2.4.99.17: S-adenosylmethionine:tRNA ribosyltransferase-isomerase

This is an abbreviated version!
For detailed information about S-adenosylmethionine:tRNA ribosyltransferase-isomerase, go to the full flat file.

Reaction

Synonyms

QueA, QueA enzyme, queuosine biosynthesis protein, queuosine biosynthesis protein QueA, S-adenosylmethionine:tRNA ribosyltransferase-isomerase, TM0574

ECTree

     2 Transferases

         2.4 Glycosyltransferases

             2.4.99 Transferring other glycosyl groups

                2.4.99.17 S-adenosylmethionine:tRNA ribosyltransferase-isomerase

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Results	in table
4	Activating Compound
32087	AA Sequence
1	CAS Registry Number
3	Cloned(Commentary)
2	Cofactor
2	Crystallization (Commentary)
2	General Information
1	General Stability
17	Inhibitors
2	kcat/KM [mM/s]
4	Ki Value [mM]
5	KM Value [mM]
4	Molecular Weight [Da]
1	Natural Substrates/ Products (Substrates)
8	Organism
2	Pathway
2	pH Optimum
1	pI Value
6	Purification (Commentary)
1	Reaction
8	Reference
9	Substrates and Products (Substrate)
3	Subunits
19	Synonyms
1	Systematic Name
3	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 2.4.99.17 - S-adenosylmethionine:tRNA ribosyltransferase-isomerase

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INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

adenine

Escherichia coli

-

noncompetitive inhibition against S-adenosyl-L-methionine and 7-(aminomethyl)-7-deazaguanine-tRNATyr

718836

CaCl2

Escherichia coli

-

43% residual activity at 10 mM

719812

epoxyqueuosine-tRNATyr

Escherichia coli

-

competitive inhibition against 7-(aminomethyl)-7-deazaguanine-tRNATyr and noncompetitive inhibition against S-adenosyl-L-methionine

718836

KCl

Escherichia coli

-

28% residual activity at 100 mM

719812

L-methionine

Escherichia coli

-

uncompetitive inhibition versus 7-(aminomethyl)-7-deazaguanine-tRNATyr and noncompetitive inhibition against S-adenosyl-L-methionine

718836

Mg2+

2 entries

Mn2+

2 entries

Na2PO4

Escherichia coli

-

80% residual activity at 25 mM

719812

Na2SO4

Escherichia coli

-

33% residual activity at 25 mM

719812

NaCl

Escherichia coli

-

25% residual activity at 100 mM

719812

NaSCN

Escherichia coli

-

60% residual activity at 0.01 mM

719812

potassium fluoride

Escherichia coli

-

78% residual activity at 500 mM

719812

S-adenosylhomocysteine

Escherichia coli

-

competitive inhibition against S-adenosyl-L-methionine and noncompetitive inhibition against 7-(aminomethyl)-7-deazaguanine-tRNATyr

718836

sinefungin

Escherichia coli

-

competitive inhibition against S-adenosyl-L-methionine and noncompetitive inhibition against 7-(aminomethyl)-7-deazaguanine-tRNATyr

718836

Tris-HCl

Escherichia coli

-

11% residual activity at 100 mM

719812

Mg2+

Bacillus subtilis

O32054

millimolar inhibitor

718731

Mg2+

Escherichia coli

-

Mg2+ in millimolar concentrations inhibits enzyme activity but has little or no effect in the submillimolar range

719812

Mn2+

Bacillus subtilis

O32054

millimolar inhibitor

718731

Mn2+

Escherichia coli

-

Mn2+ in millimolar concentrations inhibits enzyme activity but has little or no effect in the submillimolar range

719812