2.4.99.16: starch synthase (maltosyl-transferring)
This is an abbreviated version!
For detailed information about starch synthase (maltosyl-transferring), go to the full flat file.
Word Map on EC 2.4.99.16
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2.4.99.16
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tuberculosis
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glycogen
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coelicolor
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trehalose
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cyclodextrins
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maltooligosaccharides
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antituberculosis
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venezuelae
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actinomycetes
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disaccharide
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glycogen-like
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capsular
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smegmatis
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drug development
- 2.4.99.16
- tuberculosis
- glycogen
- coelicolor
- trehalose
- cyclodextrins
- maltooligosaccharides
-
antituberculosis
- venezuelae
- actinomycetes
- disaccharide
-
glycogen-like
-
capsular
- smegmatis
- drug development
Reaction
Synonyms
alpha-maltose 1-phosphate:(1->4)-alpha-D-glucan 4-alpha-D-maltosyltransferase, alpha1,4-glucan:maltose-1-P maltosyltransferase, GlgE, GlgE isoform I, GMPMT, maltosyl transferase, maltosyltransferase, maltosyltransferase GlgE
ECTree
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General Information
General Information on EC 2.4.99.16 - starch synthase (maltosyl-transferring)
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drug target
malfunction
metabolism
the enzyme has been genetically validated as a target for tuberculosis therapies
drug target
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the enzyme has been genetically validated as a target for tuberculosis therapies
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a constructed DELTAglgE null mutant strain was viable but shows a delayed developmental phenotype when grown on maltose, giving less cell mass and delayed sporulation. Pre-spore cells and spores of the mutant are frequently double the length of those of the wild-type, implying impaired cross-wall formation, and spores show reduced tolerance to stress. The mutant accumulates alpha-maltose 1-phosphate and maltose but no alpha-glucan
malfunction
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a constructed DELTAglgE null mutant strain was viable but shows a delayed developmental phenotype when grown on maltose, giving less cell mass and delayed sporulation. Pre-spore cells and spores of the mutant are frequently double the length of those of the wild-type, implying impaired cross-wall formation, and spores show reduced tolerance to stress. The mutant accumulates alpha-maltose 1-phosphate and maltose but no alpha-glucan
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the enzyme catalyzes the last step in the conversion of trehalose to glycogen transfering maltose from maltose 1-phosphate to glycogen. Trehalose synthase, maltokinase, and GMPMT represent an additional pathway of glycogen synthesis using trehalose as the source of glucose
metabolism
the enzyme is involved inx02alpha-glucan biosynthesis in bacteria
metabolism
the following assembly mechanism is proposed. Polymer synthesis starts with GlgE and its donor substrate, alpha-maltose 1-phosphate, yielding a linear oligomer with a degree of polymerization (of about 16) sufficient for GlgB to introduce a branch. Branching involves strictly intrachain transfer to generate a C chain (the only constituent chain to retain its reducing end), which now bears an A chain (a nonreducing end terminal branch that does not itself bear a branch). GlgE preferentially extends A chains allowing GlgB to act iteratively to generate new A chains emanating from B chains (nonterminal branches that themselves bear a branch). Although extension and branching occur primarily with A chains, the other chain types are sometimes extended and branched such that some B chains (and possibly C chains) bear more than one branch
metabolism
the following assembly mechanism is proposed. Polymer synthesis starts with GlgE and its donor substrate, alpha-maltose 1-phosphate, yielding a linear oligomer with a degree of polymerization (of about 16) sufficient for GlgB to introduce a branch. Branching involves strictly intrachain transfer to generate a C chain (the only constituent chain to retain its reducing end), which now bears an A chain (a nonreducing end terminal branch that does not itself bear a branch). GlgE preferentially extends A chains allowing GlgB to act iteratively to generate new A chains emanating from B chains (nonterminal branches that themselves bear a branch). Although extension and branching occur primarily with A chains, the other chain types are sometimes extended and branched such that some B chains (and possibly C chains) bear more than one branch
metabolism
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the enzyme catalyzes the last step in the conversion of trehalose to glycogen transfering maltose from maltose 1-phosphate to glycogen. Trehalose synthase, maltokinase, and GMPMT represent an additional pathway of glycogen synthesis using trehalose as the source of glucose
-
metabolism
-
the following assembly mechanism is proposed. Polymer synthesis starts with GlgE and its donor substrate, alpha-maltose 1-phosphate, yielding a linear oligomer with a degree of polymerization (of about 16) sufficient for GlgB to introduce a branch. Branching involves strictly intrachain transfer to generate a C chain (the only constituent chain to retain its reducing end), which now bears an A chain (a nonreducing end terminal branch that does not itself bear a branch). GlgE preferentially extends A chains allowing GlgB to act iteratively to generate new A chains emanating from B chains (nonterminal branches that themselves bear a branch). Although extension and branching occur primarily with A chains, the other chain types are sometimes extended and branched such that some B chains (and possibly C chains) bear more than one branch
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metabolism
-
the enzyme is involved inx02alpha-glucan biosynthesis in bacteria
-
metabolism
-
the following assembly mechanism is proposed. Polymer synthesis starts with GlgE and its donor substrate, alpha-maltose 1-phosphate, yielding a linear oligomer with a degree of polymerization (of about 16) sufficient for GlgB to introduce a branch. Branching involves strictly intrachain transfer to generate a C chain (the only constituent chain to retain its reducing end), which now bears an A chain (a nonreducing end terminal branch that does not itself bear a branch). GlgE preferentially extends A chains allowing GlgB to act iteratively to generate new A chains emanating from B chains (nonterminal branches that themselves bear a branch). Although extension and branching occur primarily with A chains, the other chain types are sometimes extended and branched such that some B chains (and possibly C chains) bear more than one branch
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