2.4.2.48: tRNA-guanine15 transglycosylase
This is an abbreviated version!
For detailed information about tRNA-guanine15 transglycosylase, go to the full flat file.
Word Map on EC 2.4.2.48
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2.4.2.48
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horikoshii
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arctgt
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preq0
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pyrococcus
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7-cyano-7-deazaguanine
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anticodon
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d-loop
- 2.4.2.48
- horikoshii
- arctgt
- preq0
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pyrococcus
- 7-cyano-7-deazaguanine
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anticodon
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d-loop
Reaction
Synonyms
archaeosine tRNA-guanine transglycosylase, archaeosine tRNAguanine transglycosylase, ArcTGT, multisite-specific archaeosine tRNA-guanine transglycosylase, Ta1493, TGT, transfer ribonucleic acid guanine15 transglycosylase, tRNA guanine15 transglycosidase, tRNA-guanine transglycosylase
ECTree
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Substrates Products
Substrates Products on EC 2.4.2.48 - tRNA-guanine15 transglycosylase
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REACTION DIAGRAM
guanine13 in tRNA(Leu) + 7-cyano-7-carbaguanine
7-cyano-7-carbaguanine13 in tRNA(Leu) + guanine
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?
guanine15 in tRNA(Leu) + 7-cyano-7-carbaguanine
7-cyano-7-carbaguanine15 in tRNA(Leu) + guanine
tRNAguanine + 7-cyano-7-deazaguanine
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archaeal TGT substitutes 7-cyano-7-deazaguanine for the G in position 15 of tRNA as the first step in archaeosine formation
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additional information
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the enzyme catalyzes a transglycosylation reaction in which guanine is eliminated from position 15 of the tRNA and an archaeosine precursor (preQ0) is inserted. The enzyme is able to utilize both guanine and the 7-deazaguanine base preQ0 as substrates, but not other 7-deazaguanine bases, and is able to modify tRNA from all three phylogenetic domains. The enzyme shows good activity with the tRNASer transcript as well as tRNA from Escherichia coli and yeast
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7-cyano-7-carbaguanine15 in tRNA + guanine
key enzyme for the biosynthetic pathway leading to archaeosine in archaeal tRNAs
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guanine15 in tRNA + 7-cyano-7-carbaguanine
7-cyano-7-carbaguanine15 in tRNA + guanine
archaeosine base and 7-aminomethyl-7-deazaguanine are not incorporated into tRNA by this enzyme. Does not require ATP for the base replacement reaction
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?
guanine15 in tRNA + 7-cyano-7-carbaguanine
7-cyano-7-carbaguanine15 in tRNA + guanine
key enzyme for the biosynthetic pathway leading to archaeosine in archaeal tRNAs
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?
guanine15 in tRNA + 7-cyano-7-carbaguanine
7-cyano-7-carbaguanine15 in tRNA + guanine
archaeosine base and 7-aminomethyl-7-deazaguanine are not incorporated into tRNA by this enzyme. Does not require ATP for the base replacement reaction
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guanine15 in tRNA + 7-cyano-7-carbaguanine
7-cyano-7-carbaguanine15 in tRNA + guanine
i.e. 7-(cyano)-7-deazaguanine = preQ0
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guanine15 in tRNA + 7-cyano-7-carbaguanine
7-cyano-7-carbaguanine15 in tRNA + guanine
i.e. 7-(cyano)-7-deazaguanine = preQ0. Haloferax volcanii tRNASer is used as substrate
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guanine15 in tRNA + 7-cyano-7-carbaguanine
7-cyano-7-carbaguanine15 in tRNA + guanine
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guanine15 in tRNA + 7-cyano-7-carbaguanine
7-cyano-7-carbaguanine15 in tRNA + guanine
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?
7-cyano-7-deazaguanine15 in tRNA + guanine
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guanine15 in tRNA + 7-cyano-7-deazaguanine
7-cyano-7-deazaguanine15 in tRNA + guanine
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?
guanine15 in tRNA + 7-cyano-7-deazaguanine
7-cyano-7-deazaguanine15 in tRNA + guanine
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?
7-cyano-7-carbaguanine15 in tRNA(Leu) + guanine
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guanine15 in tRNA(Leu) + 7-cyano-7-carbaguanine
7-cyano-7-carbaguanine15 in tRNA(Leu) + guanine
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guanine15 in tRNA(Leu) + 7-cyano-7-carbaguanine
7-cyano-7-carbaguanine15 in tRNA(Leu) + guanine
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?