2.4.99.12: lipid IVA 3-deoxy-D-manno-octulosonic acid transferase

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For detailed information about lipid IVA 3-deoxy-D-manno-octulosonic acid transferase, go to the full flat file.

Reaction

Synonyms

3-deoxy-D-manno-2-octulosonic acid transferase, 3-deoxy-D-manno-oct-2-ulosonic acid transferase, 3-deoxy-D-manno-oct-2-ulosonic acid transferases, 3-deoxy-D-manno-octulosonic acid transferase, 3-deoxy-manno-octulosonic acid transferase, beta-Kdo transferase, Kdo transferase, KdtA, KpsC, KpsS, LipA, LipB, mono-functional Kdo transferase, monofunctional KDO transferase, multi-functional Kdo-transferase, WaaA, WaaAAAE

ECTree

     2 Transferases

         2.4 Glycosyltransferases

             2.4.99 Transferring other glycosyl groups

                2.4.99.12 lipid IVA 3-deoxy-D-manno-octulosonic acid transferase

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Results	in table
1	Activating Compound
24593	AA Sequence
12	Cloned(Commentary)
1	Crystallization (Commentary)
2	Expression
10	General Information
3	Inhibitors
2	KM Value [mM]
2	Localization
1	Metals/Ions
4	Molecular Weight [Da]
10	Natural Substrates/ Products (Substrates)
29	Organism
12	Pathway
3	pH Optimum
1	pH Range
4	Protein Variants
5	Purification (Commentary)
2	Reaction
27	Reference
3	Source Tissue
1	Specific Activity [micromol/min/mg]
24	Substrates and Products (Substrate)
5	Subunits
52	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
3	Temperature Stability [°C]

Systematic Name

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Systematic Name on EC 2.4.99.12 - lipid IVA 3-deoxy-D-manno-octulosonic acid transferase

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SYSTEMATIC NAME

IUBMB Comments

CMP-3-deoxy-D-manno-oct-2-ulosonate:lipid IVA 3-deoxy-D-manno-oct-2-ulosonate transferase

The enzyme from Escherichia coli is bifunctional and transfers two 3-deoxy-D-manno-oct-2-ulosonate residues to lipid IVA (cf. EC 2.4.99.13 [(Kdo)-lipid IVA 3-deoxy-D-manno-octulosonic acid transferase]) [1]. The monofunctional enzymes from Bordetella pertusis, Aquifex aeolicus and Haemophilus influenzae catalyse the transfer of a single 3-deoxy-D-manno-oct-2-ulosonate residue from CMP-3-deoxy-D-manno-oct-2-ulosonate to lipid IVA [2-4]. The enzymes from Chlamydia transfer three or more 3-deoxy-D-manno-oct-2-ulosonate residues and generate genus-specific epitopes [5].