2.4.2.8: hypoxanthine phosphoribosyltransferase

This is an abbreviated version!
For detailed information about hypoxanthine phosphoribosyltransferase, go to the full flat file.

Reaction

Synonyms

6-hydroxypurine phosphoribosyltransferase, 6-mercaptopurine phosphoribosyltransferase, 6-oxo PRTase, 6-oxopurine phosphoribosyltransferase, 6-oxopurine PRTase, Cthe_2254, EcHPRT, GMP pyrophosphorylase, GPRT, gpT-2, guanine phosphoribosyltransferase, guanine PRTase, guanine-hypoxanthine phosphoribosyltransferase, guanosine 5'-phosphate pyrophosphorylase, guanosine phosphoribosyltransferase, guanylate pyrophosphorylase, guanylic pyrophosphorylase, HGPRT, HGPRT-1, HGPRTase, HGXPRT, HGXPRTase, HG[X]PRT, HPRT, HPRT1, HPRTJerusalem, HPT, HXGPRT, hypoxanthine guanine phosphoribosyltransferase, hypoxanthine guanine xanthine phosphoribosyltransferase, hypoxanthine phosphoribosyl transferase, hypoxanthine phosphoribosyltransferase, hypoxanthine phosphoribosyltransferase 1, hypoxanthine PRTase, hypoxanthine-guanine phosphoribosyl transferase, hypoxanthine-guanine phosphoribosyltransferase, hypoxanthine-guanine phosphoribosyltransferase/adenylate kinase, hypoxanthine-guanine-(xanthine) phosphoribosyltransferase, hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine-guanine-[xanthine]-phosphoribosyltransferase, hypoxanthine-xanthine-guanine phosphoribosyltransferase, IMP pyrophosphorylase, IMP-GMP pyrophosphorylase, inosinate pyrophosphorylase, inosine 5'-phosphate pyrophosphorylase, inosine monophosphate:pyrophosphate phosphoribosyltransferase, inosinic acid pyrophosphorylase, inosinic pyrophosphorylase, More, MSMEG_6110, MtHGPRT, Pf HGXPRT, PF3D7_1012400, PfHGXPRT, PhHGXPRT, phosphoribosyltransferase, 6-mercaptopurine, phosphoribosyltransferase, hypoxanthine, PhPRT, plasma hypoxanthine-guanine phosphoribosyl transferase, PRT, purine-6-thiol phosphoribosyltransferase, PvHGPRT, SmHGPRT1, SSO2424, Tb927.10.1400, TcHPRT, transphosphoribosidase, TthHPRT, TT_C1766, ZgHGPRT/AMPK

ECTree

     2 Transferases

         2.4 Glycosyltransferases

             2.4.2 Pentosyltransferases

                2.4.2.8 hypoxanthine phosphoribosyltransferase

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Results	in table
11	Activating Compound
30876	AA Sequence
39	Application
1	CAS Registry Number
54	Cloned(Commentary)
24	Crystallization (Commentary)
4142	Disease/ Diagnostics
1	Expression
61	General Information
7	General Stability
299	Inhibitors
54	kcat/KM [mM/s]
152	Ki Value [mM]
274	KM Value [mM]
22	Localization
68	Metals/Ions
53	Molecular Weight [Da]
161	Natural Substrates/ Products (Substrates)
531	Organism
10	Pathway
262	PDB ID
71	pH Optimum
9	pH Range
4	pH Stability
2	Posttranslational Modification
111	Protein Variants
63	Purification (Commentary)
35	Reaction
2	Reaction Type
147	Reference
1	Renatured (Commentary)
60	Source Tissue
77	Specific Activity [micromol/min/mg]
14	Storage Stability
394	Substrates and Products (Substrate)
81	Subunits
246	Synonyms
1	Systematic Name
42	Temperature Optimum [°C]
1	Temperature Range [°C]
16	Temperature Stability [°C]
182	Turnover Number [1/s]

Activating Compound

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Activating Compound on EC 2.4.2.8 - hypoxanthine phosphoribosyltransferase

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ACTIVATING COMPOUND

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

acetate

2 entries

GMP

Methanococcus voltae

-

0.05 mM, at least 2fold stimulation, hypoxanthine phosphoribosyltransferase activity

727728

IMP

4 entries

phosphate

Mycobacterium tuberculosis

P9WHQ9

the tetrameric enzyme activity increases in phosphate buffer, while the dimeric state, which occurs when excess magnesium ions are removed, is unable to be rapidly activated by phosphate and magnesium. Phosphate alone cannot activate the enzyme, magnesium ions are also required

758862

additional information

4 entries

-

acetate

Escherichia coli

-

slightly activating

638391

acetate

Salmonella enterica subsp. enterica serovar Typhimurium

-

slightly activating

638391

IMP

Methanococcus voltae

-

0.2 mM, at least 2fold stimulation, hypoxanthine phosphoribosyltransferase activity

727728

IMP

Plasmodium falciparum

P20035

-

736777

IMP

Plasmodium falciparum

P20035

activation with IMP results primarily in an increase in kcat, which is 3-5fold in the case of hypoxanthine and xanthine phosphoribosylation and more than 10fold in the case of guanine phosphoribosylation

736785

IMP

Plasmodium falciparum

Q8IJS1

activates the enzyme, activating effects on wild-type and mutant enzymes, overview. Upon activation of the mutants with IMP, the lag phase disappears, while an increase in the specific activity values appears. Although activation of wild-type and mutants by IMP increases their catalytic efficiency by about 100fold, it is found that the kcat/Km values for the mutants drop by 5.7 to 75fold when compared with the wild-type enzyme

760104

additional information

Methanococcus voltae

-

hypoxanthine phosphoribosyltransferase activity is unaffected by AMP

727728

-

additional information

Plasmodium falciparum

-

activation by substrate and product IMP, reversibly destabilizes the enzyme

661691

-

additional information

Plasmodium falciparum

P20035

not activated by GMP or XMP

736785

-

additional information

Plasmodium falciparum

-

not activated by GMP or XMP

736785

-