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2.4.2.8: hypoxanthine phosphoribosyltransferase

This is an abbreviated version!
For detailed information about hypoxanthine phosphoribosyltransferase, go to the full flat file.

Word Map on EC 2.4.2.8

Reaction

IMP
+
diphosphate
=
hypoxanthine
 +
5-phospho-alpha-D-ribose 1-diphosphate

Synonyms

6-hydroxypurine phosphoribosyltransferase, 6-mercaptopurine phosphoribosyltransferase, 6-oxo PRTase, 6-oxopurine phosphoribosyltransferase, 6-oxopurine PRTase, Cthe_2254, EcHPRT, GMP pyrophosphorylase, GPRT, gpT-2, guanine phosphoribosyltransferase, guanine PRTase, guanine-hypoxanthine phosphoribosyltransferase, guanosine 5'-phosphate pyrophosphorylase, guanosine phosphoribosyltransferase, guanylate pyrophosphorylase, guanylic pyrophosphorylase, HGPRT, HGPRT-1, HGPRTase, HGXPRT, HGXPRTase, HG[X]PRT, HPRT, HPRT1, HPRTJerusalem, HPT, HXGPRT, hypoxanthine guanine phosphoribosyltransferase, hypoxanthine guanine xanthine phosphoribosyltransferase, hypoxanthine phosphoribosyl transferase, hypoxanthine phosphoribosyltransferase, hypoxanthine phosphoribosyltransferase 1, hypoxanthine PRTase, hypoxanthine-guanine phosphoribosyl transferase, hypoxanthine-guanine phosphoribosyltransferase, hypoxanthine-guanine phosphoribosyltransferase/adenylate kinase, hypoxanthine-guanine-(xanthine) phosphoribosyltransferase, hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine-guanine-[xanthine]-phosphoribosyltransferase, hypoxanthine-xanthine-guanine phosphoribosyltransferase, IMP pyrophosphorylase, IMP-GMP pyrophosphorylase, inosinate pyrophosphorylase, inosine 5'-phosphate pyrophosphorylase, inosine monophosphate:pyrophosphate phosphoribosyltransferase, inosinic acid pyrophosphorylase, inosinic pyrophosphorylase, More, MSMEG_6110, MtHGPRT, Pf HGXPRT, PF3D7_1012400, PfHGXPRT, PhHGXPRT, phosphoribosyltransferase, 6-mercaptopurine, phosphoribosyltransferase, hypoxanthine, PhPRT, plasma hypoxanthine-guanine phosphoribosyl transferase, PRT, purine-6-thiol phosphoribosyltransferase, PvHGPRT, SmHGPRT1, SSO2424, Tb927.10.1400, TcHPRT, transphosphoribosidase, TthHPRT, TT_C1766, ZgHGPRT/AMPK

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.2 Pentosyltransferases
                2.4.2.8 hypoxanthine phosphoribosyltransferase

KI Value

KI Value on EC 2.4.2.8 - hypoxanthine phosphoribosyltransferase

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.037
(2-[(2,3-dihydroxypropyl)[2-(6-oxo-1,6-dihydro-9H-purin-9-yl)ethyl]amino]ethyl)phosphonic acid
0.1 M Tris-HCl, 12 mM MgCl2, pH 7.4, 25°C
0.000008 - 0.00006
(2-[(3R,4R)-3-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-[(2R)-2-hydroxy-2-phosphonoethoxy]pyrrolidin-1-yl]-2-oxoethyl)phosphonic acid
0.000014 - 0.00008
(2-[[(3R,4R)-4-(6-oxo-1,6-dihydro-9H-purin-9-yl)-1-(phosphonoacetyl)pyrrolidin-3-yl]oxy]ethyl)phosphonic acid
0.0014
(2-[[2-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)ethyl][2-(2-phosphonoethoxy)ethyl]amino]ethyl)phosphonic acid
0.1 M Tris-HCl, 12 mM MgCl2, pH 7.4, 25°C
0.00049 - 0.01
(3-hydroxy-2-[[([4-hydroxy-5H-pyrrolo[3,2-d]pyrimidin-7-yl]methyl)amino]methyl]propyl)phosphonic acid
0.00001
(3-[[(4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]propyl)phosphonic acid
-
pH 7.6, 37°C
0.02 - 0.041
(R)-9-[2-(phosphonomethoxy)propyl]-8-bromoguanine
0.4373
(R)-9-[2-(phosphonomethoxy)propyl]hypoxanthine
-
pH 8.5, 25°C
0.0006 - 0.0059
(R,S)-9-[3-hydroxy-2-(phosphonomethoxy)propyl]guanine
0.0004 - 0.073
(S)-3-(guanin-9-yl)-pyrrolidin-N-ylacetylphosphonic acid
0.015 - 0.045
(S)-9-[2-(phosphonomethoxy)propyl]-8-azaguanine
0.011 - 0.3
(S)-9-[2-(phosphonomethoxy)propyl]-8-bromoguanine
0.0648 - 0.1823
(S)-9-[2-(phosphonomethoxy)propyl]hypoxanthine
0.0284 - 0.1768
(S)-9-[3-hydroxy-2-(phosphonomethoxy)propyl]guanine
0.0000276 - 0.01
3-((7-hydroxy-1H-pyrazolo[4,3-d]pyrimidin-3-yl)methylamino)propylphosphonate
0.037 - 0.423
5-phospho-alpha-D-ribose 1-diphosphate
0.5 - 1
6-methylheptyl hydrogen {[2-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)ethoxy]methyl}phosphonate
0.0008
6-thioguanine
-
-
0.0134
9-[(N-phosphonoethyl-N-phosphonobutyl)-2-aminoethyl]hypoxanthine
0.1 M Tris-HCl, 12 mM MgCl2, pH 7.4, 25°C
0.00075
9-[(N-phosphonoethyl-N-phosphonoethoxyethyl)-2-aminoethyl]-hypoxanthine
0.1 M Tris-HCl, 12 mM MgCl2, pH 7.4, 25°C
0.00167
9-[(N-phosphonoethyl-N-phosphonomethoxyethyl)-2-aminoethyl]hypoxanthine
0.1 M Tris-HCl, 12 mM MgCl2, pH 7.4, 25°C
0.0218
9-[(N-phosphonoethyl-N-phosphonomethyl)-2-aminoethyl]-hypoxanthine
0.1 M Tris-HCl, 12 mM MgCl2, pH 7.4, 25°C
0.0001 - 0.001
9-[2-(2-phosphonoethoxy)ethyl]guanine
0.0003 - 0.0036
9-[2-(2-phosphonoethoxy)ethyl]hypoxanthine
0.0036 - 0.0227
9-[2-(phosphonomethoxy)-3-fluoro-propyl]guanine
0.1 - 1
9-[2-(phosphonomethoxy)ethyl]-6-thioguanine
0.0043 - 0.0072
9-[2-(phosphonomethoxy)ethyl]-7-deaza-8-azahypoxanthine
0.003 - 0.175
9-[2-(phosphonomethoxy)ethyl]-8-azaguanine
0.01 - 0.4
9-[2-(phosphonomethoxy)ethyl]-8-bromoguanine
0.0016 - 0.0559
9-[2-(phosphonomethoxy)ethyl]guanine
0.0012 - 0.068
9-[2-(phosphonomethoxy)ethy]-8-hydroxyguanine
0.14
adenine
-
-
0.0254
ADP
-
mutant K134S, competitive versus 5-phospho-alpha-D-ribose 1-diphosphate
0.001 - 0.019
cyclic (R)-9-[3-hydroxy-2-(phosphonomethoxy)propyl]guanine
0.008 - 0.1151
cyclic (S)-9-[3-hydroxy-2-(phosphonomethoxy)propyl]guanine
0.093 - 0.302
diphosphate
0.02 - 0.526
GMP
0.004 - 0.018
guanine
0.0058 - 0.01
guanine ribose 5'-phosphate
0.023 - 0.08
hypoxanthine
0.0036 - 0.0054
hypoxanthine ribose 5'-phosphate
0.037 - 0.247
IMP
0.017
monophosphonate-2-(phosphonoethoxy)ethyl hypoxanthine
pH and temperature not specified in the publication
0.14 - 0.2
propan-2-yl hydrogen {[2-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)ethoxy]methyl}phosphonate
0.14
xanthine
-
-
0.000019 - 0.01
[(+/-)-2(R/S)-3-hydroxy-2-[([4-hydroxy-5H-pyrrolo[3,2-d]pyrimidin-7-yl]methyl)amino]propoxy]phosphonic acid
0.0094 - 0.01
[(+/-)-2(R/S)-[([2-chloro-4-hydroxy-5H-pyrrolo[3,2-d]pyrimidin-7-yl]methyl)amino]-3-hydroxypropoxy]phosphonic acid
0.0000013 - 0.000006
[(1S)-1-hydroxy-2-[[(3R,4R)-4-(6-oxo-1,6-dihydro-9H-purin-9-yl)-1-(phosphonoacetyl)pyrrolidin-3-yl]oxy]ethyl]phosphonic acid
0.0000143 - 0.01
[(2R)-2-[([2-amino-4-hydroxy-5H-pyrrolo[3,2-d]pyrimidin-7-yl]methyl)amino]-3-hydroxypropoxy]phosphonic acid
0.0000024 - 0.01
[(2R)-3-hydroxy-2-[([4-hydroxy-5H-pyrrolo[3,2-d]pyrimidin-7-yl]methyl)amino]propoxy]phosphonic acid
0.00065 - 0.01
[(2S)-2-[([2-amino-4-hydroxy-5H-pyrrolo[3,2-d]pyrimidin-7-yl]methyl)amino]-3-hydroxypropoxy]phosphonic acid
0.00098 - 0.01
[(2S,3R)-2,4-dihydroxy-3-[([4-hydroxy-5H-pyrrolo[3,2-d]pyrimidin-7-yl]methyl)amino]butoxy]phosphonic acid
0.0000012 - 0.042
[(3R)-4-hydroxy-3-[([4-hydroxy-5H-pyrrolo[3,2-d]pyrimidin-7-yl]methyl)amino]butyl]phosphonic acid
0.000087 - 0.01
[(3S)-1,1-difluoro-4-hydroxy-3-[([4-hydroxy-5H-pyrrolo[3,2-d]pyrimidin-7-yl]methyl)amino]butyl]phosphonic acid
0.0001 - 0.01
[(3S)-3-[([2-amino-4-hydroxy-5H-pyrrolo[3,2-d]pyrimidin-7-yl]methyl)amino]-1,1-difluoro-4-hydroxybutyl]phosphonic acid
0.00000065 - 0.00038
[(3S)-4-hydroxy-3-[([4-hydroxy-5H-pyrrolo[3,2-d]pyrimidin-7-yl]methyl)amino]butyl]phosphonic acid
0.00000065
[(3S)-4-hydroxy-3-[[(4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]butyl]phosphonic acid
-
pH 7.6, 37°C
0.0000091 - 0.01
[2-hydroxy-3-[([4-hydroxy-5H-pyrrolo[3,2-d]pyrimidin-7-yl]methyl)amino]propyl] phosphonic acid
0.00062 - 0.01
[2-[(2-[4-hydroxy-5H-pyrrolo[3,2-d]pyrimidin-7-yl]ethyl)amino]ethyl]phosphonic acid
0.01 - 0.0144
[2-[([4-hydroxy-5H-pyrrolo[3,2-d]pyrimidin-7-yl]methyl)amino]ethoxy]phosphonic acid
0.000006 - 0.00007
[3-(guanine-9-yl)-2-((2-phosphonoethoxy)methyl)propoxy]methylphosphonic acid
0.01 - 0.0153
[3-hydroxy-2-[([4-hydroxy-5H-pyrrolo[3,2-d]pyrimidin-7-yl]methyl)amino]-2-(hydroxymethyl)propoxy]phosphonic acid
0.01132 - 0.02
[3-[(2-[4-hydroxy-5H-pyrrolo[3,2-d]pyrimidin-7-yl]ethyl)amino]propyl]phosphonic acid
0.000003 - 0.00002
[3R,4R]-4-guanin-9-yl-3-((S)-2-hydroxy-2-phosphonoethyl)oxy-1-N-(phosphonopropionyl)pyrrolidine
0.00049 - 0.01
[[([4-hydroxy-5H-pyrrolo[3,2-d]pyrimidin-7-yl]methyl)amino]butyl]phosphonic acid
0.0019 - 0.01
[[([4-hydroxy-5H-pyrrolo[3,2-d]pyrimidin-7-yl]methyl)amino]ethyl]phosphonic acid
0.01 - 0.02
[[([4-hydroxy-5H-pyrrolo[3,2-d]pyrimidin-7-yl]methyl)amino]methyl]phosphonic acid
0.0086 - 0.01
[[([4-hydroxy-5H-pyrrolo[3,2-d]pyrimidin-7-yl]methyl)amino]pentyl]phosphonic acid
0.0000106 - 0.0049
[[([4-hydroxy-5H-pyrrolo[3,2-d]pyrimidin-7-yl]methyl)amino]propyl]phosphonic acid
0.0008
[[2-[(6-oxo-1,6-dihydro-9H-purin-9-yl)methyl]propane-1,3-diyl]bis(oxymethylene)]bis(phosphonic acid)
0.1 M Tris-HCl, 12 mM MgCl2, pH 7.4, 25°C
0.0028
[[[(4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]azanediyl]di(propane-3,1-diyl)]bis(phosphonic acid)
0.1 M Tris-HCl, 12 mM MgCl2, pH 7.4, 25°C
additional information
additional information
-