2.4.2.48: tRNA-guanine15 transglycosylase
This is an abbreviated version!
For detailed information about tRNA-guanine15 transglycosylase, go to the full flat file.
Word Map on EC 2.4.2.48
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2.4.2.48
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horikoshii
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arctgt
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preq0
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pyrococcus
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7-cyano-7-deazaguanine
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anticodon
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d-loop
- 2.4.2.48
- horikoshii
- arctgt
- preq0
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pyrococcus
- 7-cyano-7-deazaguanine
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anticodon
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d-loop
Reaction
Synonyms
archaeosine tRNA-guanine transglycosylase, archaeosine tRNAguanine transglycosylase, ArcTGT, multisite-specific archaeosine tRNA-guanine transglycosylase, Ta1493, TGT, transfer ribonucleic acid guanine15 transglycosylase, tRNA guanine15 transglycosidase, tRNA-guanine transglycosylase
ECTree
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Engineering
Engineering on EC 2.4.2.48 - tRNA-guanine15 transglycosylase
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additional information
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the C-terminal extension of the enzyme is not required for the selection of G15 as the site of base exchange. Truncated forms of Pyrococcus furiosus TGT retain their specificity for guanine exchange at position 15. Deletion of the PUA domain causes a 4fold drop in the observed kcat and results in a 75fold increased Km for tRNAAsp compared with full-length TGT