2.4.2.6: nucleoside deoxyribosyltransferase
This is an abbreviated version!
For detailed information about nucleoside deoxyribosyltransferase, go to the full flat file.
Word Map on EC 2.4.2.6
Reaction
Synonyms
2'-deoxyribosyltransferase, 2'-N-deoxyribosyltransferase, Chro_1188, CtNDT, deoxynucleoside 5-monophosphate N-glycosidase, deoxyribose transferase, deoxyribosyltransferase, nucleoside, DRTase I, DRTase II, GQR93_14380, LaNDT, LhNDT, LlNDT, LmPDT, LrNDT, N-deoxyribosyltransferase, N-deoxyribosyltransferase II, NDRT, NdRT-II, NDT, NDT-II, NDT4, NTD, nucleoside 2'-deoxyribosyltransferase, nucleoside 2'-deoxyribosyltransferase type II, nucleoside 2-deoxyribosyltransferase, nucleoside deoxyribosyltransferase I, nucleoside deoxyribosyltransferase II, nucleoside N-deoxyribosyltransferase, nucleoside trans-N-deoxyribosylase, PDT, purine nucleoside 2'-deoxyribosyltransferase, purine(pyrimidine) nucleoside:purine(pyrimidine) deoxyribosyl transferase, RCL, Tb927.5.1360, TbPDT, trans-deoxyribosylase, trans-N-deoxyribosylase, trans-N-glycosidase, transdeoxyribosylase, type I NDT, YejD
ECTree
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Reference on EC 2.4.2.6 - nucleoside deoxyribosyltransferase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Roush, A.H.; Betz, R.F.
Purification and properties of trans-N-deoxyribosylase
J. Biol. Chem.
233
261-266
1958
Lactobacillus helveticus
Steenkamp, D.J.
The purine-2-deoxyribonucleosidase from Crithidia luciliae. Purification and trans-N-deoxyribosylase activity
Eur. J. Biochem.
197
431-439
1991
Crithidia luciliae
Cardinaud, R.
Nucleoside deoxyribosyltransferase from Lactobacillus helveticus
Methods Enzymol.
51
446-455
1978
Lactobacillus helveticus
Holguin, J.; Cardinaud, R.
trans-N-Deoxyribosylase: substrate specificity studies. Purine bases as acceptors
Eur. J. Biochem.
54
515-520
1975
Lactobacillus helveticus
Danzin, C.; Cardinaud, R.
Deoxyribosyl transfer catalysis with trans-N-deoxyribosylase. Kinetic studies of purine-to-purine trans-N-deoxyribosylase
Eur. J. Biochem.
48
255-262
1974
Lactobacillus helveticus
Danzin, C.; Cardinaud, R.
Deoxyribosyl transfer catalysis with trans-N-deoxyribosylase. Kinetic study of purine(pyrimidine) to pyrimidine(purine) trans-N-deoxyribosylase
Eur. J. Biochem.
62
365-372
1976
Lactobacillus helveticus
Uerkvitz, W.
Trans-N-deoxyribosylase from Lactobacillus helveticus. Crystallization and properties
Eur. J. Biochem.
23
387-395
1971
Lactobacillus helveticus
Cook, W.J.; Short, S.A.; Ealick, S.E.
Crystallization and preliminary X-ray investigation of recombinant Lactobacillus leichmannii nucleoside deoxyribosyltransferase
J. Biol. Chem.
265
2682-2683
1990
Lactobacillus leichmannii
Huang, M.C.; Montgomery, J.A.; Thorpe, M.C.; Stewart, E.L.; Secrist III, J.A.; Blakley, R.L.
Formation of 3-(2-deoxyribofuranosyl) and 9-(2-deoxyribofuranosyl) nucleosides of 8-substituted purines by nucleoside deoxyribosyltransferase
Arch. Biochem. Biophys.
222
133-144
1983
Lactobacillus leichmannii
Cardinaud, R.; Holguin, J.
Nucleoside deoxyribosyltransferase-II from Lactobacillus helveticus Substrate specificity studied. Pyrimidine bases as acceptors
Biochim. Biophys. Acta
568
339-347
1979
Lactobacillus helveticus
Pistotnik, E.; Sakamoto, H.; Pochet, S.; Namane, A.; Barzu, O.
Assay of nucleoside 2-deoxyribosyltransferase activity with pyruvate kinase/lactate dehydrogenase coupling system
Anal. Biochem.
271
192-193
1999
Lactobacillus sp.
Becker, J.; Brendel, M.
Rapid purification and characterization of two distinct N-deoxyribosyltransferases of Lactobacillus leichmannii
Biol. Chem. Hoppe-Seyler
377
357-362
1996
Lactobacillus leichmannii
Kaminski, P.A.
Functional cloning, heterologous expression, and purification of two different N-deoxyribosyltransferases from Lactobacillus helveticus
J. Biol. Chem.
277
14400-14407
2002
Lactobacillus helveticus (Q8RLY5), Lactobacillus helveticus
Okuyama, K.; Shibuya, S.; Hamamoto, T.; Noguchi, T.
Enzymatic synthesis of 2'-deoxyguanosine with nucleoside deoxyribosyltransferase-II
Biosci. Biotechnol. Biochem.
67
989-995
2003
Lactobacillus helveticus
Mueller, M.; Hutchinson, L.K.; Guengerich, F.P.
Addition of deoxyribose to guanine and modified DNA bases by Lactobacillus helveticus trans-N-deoxyribosylase
Chem. Res. Toxicol.
9
1140-1144
1996
Lactobacillus helveticus
Porter, D.J.T.; Short, S.A.
Nucleoside 2-deoxyribosyltransferase. Pre-steady-state kinetic analysis of native enzyme and mutant enzyme with an alanyl residue replacing Glu-98
J. Biol. Chem.
270
15557-15562
1995
Lactobacillus leichmannii
Fernandez-Lucas, J.; Condezo, L.A.; Martinez-Lagos, F.; Sinisterra, J.V.
Synthesis of 2-deoxyibosylnucleosides using new 2-deoxyribosyltransferase microorganism producers
Enzyme Microb. Technol.
40
1147-1155
2007
Weizmannia coagulans, Lactobacillus sp., Psychrobacter immobilis, Peribacillus psychrosaccharolyticus, Weizmannia coagulans CECT 12, Lactobacillus sp. CECT 4219, Peribacillus psychrosaccharolyticus CECT 4074, Psychrobacter immobilis CECT 4492
-
Ghiorghi, Y.K.; Zeller, K.I.; Dang, C.V.; Kaminski, P.A.
The c-Myc target gene Rcl (C6orf108) encodes a novel enzyme, deoxynucleoside 5-monophosphate N-glycosidase
J. Biol. Chem.
282
8150-8156
2007
Rattus norvegicus
Bosch, J.; Robien, M.A.; Mehlin, C.; Boni, E.; Riechers, A.; Buckner, F.S.; Van Voorhis, W.C.; Myler, P.J.; Worthey, E.A.; DeTitta, G.; Luft, J.R.; Lauricella, A.; Gulde, S.; Anderson, L.A.; Kalyuzhniy, O.; Neely, H.M.; Ross, J.; Earnest, T.N.; Soltis, M.; Schoenfeld, L.; Zucker, F.; Merritt, E.A.; Fan, E.; Verlinde, C.L.; Hol, W.G.
Using fragment cocktail crystallography to assist inhibitor design of Trypanosoma brucei nucleoside 2-deoxyribosyltransferase
J. Med. Chem.
49
5939-5946
2006
Trypanosoma brucei
Miyamoto, Y.; Masaki, T.; Chohnan, S.
Characterization of N-deoxyribosyltransferase from Lactococcus lactis subsp. lactis
Biochim. Biophys. Acta
1774
1323-1330
2007
Lactococcus lactis
Kaminski, P.A.; Dacher, P.; Dugue, L.; Pochet, S.
In vivo reshaping the catalytic site of nucleoside 2-deoxyribosyltransferase for dideoxy- and didehydronucleosides via a single amino acid substitution
J. Biol. Chem.
283
20053-20059
2008
Limosilactobacillus fermentum (Q6YNI5), Limosilactobacillus fermentum, Lactobacillus leichmannii (Q9RSV5), Lactobacillus leichmannii, Limosilactobacillus fermentum PAK9 (Q6YNI5)
Kaminski, P.A.; Dugue, L.; Pochet, S.
Expanding substrate specificity of nucleoside 2-deoxyribosyltransferase
Nucleic Acids Symp. Ser.
52
495-496
2008
Lactobacillus leichmannii, Limosilactobacillus fermentum (Q6YNI5)
Fernandez-Lucas, J.; Acebal, C.; Sinisterra, J.V.; Arroyo, M.; de la Mata, I.
Lactobacillus reuteri 2-deoxyribosyltransferase, a novel biocatalyst for tailoring of nucleosides
Appl. Environ. Microbiol.
76
1462-1470
2010
Limosilactobacillus reuteri (A5VK58), Limosilactobacillus reuteri
Fernandez-Lucas, J.; Fresco-Taboada, A.; Acebal, C.; de la Mata, I.; Arroyo, M.
Enzymatic synthesis of nucleoside analogues using immobilized 2-deoxyribosyltransferase from Lactobacillus reuteri
Appl. Microbiol. Biotechnol.
91
317-327
2011
Limosilactobacillus reuteri (A5VK58), Limosilactobacillus reuteri
Fernandez-Lucas, J.; Fresco-Taboada, A.; de la Mata, I.; Arroyo, M.
One-step enzymatic synthesis of nucleosides from low water-soluble purine bases in non-conventional media
Biores. Technol.
115
63-69
2012
Limosilactobacillus reuteri (A5VK58), Limosilactobacillus reuteri
Lin, Y.; Zhang, W.; Zhu, F.; Su, J.; Fang, D.; Yang, Y.; Zhang, G.; Xie, L.; Zhang, R.; Wang, H.
Subcellular localization of N-deoxyribosyltransferase in Lactobacillus fermentum: cell surface association of an intracellular nucleotide metabolic enzyme
FEMS Microbiol. Lett.
323
132-141
2011
Limosilactobacillus fermentum, Limosilactobacillus fermentum CGMCC 1.2133
Kaminski, P.A.; Labesse, G.
Phosphodeoxyribosyltransferases: designed enzymes for deoxyribonucleotide synthesis
J. Biol. Chem.
288
6534-6541
2013
Lactobacillus leichmannii (Q9R5V5)
Fresco-Taboada, A.; de la Mata, I.; Arroyo, M.; Fernandez-Lucas, J.
New insights on nucleoside 2'-deoxyribosyltransferases: a versatile biocatalyst for one-pot one-step synthesis of nucleoside analogs
Appl. Microbiol. Biotechnol.
97
3773-3785
2013
Lactococcus lactis, Lactobacillus leichmannii (Q9R5V5)
Britos, C.; Lapponi, M.; Cappa, V.; Rivero, C.; Trelles, J.
Biotransformation of halogenated nucleosides by immobilized Lactobacillus animalis 2'-N-deoxyribosyltransferase
J. Fluor. Chem.
186
91-96
2016
Ligilactobacillus animalis
-
Fernandez-Lucas, J.; Harris, R.; Mata-Casar, I.; Heras, A.; de la Mata, I.; Arroyo, M.
Magnetic chitosan beads for covalent immobilization of nucleoside 2'-deoxyribosyltransferase: application in nucleoside analogues synthesis
J. Ind. Microbiol. Biotechnol.
40
955-966
2013
Limosilactobacillus reuteri
Fresco-Taboada, A.; Serra, I.; Fernandez-Lucas, J.; Acebal, C.; Arroyo, M.; Terreni, M.; de la Mata, I.
Nucleoside 2'-deoxyribosyltransferase from psychrophilic bacterium Bacillus psychrosaccharolyticus - preparation of an immobilized biocatalyst for the enzymatic synthesis of therapeutic nucleosides
Molecules
19
11231-11249
2014
Peribacillus psychrosaccharolyticus, Peribacillus psychrosaccharolyticus CECT 4074
Vichier-Guerre, S.; Dugue, L.; Bonhomme, F.; Pochet, S.
Expedient and generic synthesis of imidazole nucleosides by enzymatic transglycosylation
Org. Biomol. Chem.
14
3638-3653
2016
Lactobacillus leichmannii
Ye, W.; Paul, D.; Gao, L.; Seckute, J.; Sangaiah, R.; Jayaraj, K.; Zhang, Z.; Kaminski, P.A.; Ealick, S.E.; Gold, A.; Ball, L.M.
Ethenoguanines undergo glycosylation by nucleoside 2'-deoxyribosyltransferases at non-natural sites
PLoS ONE
9
e115082
2014
Limosilactobacillus fermentum
Crespo, N.; Sanchez-Murcia, P.A.; Gago, F.; Cejudo-Sanches, J.; Galmes, M.A.; Fernandez-Lucas, J.; Mancheno, J.M.
2'-Deoxyribosyltransferase from Leishmania mexicana, an efficient biocatalyst for one-pot, one-step synthesis of nucleosides from poorly soluble purine bases
Appl. Microbiol. Biotechnol.
101
7187-7200
2017
Leishmania mexicana (E9AWJ0), Leishmania mexicana, Leishmania mexicana U1103 (E9AWJ0), Leishmania mexicana MHOM (E9AWJ0), Leishmania mexicana 2001 (E9AWJ0), Leishmania mexicana GT (E9AWJ0)
Del Arco, J.; Sanchez-Murcia, P.A.; Mancheno, J.M.; Gago, F.; Fernandez-Lucas, J.
Characterization of an atypical, thermostable, organic solvent- and acid-tolerant 2'-deoxyribosyltransferase from Chroococcidiopsis thermalis
Appl. Microbiol. Biotechnol.
102
6947-6957
2018
Chroococcidiopsis thermalis (K9TVX3), Chroococcidiopsis thermalis, Chroococcidiopsis thermalis PCC 7203 (K9TVX3), Chroococcidiopsis thermalis PCC 7203
Rinaldi, F.; Fernandez-Lucas, J.; de la Fuente, D.; Zheng, C.; Bavaro, T.; Peters, B.; Massolini, G.; Annunziata, F.; Conti, P.; de la Mata, I.; Terreni, M.; Calleri, E.
Immobilized enzyme reactors based on nucleoside phosphorylases and 2'-deoxyribosyltransferase for the in-flow synthesis of pharmaceutically relevant nucleoside analogues
Biores. Technol.
307
123258
2020
Limosilactobacillus reuteri (F8DQT0), Limosilactobacillus reuteri, Limosilactobacillus reuteri SD2112 (F8DQT0), Limosilactobacillus reuteri ATCC 55730 (F8DQT0)
Del Arco, J.; Mills, A.; Gago, F.; Fernandez-Lucas, J.
Structure-guided tuning of a selectivity switch towards ribonucleosides in Trypanosoma brucei purine nucleoside 2-deoxyribosyltransferase
ChemBioChem
20
2996-3000
2019
Trypanosoma brucei brucei (Q57VC7), Trypanosoma brucei brucei 927/4 GUTat10.1 (Q57VC7)
Perez, E.; Sanchez-Murcia, P.; Jordaan, J.; Blanco, M.; Mancheno, J.; Gago, F.; Fernandez-Lucas, J.
Enzymatic synthesis of therapeutic nucleosides using a highly versatile purine nucleoside 2'-deoxyribosyltransferase from Trypanosoma brucei
ChemCatChem
10
4406-4416
2018
Trypanosoma brucei brucei (Q57VC7), Trypanosoma brucei brucei 927/4 GUTat10.1 (Q57VC7)
-
Zhang, J.; Zhou, Y.; Liu, K.; Chu, J.; Zhang, Y.; He, B.
Ca2+-induced stabilization of the nucleoside 2'-deoxyribosyltransferase from Lactobacillus hilgardii ZJS01 Characteristics and application in nucleosides synthesis
Int. J. Biol. Macromol.
106
963-968
2018
Lentilactobacillus hilgardii (A0A286R847), Lentilactobacillus hilgardii, Lentilactobacillus hilgardii ZJS01 (A0A286R847)
Li, J.; Yu, L.; Li, J.; Xie, L.; Zhang, R.; Wang, H.
Establishment of a high throughput-screening system for nucleoside deoxyribosyltransferase II mutant enzymes with altered substrate specificity
J. Biosci. Bioeng.
128
22-27
2019
Lactobacillus helveticus (Q8RLY4), Lactobacillus helveticus
Mendez, M.B.; Rivero, C.W.; Lopez-Gallego, F.; Guisan, J.M.; Trelles, J.A.
Development of a high efficient biocatalyst by oriented covalent immobilization of a novel recombinant 2-N-deoxyribosyltransferase from Lactobacillus animalis
J. Biotechnol.
270
39-43
2018
Ligilactobacillus animalis, Ligilactobacillus animalis ATCC 35046
Del Arco, J.; Perona, A.; Gonzalez, L.; Fernandez-Lucas, J.; Gago, F.; Sanchez-Murcia, P.A.
Reaction mechanism of nucleoside 2-deoxyribosyltransferases free-energy landscape supports an oxocarbenium ion as the reaction intermediate
Org. Biomol. Chem.
17
7891-7899
2019
Lactobacillus leichmannii (Q9R5V5), Lactobacillus leichmannii
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