2.4.2.44: S-methyl-5'-thioinosine phosphorylase

This is an abbreviated version!
For detailed information about S-methyl-5'-thioinosine phosphorylase, go to the full flat file.

Reaction

Synonyms

methylthioinosine phosphorylase, MTI phosphorylase, MTIP, PA3004

ECTree

     2 Transferases

         2.4 Glycosyltransferases

             2.4.2 Pentosyltransferases

                2.4.2.44 S-methyl-5'-thioinosine phosphorylase

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Results	in table
2392	AA Sequence
2	Cloned(Commentary)
2	Crystallization (Commentary)
4	Inhibitors
3	kcat/KM [mM/s]
7	Ki Value [mM]
5	KM Value [mM]
1	Natural Substrates/ Products (Substrates)
1	Organism
3	Pathway
1	pH Optimum
1	Purification (Commentary)
1	Reaction
1	Reference
8	Substrates and Products (Substrate)
2	Subunits
4	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
5	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 2.4.2.44 - S-methyl-5'-thioinosine phosphorylase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

5'-methylthioinosine + phosphate

hypoxanthine + 5-methylthio-alpha-D-ribose 1-phosphate

Pseudomonas aeruginosa

Q9HZK1

-

707535

-

-

?

adenosine + phosphate

adenine + alpha-D-ribose 1-phosphate

Pseudomonas aeruginosa

Q9HZK1

weak substrate

707535

-

-

?

adenosine + phosphate

adenine + D-ribose 1-phosphate

Pseudomonas aeruginosa

Q9HZK1

-

707535

-

-

?

inosine + phosphate

hypoxanthine + alpha-D-ribose 1-phosphate

Pseudomonas aeruginosa

Q9HZK1

the catalytic efficiency (kcat/Km) for S-methyl-5'-thioinosine is 290 times larger than for inosine

707535

-

-

?

inosine + phosphate

hypoxanthine + D-ribose 1-phosphate

Pseudomonas aeruginosa

Q9HZK1

-

707535

-

-

?

S-methyl-5'-thioinosine + phosphate

hypoxanthine + S-methyl-5-thio-alpha-D-ribose 1-phosphate

2 entries

additional information

?

-

2 entries

S-methyl-5'-thioinosine + phosphate

hypoxanthine + S-methyl-5-thio-alpha-D-ribose 1-phosphate

Pseudomonas aeruginosa

Q9HZK1

the enzyme is involved in catabolism of 5'-methylthioadenosine in Pseudomonas aeruginosa. S-Methyl-5'-thioadenosine is converted to S-methyl-5'-thioinosine and hypoxanthine but not to adenine

707535

-

-

?

S-methyl-5'-thioinosine + phosphate

hypoxanthine + S-methyl-5-thio-alpha-D-ribose 1-phosphate

Pseudomonas aeruginosa

Q9HZK1

the methylthio group of S-methyl-5'-thioinosine is important for both substrate binding and catalysis

707535

-

-

?

additional information

?

-

Pseudomonas aeruginosa

Q9HZK1

S-methyl-5'-thioadenosine is not a substrate

707535

-

-

?

additional information

?

-

Pseudomonas aeruginosa

-

S-methyl-5'-thioadenosine is not a substrate

707535

-

-

?