluorouracil + 2-deoxy-alpha-D-ribose 1-phosphate
-
-
-
r
5-fluoro-2'-deoxyuridine + phosphate
5-fluorouracil + 2-deoxy-D-ribose 1-phosphate
-
-
-
-
?
5-fluoro-2'-deoxyuridine + phosphate
5-fluorouracil + 2-deoxyribose-1-phosphate
5-fluorouracil + 2-deoxy-alpha-D-ribose 1-phosphate
5-fluoro-2'-deoxyuridine + phosphate
5-fluorouridine + phosphate
5-fluorouracil + alpha-D-ribose 1-phosphate
-
-
-
r
5-fluorouridine + phosphate
5-fluorouracil + D-ribose 1-phosphate
-
-
-
-
?
5-fluorouridine + phosphate
5-fluorouracil + ribose 1-phosphate
5-nitro-2'-deoxyuridine + phosphate
5-nitrouracil + 2-deoxy-D-ribose 1-phosphate
6-azathymidine + phosphate
uracil + deoxyribose-1-phosphate
-
5.4% conversion after one h
-
-
?
bromodeoxyuridine + phosphate
bromouracil + 2-deoxy-D-ribose
deoxythymidine + phosphate
thymine + 2-deoxy-D-ribose 1-phosphate
deoxyuridine + phosphate
uracil + 2-deoxy-D-ribose 1-phosphate
fluorodeoxyuridine + phosphate
fluorouracil + 2-deoxy-D-ribose
-
-
-
-
?
iododeoxyuridine + phosphate
iodouracil + 2-deoxy-D-ribose
thymidine + phosphate
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
thymidine + phosphate
thymine + 2-deoxy-D-ribose 1-phosphate
thymidine + phosphate
thymine + alpha-D-deoxyribose 1-phosphate
-
-
-
r
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
thymidine + phosphate
thymine + 2-deoxy-D-ribose 1-phosphate
thymidine + phosphate
thymine arabinoside + phosphate
thymine + arabinose 1-phosphate
-
-
-
-
?
uracil + 2-deoxy-alpha-D-ribose 1-phosphate
2'-deoxyuridine + phosphate
-
-
-
r
uracil + phosphate
uracil + ribose 1-phosphate
-
88% conversion after one h
-
-
?
uridine + phosphate
uracil + alpha-D-ribose 1-phosphate
-
-
-
r
uridine + phosphate
uracil + D-ribose 1-phosphate
uridine + phosphate
uracil + ribose 1-phosphate
additional information
?
-
2'-deoxythymidine + phosphate
thymine + 2-deoxy-D-ribose 1-phosphate
-
-
-
?
2'-deoxythymidine + phosphate
thymine + 2-deoxy-D-ribose 1-phosphate
-
-
-
-
?
3'-amino-3'-deoxythymidine + phosphate
?
-
-
-
?
3'-amino-3'-deoxythymidine + phosphate
?
at pH 8.0
-
-
?
4-thiothymidine + phosphate
4-thiothymine + 2-deoxy-D-ribose 1-phosphate
-
-
-
-
?
4-thiothymidine + phosphate
4-thiothymine + 2-deoxy-D-ribose 1-phosphate
-
-
-
?
5'-deoxy-5-fluorouridine + phosphate
5-fluorouracil + 5-deoxyribose-1-phosphate
-
-
-
-
?
5'-deoxy-5-fluorouridine + phosphate
5-fluorouracil + 5-deoxyribose-1-phosphate
-
5'-DFUR
-
-
?
5'-deoxythymidine + phosphate
thymine + 2,5-dideoxy-D-ribose 1-phosphate
-
-
-
?
5'-deoxythymidine + phosphate
thymine + 2,5-dideoxy-D-ribose 1-phosphate
-
68% conversion after one h
-
-
?
5-fluoro-2'-deoxyuridine + phosphate
5-fluorouracil + 2-deoxyribose-1-phosphate
-
-
-
-
?
5-fluoro-2'-deoxyuridine + phosphate
5-fluorouracil + 2-deoxyribose-1-phosphate
-
-
-
?
5-fluoro-2'-deoxyuridine + phosphate
5-fluorouracil + 2-deoxyribose-1-phosphate
-
-
-
-
r
5-fluorouracil + 2-deoxy-alpha-D-ribose 1-phosphate
5-fluoro-2'-deoxyuridine + phosphate
-
the enzyme converts 5-fluorouracil to 5-fluoro-2'-deoxyuridine, activating the prodrug, overview. This action can only take place if there is enough co-substrate. 5-Fluorouracil prodrugs and metabolism, detailed overview
5-fluoro-2'-deoxyuridine is further converted by thymidine kinase to 5-fluoro-2'-deoxyuridine 5'-monophosphate
-
?
5-fluorouracil + 2-deoxy-alpha-D-ribose 1-phosphate
5-fluoro-2'-deoxyuridine + phosphate
-
the enzyme converts 5-fluorouracil to 5-fluoro-2'-deoxyuridine, activating the prodrug, overview. This action can only take place if there is enough co-substrate
-
-
?
5-fluorouridine + phosphate
5-fluorouracil + ribose 1-phosphate
-
-
-
-
?
5-fluorouridine + phosphate
5-fluorouracil + ribose 1-phosphate
-
-
-
-
?
5-nitro-2'-deoxyuridine + phosphate
5-nitrouracil + 2-deoxy-D-ribose 1-phosphate
-
-
-
-
?
5-nitro-2'-deoxyuridine + phosphate
5-nitrouracil + 2-deoxy-D-ribose 1-phosphate
-
-
-
-
?
5-nitro-2'-deoxyuridine + phosphate
5-nitrouracil + 2-deoxy-D-ribose 1-phosphate
-
-
-
?
5-nitro-2'-deoxyuridine + phosphate
5-nitrouracil + 2-deoxy-D-ribose 1-phosphate
-
-
-
-
?
bromodeoxyuridine + phosphate
bromouracil + 2-deoxy-D-ribose
-
-
-
-
?
bromodeoxyuridine + phosphate
bromouracil + 2-deoxy-D-ribose
-
-
-
-
?
bromodeoxyuridine + phosphate
bromouracil + 2-deoxy-D-ribose
-
at 40% the rate of thymidine
-
-
?
deoxythymidine + phosphate
thymine + 2-deoxy-D-ribose 1-phosphate
-
-
-
-
?
deoxythymidine + phosphate
thymine + 2-deoxy-D-ribose 1-phosphate
-
-
-
-
?
deoxyuridine + phosphate
uracil + 2-deoxy-D-ribose 1-phosphate
-
-
-
-
?
deoxyuridine + phosphate
uracil + 2-deoxy-D-ribose 1-phosphate
-
-
-
-
r
deoxyuridine + phosphate
uracil + 2-deoxy-D-ribose 1-phosphate
-
1.2-1.4 times the rate of thymidine at pH 5.7
-
-
?
deoxyuridine + phosphate
uracil + 2-deoxy-D-ribose 1-phosphate
-
-
-
-
?
deoxyuridine + phosphate
uracil + 2-deoxy-D-ribose 1-phosphate
-
-
-
-
?
iododeoxyuridine + phosphate
iodouracil + 2-deoxy-D-ribose
-
-
-
-
?
iododeoxyuridine + phosphate
iodouracil + 2-deoxy-D-ribose
-
-
-
-
?
thymidine + arsenate
?
-
-
-
-
?
thymidine + arsenate
?
-
-
-
-
?
thymidine + arsenate
?
-
-
-
-
?
thymidine + phosphate
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
-
-
-
-
?
thymidine + phosphate
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
-
-
-
-
r
thymidine + phosphate
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
-
-
-
?
thymidine + phosphate
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
-
substrate binding induces domain movement, which leads to the closed conformation of the active site and initiates phosphorylation, molecular dynamic simulation, overview
-
-
r
thymidine + phosphate
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
-
-
-
-
r
thymidine + phosphate
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
-
-
-
-
?
thymidine + phosphate
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
-
-
-
-
r
thymidine + phosphate
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
-
-
-
?
thymidine + phosphate
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
-
-
-
r
thymidine + phosphate
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
-
-
-
-
r
thymidine + phosphate
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
-
-
-
r
thymidine + phosphate
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
-
-
-
-
r
thymidine + phosphate
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
-
-
-
r
thymidine + phosphate
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
-
-
-
-
r
thymidine + phosphate
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
-
-
2-deoxy-alpha-D-ribose 1-phosphate strongly promoted neovascularization
-
?
thymidine + phosphate
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
-
Asp203 plays an important role for loop stabilization required for efficient enzyme catalysis
-
-
r
thymidine + phosphate
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
Asp203 plays an important role to afford the substrate-binding site loop stabilization that is required for efficient enzyme catalysis
-
-
r
thymidine + phosphate
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
the enzyme catalyzes the reversible cleavage of the glycosidic bond of pyrimidine 2'-deoxynucleotides, most likely through SN2-like transition state involving nucleobase, 2'-deoxyribose and phosphate. The active site consists of residues His116, Ser117, Leu148, Arg202, Val208, Ile214, Lys221 and Val241
-
-
r
thymidine + phosphate
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
-
-
-
-
?
thymidine + phosphate
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
-
-
-
-
r
thymidine + phosphate
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
-
-
-
r
thymidine + phosphate
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
-
-
-
-
r
thymidine + phosphate
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
-
-
-
?
thymidine + phosphate
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
-
-
-
?
thymidine + phosphate
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
-
-
-
-
?
thymidine + phosphate
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
-
-
-
-
r
thymidine + phosphate
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
-
-
-
-
r
thymidine + phosphate
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
-
-
-
?
thymidine + phosphate
thymine + 2-deoxy-D-ribose 1-phosphate
-
-
-
?
thymidine + phosphate
thymine + 2-deoxy-D-ribose 1-phosphate
-
-
-
-
?
thymidine + phosphate
thymine + 2-deoxy-D-ribose 1-phosphate
-
-
-
?
thymidine + phosphate
thymine + 2-deoxy-D-ribose 1-phosphate
-
-
-
-
?
thymidine + phosphate
thymine + 2-deoxy-D-ribose 1-phosphate
-
-
-
?
thymidine + phosphate
thymine + 2-deoxy-D-ribose 1-phosphate
-
-
-
-
?
thymidine + phosphate
thymine + 2-deoxy-D-ribose 1-phosphate
-
-
-
r
thymidine + phosphate
thymine + 2-deoxy-D-ribose 1-phosphate
-
-
-
-
r
thymidine + phosphate
thymine + 2-deoxy-D-ribose 1-phosphate
-
in the reverse reaction only alpha-D-2-deoxyribose 1-phosphate is accepted as substrate
-
r
thymidine + phosphate
thymine + 2-deoxy-D-ribose 1-phosphate
SN1 mechanism for the phosphorolysis reaction, relevant interaction between the His85 imidazole ring and the O2 of thymidine suggesting that this highly conserved residue could play an important role in the catalytic mechanism of TPase
-
-
?
thymidine + phosphate
thymine + 2-deoxy-D-ribose 1-phosphate
-
86% conversion after one h
-
-
?
thymidine + phosphate
thymine + 2-deoxy-D-ribose 1-phosphate
-
-
-
-
?
thymidine + phosphate
thymine + 2-deoxy-D-ribose 1-phosphate
-
-
-
-
?
thymidine + phosphate
thymine + 2-deoxy-D-ribose 1-phosphate
-
-
-
?
thymidine + phosphate
thymine + 2-deoxy-D-ribose 1-phosphate
-
-
638456, 638459, 638460, 658872, 659360, 675046, 685026, 685817, 685912, 685914, 686140, 686143, 686594, 688264, 689162, 689163, 689244, 689262, 689271 -
-
?
thymidine + phosphate
thymine + 2-deoxy-D-ribose 1-phosphate
-
-
-
-
ir
thymidine + phosphate
thymine + 2-deoxy-D-ribose 1-phosphate
-
-
-
r
thymidine + phosphate
thymine + 2-deoxy-D-ribose 1-phosphate
-
-
-
r
thymidine + phosphate
thymine + 2-deoxy-D-ribose 1-phosphate
-
-
-
r
thymidine + phosphate
thymine + 2-deoxy-D-ribose 1-phosphate
-
-
-
-
r
thymidine + phosphate
thymine + 2-deoxy-D-ribose 1-phosphate
-
-
-
?
thymidine + phosphate
thymine + 2-deoxy-D-ribose 1-phosphate
-
-
-
-
?
thymidine + phosphate
thymine + 2-deoxy-D-ribose 1-phosphate
-
-
-
?
thymidine + phosphate
thymine + 2-deoxy-D-ribose 1-phosphate
-
enzyme is enantioselective, acts only on the naturally occurring D-thymidine and some D-thymidine analogs, but not on their L-counterparts
-
?
thymidine + phosphate
thymine + 2-deoxy-D-ribose 1-phosphate
-
intact platelets degrade thymidine but are not able to synthesize thymidine from thymine
-
-
?
thymidine + phosphate
thymine + 2-deoxy-D-ribose 1-phosphate
-
the enzyme confers resistance to apoptosis induced by hypoxia. The enzymatic degradation of thymidine by thymidine phosphorylase is required for the inhibition of hypoxia-induced apoptosis. The enzyme can confer resistance to apoptosis in addition to its angiogenic activity. The enzyme must play some role in the development or malignancy of tumors. Involved in invasion and metastasis of some solid tumors
-
-
?
thymidine + phosphate
thymine + 2-deoxy-D-ribose 1-phosphate
-
the enzyme plays a crucial role in intratumoral angiogenesis, which occurs in the early phase of ovarian cancer, or influences angiogenesis indirectly
-
-
?
thymidine + phosphate
thymine + 2-deoxy-D-ribose 1-phosphate
-
-
-
-
?
thymidine + phosphate
thymine + 2-deoxy-D-ribose 1-phosphate
-
-
-
-
r
thymidine + phosphate
thymine + 2-deoxy-D-ribose 1-phosphate
-
-
-
?
thymidine + phosphate
thymine + 2-deoxy-D-ribose 1-phosphate
-
-
-
-
?
thymidine + phosphate
thymine + 2-deoxy-D-ribose 1-phosphate
-
-
-
r
thymidine + phosphate
thymine + 2-deoxy-D-ribose 1-phosphate
-
-
-
-
?
thymidine + phosphate
thymine + 2-deoxy-D-ribose 1-phosphate
-
-
-
r
thymidine + phosphate
thymine + 2-deoxy-D-ribose 1-phosphate
-
-
-
?
thymidine + phosphate
thymine + 2-deoxy-D-ribose 1-phosphate
-
-
-
?
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
thymidine + phosphate
-
-
-
-
r
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
thymidine + phosphate
-
-
-
r
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
thymidine + phosphate
-
-
-
-
r
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
thymidine + phosphate
-
-
-
r
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
thymidine + phosphate
-
-
-
r
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
thymidine + phosphate
-
-
-
-
r
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
thymidine + phosphate
-
-
-
r
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
thymidine + phosphate
-
-
-
r
thymine + 2-deoxy-D-ribose 1-phosphate
thymidine + phosphate
-
-
-
-
?
thymine + 2-deoxy-D-ribose 1-phosphate
thymidine + phosphate
-
enzyme also catalyzes the nucleoside deoxyribosyltransferase reaction with pyrimidine deoxyribonucleosides, ec2.4.2.6
-
-
?
thymine + 2-deoxy-D-ribose 1-phosphate
thymidine + phosphate
-
enzyme also catalyzes the nucleoside deoxyribosyltransferase reaction with pyrimidine deoxyribonucleosides, ec2.4.2.6
-
-
?
thymine + 2-deoxy-D-ribose 1-phosphate
thymidine + phosphate
-
-
-
-
?
thymine + 2-deoxy-D-ribose 1-phosphate
thymidine + phosphate
-
enzyme is enantioselective, acts only on the naturally occurring D-thymidine and some D-thymidine analogs, but not on their L-counterparts
-
-
?
thymine + 2-deoxy-D-ribose 1-phosphate
thymidine + phosphate
-
enzyme also catalyzes the nucleoside deoxyribosyltransferase reaction with pyrimidine deoxyribonucleosides, ec2.4.2.6
-
-
?
thymine + 2-deoxy-D-ribose 1-phosphate
thymidine + phosphate
-
degradation of uridine in tumor specimen
-
-
?
thymine + 2-deoxy-D-ribose 1-phosphate
thymidine + phosphate
-
enzyme also catalyzes the nucleoside deoxyribosyltransferase reaction with pyrimidine deoxyribonucleosides, ec2.4.2.6
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-
?
thymine + 2-deoxy-D-ribose 1-phosphate
thymidine + phosphate
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in Escherichia coli and Salmonella typhimurium thymidine phosphorylase plays an important role in metabolism of thymine auxotrophs and is necessary for the conversion of exogenous thymine to thymidine
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?
uridine + phosphate
uracil + D-ribose 1-phosphate
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-
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-
?
uridine + phosphate
uracil + D-ribose 1-phosphate
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56% conversion after 1 h
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?
uridine + phosphate
uracil + D-ribose 1-phosphate
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-
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?
uridine + phosphate
uracil + ribose 1-phosphate
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the activities of uridine, deoxyuridine and thymidine phosphorylases from Giardia lamblia remain associated throughout purification, suggesting that a single enzyme is responsible for the 3 activities
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?
uridine + phosphate
uracil + ribose 1-phosphate
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-
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-
?
uridine + phosphate
uracil + ribose 1-phosphate
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-
-
?
additional information
?
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the enzyme in some tissues also catalyzes deoxyribonucleosyltransferase reaction of the type catalyzed by EC 2.4.2.6: 2-deoxy-D-ribosyl-base1 + base2 = 2-deoxy-D-ribosyl-base2 + base1
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?
additional information
?
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no substrate: deoxycytidine
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?
additional information
?
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specific for deoxyribonucleosides
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-
?
additional information
?
-
-
the enzyme in some tissues also catalyzes deoxyribonucleosyltransferase reaction of the type catalyzed by EC 2.4.2.6: 2-deoxy-D-ribosyl-base1 + base2 = 2-deoxy-D-ribosyl-base2 + base1
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-
?
additional information
?
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-
purine deoxyribonucleosides and ribonucleosides are not cleaved
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-
?
additional information
?
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-
3'-amino-3'-deoxythymidine is not a thymidine phosphorylase substrate at pH 6.5, no activity with uridine and methyluridine
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-
?
additional information
?
-
3'-amino-3'-deoxythymidine is not a thymidine phosphorylase substrate at pH 6.5, no activity with uridine and methyluridine
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-
?
additional information
?
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no activity with 3'beta-thymidine, 4'-thio-1'-alpha-thymidine, 1-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]thymine, 5-methyl-2-pyrimidinone nucleoside, and deoxycytidine
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?
additional information
?
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the 3'-OH group is important for nucleotide binding, substrate analogues and substrate specificity, overview
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?
additional information
?
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no activity with arabinosyluracil and 2',3'-dideoxyuridine
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?
additional information
?
-
the pyrimidine moiety of thymidine is involved in making hydrogen bonds with the side chains of residues Arg171, Ser186, Lys190, while the deoxyribose moiety form hydrogen bond with a co-crystallized water molecule. The phosphate ion shows hydrogen bonding with Lys84, Ser95, Ser113, and a water molecule
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-
additional information
?
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-
the enzyme in some tissues also catalyzes deoxyribonucleosyltransferase reaction of the type catalyzed by EC 2.4.2.6: 2-deoxy-D-ribosyl-base1 + base2 = 2-deoxy-D-ribosyl-base2 + base1
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-
?
additional information
?
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closing/opening motion in the presence of substrate, product, and transition state, molecular dynamic simulation
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?
additional information
?
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substrate specificity, overview
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-
additional information
?
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substrate specificity, overview
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-
additional information
?
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-
no substrate: deoxycytidine
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-
?
additional information
?
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the phosphorolytic acitvities towards thymidine, 5'-deoxy-5-fluorouridine and 1-(tetrahydro-2-furanyl)-5-fluorouracil remain closely parallel during purification
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-
?
additional information
?
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-
purine deoxyribonucleosides are no substrates
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-
?
additional information
?
-
-
the enzyme in some tissues also catalyzes deoxyribonucleosyltransferase reaction of the type catalyzed by EC 2.4.2.6: 2-deoxy-D-ribosyl-base1 + base2 = 2-deoxy-D-ribosyl-base2 + base1
-
-
?
additional information
?
-
-
the enzyme in some tissues also catalyzes deoxyribonucleosyltransferase reaction of the type catalyzed by EC 2.4.2.6: 2-deoxy-D-ribosyl-base1 + base2 = 2-deoxy-D-ribosyl-base2 + base1
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-
?
additional information
?
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-
role in thymidine metabolism, homeostasis, development and regeneration of central nervous system and formation of blood/brain barrier
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-
?
additional information
?
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-
formation of blood/brain barrier and repair following brain injury
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-
?
additional information
?
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identical to platelet-derived endothelial cell growth factor
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?
additional information
?
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identical to platelet-derived endothelial cell growth factor
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?
additional information
?
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mitogenic effect, promotes endothelial cell proliferation
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-
?
additional information
?
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-
angiogenic activity
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-
?
additional information
?
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-
angiogenic activity
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?
additional information
?
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-
angiogenic activity
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-
?
additional information
?
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-
angiogenic activity
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-
?
additional information
?
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-
angiogenic activity
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-
?
additional information
?
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-
angiogenic activity
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?
additional information
?
-
expression of PD-ECGF/TP may play an important role in the progression of solid tumors
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-
?
additional information
?
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important role in nucleoside metabolism, implicated in angiogenesis and apoptosis
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?
additional information
?
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important role in nucleoside metabolism, implicated in angiogenesis and apoptosis
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-
?
additional information
?
-
thymidine phosphorylase and uridine phosphorylase contribute in the conversion of 5'-deoxy-5-fluorouridine into 5-fluorouracil and the conversion of 5-fluorouracil into its active metabolites in peripheral blood mononuclear cell, but thymidine phosphorylase seems to be the most important enzyme for these reactions in PBMC
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-
?
additional information
?
-
molecular modeling based on an X-ray structure of human TP indicates that TP is likely to be mechanistically similar to all other natural members of the class in proceeding through a a oxacarbenium-like transition state or states
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?
additional information
?
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-
molecular modeling based on an X-ray structure of human TP indicates that TP is likely to be mechanistically similar to all other natural members of the class in proceeding through a a oxacarbenium-like transition state or states
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?
additional information
?
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the enzyme stimulates formation of focal adhesions and the phosphorylation of Tyr397 of focal adhesion kinase, and it induces the expression and/or secretion of other angiogenic factors, overview. Thymidine phosphorylase promotes tumor growth and metastasis by preventing apoptosis and inducing angiogenesis, detailed overview. As gliostatin from fibroma cells, the enzyme inhibits the growth of both astrocytes and glial tumor cells
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?
additional information
?
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thymidine phosphorylase is identical with platelet-derived endothelial cell growth factor, PD-ECGF, which promotes angiogenesis. The mechanism of endometrial angiogenesis involves thymidine phosphorylase and stimulation by ovarian steroids of production of angiogenic regulators by endometrial epithelium and stroma which then act on the endothelium
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?
additional information
?
-
initial velocity studies showed an intersecting pattern, consistent with substrate-enzyme-co-substrate complex formation, and a binding pattern indicating that the binding of the substrate interferes with the binding of the co-substrate and vice versa
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-
additional information
?
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-
initial velocity studies showed an intersecting pattern, consistent with substrate-enzyme-co-substrate complex formation, and a binding pattern indicating that the binding of the substrate interferes with the binding of the co-substrate and vice versa
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-
additional information
?
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-
specificity towards the deoxyribosyl moiety of the substrate
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-
?
additional information
?
-
-
nonsubstituted pyrimidine moiety or one which is substituted in position 5 required
-
-
?
additional information
?
-
-
the enzyme in some tissues also catalyzes deoxyribonucleosyltransferase reaction of the type catalyzed by EC 2.4.2.6: 2-deoxy-D-ribosyl-base1 + base2 = 2-deoxy-D-ribosyl-base2 + base1
-
-
?
additional information
?
-
-
the enzyme in some tissues also catalyzes deoxyribonucleosyltransferase reaction of the type catalyzed by EC 2.4.2.6: 2-deoxy-D-ribosyl-base1 + base2 = 2-deoxy-D-ribosyl-base2 + base1
-
-
?
additional information
?
-
-
the enzyme in some tissues also catalyzes deoxyribonucleosyltransferase reaction of the type catalyzed by EC 2.4.2.6: 2-deoxy-D-ribosyl-base1 + base2 = 2-deoxy-D-ribosyl-base2 + base1
-
-
?
additional information
?
-
-
the enzyme in some tissues also catalyzes deoxyribonucleosyltransferase reaction of the type catalyzed by EC 2.4.2.6: 2-deoxy-D-ribosyl-base1 + base2 = 2-deoxy-D-ribosyl-base2 + base1
-
-
?
additional information
?
-
-
no substrate: deoxycytidine
-
-
?
additional information
?
-
-
no substrate: deoxycytidine
-
-
?
additional information
?
-
-
no substrates: deoxyadenosine, deoxyguanosine
-
-
?
additional information
?
-
-
no substrates: deoxyadenosine, deoxyguanosine
-
-
?
additional information
?
-
-
specific for deoxyribonucleosides
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-
?