2.4.99.20: 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase

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For detailed information about 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase, go to the full flat file.

Reaction

Synonyms

2'-phospho-cyclic-ADP-ribose transferase, ADP-ribosyl cyclase 1, ADPRC 1, BST1, CD38, diphosphopyridine nucleosidase

ECTree

     2 Transferases

         2.4 Glycosyltransferases

             2.4.99 Transferring other glycosyl groups

                2.4.99.20 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase

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Results	in table
639	AA Sequence
1	Cloned(Commentary)
2	Crystallization (Commentary)
1	Expression
7	General Information
5	IC50 Value
6	Inhibitors
3	KM Value [mM]
7	Localization
2	Natural Substrates/ Products (Substrates)
15	Organism
1	Pathway
12	PDB ID
1	pH Optimum
6	Protein Variants
6	Reaction
15	Reference
8	Source Tissue
4	Specific Activity [micromol/min/mg]
33	Substrates and Products (Substrate)
14	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]

Inhibitors

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Inhibitors on EC 2.4.99.20 - 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase

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INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

Cu2+

Oryctolagus cuniculus

-

-

726898

NAD+

Oryctolagus cuniculus

-

-

726898

NADP+

Oryctolagus cuniculus

-

-

726898

nicotinamide

Oryctolagus cuniculus

-

inhibition of the cyclization reaction and is 30fold more potent at suppressing the base-exchange reaction. Inhibition is not via a competition with the nicotinic acid-binding site

726898

Zn2+

Oryctolagus cuniculus

-

-

726898

additional information

Oryctolagus cuniculus

-

the cyclization reaction is insensitive to free Ca2+ concentration in the range 20 nM–100 microM. Mg2+ is not inhibitory

726898

-