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0.017
wild-type, with 2',3'-dideoxythymidine and adenine as substrates
0.02
mutant G9S, with 2'-deoxyinosine and adenine as substrates
0.056
wild-type, with 2',3'-dideoxyuridine and cytosine as substrates
0.13
purified recombinant wild-type enzyme, pH 6.0, 37°C, substrate 2',3'-dideoxyinosine
0.19
wild-type, with 2',3'-dideoxyuridine and cytosine as substrates
0.25
mutant G9S, with 3'-dideoxythymidine and adenine as substrates
0.4
mutant G9S, with 2',3'-dideoxyguanosine and thymine as substrates
0.42
mutant A15T, 2',3'-dideoxyadenosine and thymine as substrates
0.46
mutant A15T, 2'-deoxyadenosine and thymine as substrates
0.47
mutant G9S, with 2'-deoxyinosine and adenine as substrates
0.57
mutant G9S, with 2'-deoxyguanosine and thymine
0.6
mutant G9S, with 2',3'-dideoxyguanosine and thymine as substrates
0.86
purified recombinant mutant NDT G10S, pH 6.0, 37°C, substrate 2',3'-dideoxyinosine
0.9
recombinant wild-type enzyme with substrates inosine and adenine, pH 6.0, 50°C
1.04
mutant G9S, with 2'-deoxythymidine and adenine as substrates
1.08
wild-type, with 2'-deoxyinosine and adenine as substrates
1.25
mutant G9S, with 2'-deoxycytidine and hypoxanthine as substrates
1.3
mutant G9S, with 2',3'-dideoxyuridine and cytosine as substrates
1.35
mutant A15T, 2',3'-dideoxyadenosine and cytosine as substrates
1.47
mutant A15T, 2',3'-dideoxycytidine and thymine as substrates
10.5
purified recombinant wild-type enzyme, pH 6.0, 50°C, substrates 2'-deoxyadenosine and guanine
11.1
recombinant mutant Y5F/N53D with substrates 2'-deoxyinosine and adenine, pH 4.0, 50°C
11.3
recombinant mutant Y5F with substrates 2'-deoxyinosine and adenine, pH 6.0, 50°C
11.9
wild-type, with 2'-deoxythymidine and adenine as substrates
12.3
recombinant mutant Y5F with substrates 2'-deoxyinosine and adenine, pH 4.0, 50°C
12.7
mutant G9S, with 2'-deoxyuridine and cytosine as substrates
173
wild-type, with 2'-deoxycytidine and adenine as substrates
2.7
recombinant mutant Y5F with substrates inosine and adenine, pH 6.0, 50°C
21.4
purified recombinant wild-type enzyme, pH 6.0, 50°C, substrates 2'-deoxyguanosine and adenine
27.1
mutant G9S, with 2'-deoxycytidine and adenine as substrates
29
wild-type, with 2',3'-dideoxycytidine and adenine as substrates
3.1
mutant G9S, with 2'-deoxyuridine and cytosine as substrates
3.6
wild-type, with 2'-deoxyinosine and adenine as substrates
32
wild-type, 2'-deoxycytidine and thymine as substrates
33.2
wild-type, 2'-deoxyadenosine and cytosine as substrates
36.8
-
DRTase II, reaction with thymidine + adenine
39
purified recombinant wild-type enzyme, pH 6.0, 50°C, substrates 2'-deoxyguanosine and hypoxanthine
4.95
wild-type, with 2'-deoxyguanosine and thymine
40.2
wild-type, with 2'-deoxyuridine and cytosine as substrates
42.5
wild-type, with 2'-deoxyuridine and cytosine as substrates
42.9
-
DRTase I, reaction with deoxyinosine and adenine
43
-
reaction with deoxycytidine and adenine
5.2
wild-type, with 2'-deoxyguanosine and thymine
50.3
purified recombinant mutant V11A, pH 6.0, 50°C, substrates 2'-deoxyguanosine and adenine
59.9
purified recombinant mutant V11S, pH 6.0, 50°C, substrates 2'-deoxyguanosine and adenine
6
mutant G9S, with 2',3'-dideoxycytidine and adenine as substrates
6.67
-
equals 100%, purified protein, in presence of 0.5 mg/ml bovine serum albumin, pH 7.5, 10 min, 25°C
7.11
mutant A15T, 2'-deoxycytidine and thymine as substrates
7.3
recombinant mutant Y5F/N53D with substrates 2'-deoxyinosine and adenine, pH 6.0, 50°C
7.75
-
reaction with thymidine and cytosine
8.4
wild-type, 2'-deoxyadenosine and thymine as substrates
84.7
purified recombinant mutant V11A, pH 6.0, 50°C, substrates 2'-deoxyinosine and adenine
9.5
purified recombinant wild-type enzyme, pH 6.0, 50°C, substrates 2'-deoxyadenosine and hypoxanthine
90.7
purified recombinant mutant V11S, pH 6.0, 50°C, substrates 2'-deoxyinosine and adenine
0.01
wild-type, with 2',3'-dideoxyguanosine and thymine as substrates
0.01
wild-type, with 2',3'-dideoxyinosine and adenine as substrates
0.01
wild-type, with 2',3'didehydro-2',3'-dideoxythymidine and adenine as substrates
0.01
wild-type, with 2'-deoxycytidine and hypoxanthine as substrates
0.01
wild-type, 2',3'-dideoxyadenosine and thymine as substrates
0.01
wild-type, 2',3'-dideoxycytidine and thymine as substrates
0.01
wild-type, with 2',3'-dideoxyguanosine and thymine as substrates
0.01
wild-type, with 2',3'-dideoxyinosine and adenine as substrates
0.03
wild-type, 2',3'-dideoxyadenosine and cytosine as substrates
0.03
wild-type, 2,3'-dideoxythymidine and adenine as substrates
0.03
wild-type, with 2',3'-dideoxythymidine and adenine as substrates
0.036
wild-type, 2',3'didehydro-2',3'-dideoxythymidine and adenine as substrates
0.036
wild-type, with 2',3'didehydro-2',3'-dideoxythymidine and adenine as substrates
0.04
mutant G9S, with 2',3'-dideoxyinosine and adenine as substrates
0.04
wild-type, with 2',3'-dideoxycytidine and hypoxanthine as substrates
0.05
wild-type, 2',3'-dideoxycytidine and hypoxanthine as substrates
0.05
wild-type, with 2',3'-dideoxycytidine and hypoxanthine as substrates
0.06
mutant G9S, with 2',3'-dideoxyinosine and adenine as substrates
0.06
wild-type, 2',3'-dideoxycytidine and adenine as substrates
0.06
wild-type, with 2'-deoxycytidine and hypoxanthine as substrates
0.1
below, recombinant mutant Y5F/N53D with substrates inosine and adenine, pH 4.0, 50°C
0.1
below, recombinant wild-type enzyme with substrates inosine and adenine, pH 4.0, 50°C
0.2
mutant G9S, with 2',3'didehydro-2',3'-dideoxythymidine and adenine as substrates
0.2
recombinant mutant N53D with substrates inosine and adenine, pH 6.0, 50°C
0.5
mutant A15T, 2,3'-dideoxythymidine and adenine as substrates
0.5
mutant G9S, with 3'-dideoxythymidine and adenine as substrates
0.5
recombinant mutant Y5F with substrates inosine and adenine, pH 4.0, 50°C
0.8
-
reaction with deoxyinosine and adenine
0.8
mutant G9S, with 2',3'-dideoxycytidine and hypoxanthine as substrates
1.1
mutant G9S, with 2'-deoxyguanosine and thymine
1.1
mutant A15T, 2'-deoxyadenosine and cytosine as substrates
1.29
mutant A15T, 2'-deoxycytidine and hypoxanthine as substrates
1.29
mutant G9S, with 2',3'-dideoxycytidine and adenine as substrates
1.6
mutant G9S, with 2',3'-dideoxyuridine and cytosine as substrates
1.6
recombinant mutant Y5F/N53D with substrates inosine and adenine, pH 6.0, 50°C
1.9
mutant A15T, 2'-deoxythymidine and adenine as substrates
1.9
mutant G9S, with 2'-deoxythymidine and adenine as substrates
11
purified recombinant wild-type enzyme, pH 6.0, 50°C, substrates 2'-deoxyinosine and guanine
11
recombinant mutant N53D with substrates 2'-deoxyinosine and adenine, pH 6.0, 50°C
20.1
wild-type, 2'-deoxythymidine and adenine as substrates
20.1
wild-type, with 2'-deoxythymidine and adenine as substrates
38.5
purified recombinant wild-type enzyme, pH 6.0, 50°C, substrates 2'-deoxyinosine and adenine
38.5
recombinant wild-type enzyme with substrates 2'-deoxyinosine and adenine, pH 6.0, 50°C
47.5
recombinant mutant N53D with substrates 2'-deoxyinosine and adenine, pH 4.0, 50°C
47.5
recombinant wild-type enzyme with substrates 2'-deoxyinosine and adenine, pH 4.0, 50°C
6.8
mutant A15T, 2',3'-dideoxycytidine and hypoxanthine as substrates
6.8
mutant G9S, with 2',3'-dideoxycytidine and hypoxanthine as substrates
6.9
wild-type, 2'-deoxycytidine and hypoxanthine as substrates
6.9
wild-type, with 2',3'-dideoxycytidine and adenine as substrates
7.1
mutant A15T, 2',3'-dideoxycytidine and adenine as substrates
7.1
mutant G9S, with 2'-deoxycytidine and hypoxanthine as substrates
83.7
wild-type, 2'-deoxycytidine and adenine as substrates
83.7
wild-type, with 2'-deoxycytidine and adenine as substrates
9.28
mutant A15T, 2',3'didehydro-2',3'-dideoxythymidine and adenine as substrates
9.28
mutant G9S, with 2',3'didehydro-2',3'-dideoxythymidine and adenine as substrates
9.3
mutant A15T, 2'-deoxycytidine and adenine as substrates
9.3
mutant G9S, with 2'-deoxycytidine and adenine as substrates
additional information
-
method for determining enzyme activity by coupling the release of adenine from deoxyadenosine to the reaction catalyzed by pyruvate kinase/lactate dehydrogenase via adenine phosphoribosyltransferase and adenylate kinase
additional information
-
0.9% in presence of 1 mM ZnCl2
additional information
-
102% in presence of 1 mM NaCl
additional information
-
105% in presence of 1 mM CsCl
additional information
-
106% in presence of 1 mM NaSO4
additional information
-
12.9% in presence of 1 mM CoCl2
additional information
-
143% in presence of 1 mM NH4Cl
additional information
-
151% in presence of 1 mM RbCl
additional information
-
163% in presence of 1 mM (NH4)2SO4
additional information
-
165% in presence of 1 mM K2SO4
additional information
-
166% in presence of 1 mM (NH4)2SO4 and 1 mM KCl
additional information
-
166% in presence of 1 mM KCl
additional information
-
192% in presence of 10 mM KCl
additional information
-
194% in presence of 10 mM (NH4)2SO4
additional information
-
3.2% in presence of 1 mM CuSO4
additional information
-
51.8% in presence of 1 mM CaCl2
additional information
-
66.3% in presence of 1 mM MgCl2
additional information
-
66% in presence of 1 mM MgSO4
additional information
-
68.3% in presence of 1 mM FeCl2
additional information
-
97.7% in presence of 1 mM LiCl