2.4.2.7: adenine phosphoribosyltransferase

This is an abbreviated version!
For detailed information about adenine phosphoribosyltransferase, go to the full flat file.

Reaction

Synonyms

adenine phosphoribosyl transferase, adenine phosphoribosylpyrophosphate transferase, adenine phosphoribosyltransferase, adenine phosphoribosyltransferase 2, adenione PRTase, adenosine phosphoribosyltransferase, adenylate pyrophosphorylase, adenylic pyrophosphorylase, AMP pyrophosphorylase, AMP-pyrophosphate phosphoribosyltransferase, AMP:pyrophosphate phospho-D-ribosyltransferase, APRT, APRT1, APRT2, APRTase, APRTh, apT, APT1, APT2, APT4, APT5, ApTR, FtAPRT, gpT-1, hAPRT, More, phosphoribosyltransferase, adenine, ScAPRT, SmAPRT1, Smp_054360, SSO2342, transphosphoribosidase, TtAPRT2, TTC1249, TTC1250, TTH1250, TTHA1614, TthAPRT, TthHB27APRT, TT_C1249, TT_C1250, type I PRT

ECTree

     2 Transferases

         2.4 Glycosyltransferases

             2.4.2 Pentosyltransferases

                2.4.2.7 adenine phosphoribosyltransferase

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
5	Activating Compound
33808	AA Sequence
3	Application
1	CAS Registry Number
27	Cloned(Commentary)
15	Crystallization (Commentary)
1379	Disease/ Diagnostics
9	Expression
67	General Information
11	General Stability
1	IC50 Value
121	Inhibitors
10	kcat/KM [mM/s]
36	Ki Value [mM]
94	KM Value [mM]
9	Localization
77	Metals/Ions
36	Molecular Weight [Da]
46	Natural Substrates/ Products (Substrates)
257	Organism
9	Pathway
79	PDB ID
41	pH Optimum
7	pH Range
3	pI Value
45	Protein Variants
40	Purification (Commentary)
12	Reaction
1	Reaction Type
92	Reference
55	Source Tissue
36	Specific Activity [micromol/min/mg]
13	Storage Stability
202	Substrates and Products (Substrate)
46	Subunits
146	Synonyms
1	Systematic Name
34	Temperature Optimum [°C]
1	Temperature Range [°C]
28	Temperature Stability [°C]
30	Turnover Number [1/s]

Application

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

Application on EC 2.4.2.7 - adenine phosphoribosyltransferase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide show all columns Go to Application Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

APPLICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

drug development

Leishmania tarentolae

-

the enzyme is a target for antileishmanicidal drug development

676318

medicine

Homo sapiens

-

expression of both Escherichia coli purine nucleoside phosphorylase and human adenine phosphoribosyl transferase in tumor cell lines. Purine nucleoside phosphorylase cleaves purine nucleoside analogs to generate toxic adenine analogs, which are activated by adenine phosphoribosyl transferase to metabolites that inhibit RNA and protein synthesis. In vivo studies with 6-methylpurine-2'-deoxyriboside, 2-fluoro-2'-deoxyadenosine or 9-beta-D-arabinofuranosyl-2-fluoroadenine 5'-phosphate indicate that increased adenine phosphoribosyl transferase in human tumor cells coexpressing Escherichia coli purine nucleoside phosphorylase does not enhance either the activation or the anti-tumor activity of any of the three prodrugs. Expression of excess adenine phosphoribosyl transferase in bystander cells improves the activity of 6-methylpurine-2'-deoxyriboside, but diminishes the activity of 9-beta-D-arabinofuranosyl-2-fluoroadenine 5'-phosphate. In vitro studies indicate that increasing the expression of adenine phosphoribosyl in the cells does not significantly increase the activation of 6-methylpurine

721965

synthesis

Thermus thermophilus

Q72I82

purine nucleotide synthesis using TthAPRT and TthHPRT (EC 2.4.2.8)

758715