2.4.2.9: uracil phosphoribosyltransferase

This is an abbreviated version!
For detailed information about uracil phosphoribosyltransferase, go to the full flat file.

Word Map on EC 2.4.2.9

2.4.2.9

5-fluorouracil

pyrimidine

salvage

5-fluorocytosine

suicide

prodrug

orotate

bystander

5-fluorouridine

oncolytic

markerless

phosphoribosyltransferases

counterselectable

flucytosine

4-thiouracil

medicine

virotherapy

cd/5-fc

gene-directed

synthesis

analysis

molecular biology

pharmacology

Reaction

Synonyms

AFR052C, AFR052Cp, AGOS_AFR052C, AgUPRT, CD-UPRT, cytosine deaminase-uracil phosphoribosyltransferase, cytosine deaminase/uracil phosphoribosyltransferase, More, MtUPRT, phosphoribosyltransferase, uracil, Rv3309c, TtUPRT, TtUPRT3, UK/UPRT1, UMP pyrophosphorylase, UMP:pyrophosphate phosphoribosyltransferase, UPP, UPRT, UPRTase, uracil phosphoribosyl transferase, uridine 5'-phosphate pyrophosphorylase, uridine kinase-like protein (uracil phosphoribosyltransferase), uridine kinase/uracil phosphoribosyltransferase 1, uridine monophosphate pyrophosphorylase, uridylate pyrophosphorylase, uridylic pyrophosphorylase

ECTree

2 Transferases

2.4 Glycosyltransferases

2.4.2 Pentosyltransferases

2.4.2.9 uracil phosphoribosyltransferase

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Results	in table
22	Activating Compound
44618	AA Sequence
15	Application
1	CAS Registry Number
34	Cloned(Commentary)
7	Crystallization (Commentary)
312	Disease/ Diagnostics
24	General Information
10	General Stability
1	IC50 Value
49	Inhibitors
5	Ki Value [mM]
46	KM Value [mM]
4	Localization
43	Metals/Ions
33	Molecular Weight [Da]
32	Natural Substrates/ Products (Substrates)
368	Organism
5	Pathway
104	PDB ID
21	pH Optimum
7	pH Range
2	pI Value
20	Protein Variants
21	Purification (Commentary)
10	Reaction
1	Reaction Type
66	Reference
30	Source Tissue
19	Specific Activity [micromol/min/mg]
12	Storage Stability
109	Substrates and Products (Substrate)
36	Subunits
88	Synonyms
1	Systematic Name
16	Temperature Optimum [°C]
2	Temperature Range [°C]
14	Temperature Stability [°C]
8	Turnover Number [1/s]

Application

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Application on EC 2.4.2.9 - uracil phosphoribosyltransferase

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analysis

Toxoplasma gondii

biosynthetic labeling of RNA with uracil phosphoribosyltransferase allows cell-specific microarray analysis of mRNA synthesis and decay

medicine

molecular biology

engineering the yeast fluorocytosine deaminase (FCY1) gene by creating a fusion with the bacterial uracil phosphoribosyl transferase (UPP) gene results in a recombinant protein that converts the precursor 5-fluorocytosine (5-FC) into 5-fluorouracyl, a drug used in the treatment of a range of cancers, which triggers DNA and RNA damage. The tissue-specific FCY-UPP system is a great tool to inactivate cells in a precise spatial and temporal manner, method evaluation, overview

755036

pharmacology

[Bacillus] caldolyticus

P70881

potential target for the development of new antibiotics

638375

synthesis

Thermus thermophilus

Q5SIQ7

MtTtUPRT is successfully applied in the enzymatic synthesis of therapeutic NMP analogues. The immobilized enzyme is usable as a biocatalyst in the synthesis of different 5-modified uridine-5'-monophosphates at short times. MTtUPRT3 can be reused up to 8 times in the synthesis of uridine-5'-monophosphate (UMP) with maximum activity at 100°C and pH 7.0 (activity 968 IU/g support, retaining activity 100%). Potential application of MTtUPRT3 as industrial biocatalyst

758849

additional information

4 entries