2.5.1.1: dimethylallyltranstransferase
This is an abbreviated version!
For detailed information about dimethylallyltranstransferase, go to the full flat file.
Word Map on EC 2.5.1.1
-
2.5.1.1
-
farnesyl
-
monoterpene
-
prenyltransferases
-
terpenoids
-
ggpps
-
prenylation
-
geraniol
-
aspartate-rich
-
dmapp
-
tryptophan-containing
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myrcene
-
carotenogenic
-
1-deoxy-d-xylulose-5-phosphate
-
uredovora
-
neosartorya
-
spearmint
-
oleoresin
- 2.5.1.1
-
farnesyl
-
monoterpene
- prenyltransferases
-
terpenoids
- ggpps
-
prenylation
- geraniol
-
aspartate-rich
-
dmapp
-
tryptophan-containing
- myrcene
-
carotenogenic
- 1-deoxy-d-xylulose-5-phosphate
- uredovora
-
neosartorya
- spearmint
-
oleoresin
Reaction
Synonyms
(E)-geranyl diphosphate synthase, AnaPT, At4g36810, dimethylallyl transferase, ERG20, farnesyl diphosphate synthase, FgaPT2, FPPase, FPPS, FPPS2, geranyl diphosphate synthase, geranyl pyrophosphate synthase, geranylgeranyl pyrophosphate synthase, GGPPS11, GPP (C5) synthase, GPP synthase, GPP/FPP synthase, GPPS, HpGGPPS, IDS, IDS1, IDS2, IdsA, isoprenyl diphosphate synthase, PcIDS1, Rv0989c
ECTree
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Reference on EC 2.5.1.1 - dimethylallyltranstransferase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Vandermoten, S.; Santini, S.; Haubruge, E.; Heuze, F.; Francis, F.; Brasseur, R.; Cusson, M.; Charloteaux, B.
Structural features conferring dual geranyl/farnesyl diphosphate synthase activity to an aphid prenyltransferase
Insect Biochem. Mol. Biol.
39
707-716
2009
Acyrthosiphon pisum (Q1X877)
Lewis, M.J.; Prosser, I.M.; Mohib, A.; Field, L.M.
Cloning and characterisation of a prenyltransferase from the aphid Myzus persicae with potential involvement in alarm pheromone biosynthesis
Insect Mol. Biol.
17
437-443
2008
Myzus persicae (Q1X876), Myzus persicae
Nagaki, M.; Musashi, T.; Hirano, Y.; Tanaka, H.; Ichita, J.; Maki, Y.; Koyama, T.
Substrate specificities of farnesyl diphosphate synthases of Bacillus stearothermophilus and porcine liver with allylic substrate homologs having vinyl or ethynyl group
J. Mol. Catal. B
59
163-167
2009
Sus scrofa
-
Nagaki, M.; Nakada, M.; Musashi, T.; Kawakami, J.; Endo, T.; Maki, Y.; Koyama, T.
Substrate specificities of wild and mutated farnesyl diphosphate synthases: Reactivity of allylic substrate homologs having hydrophilic groups at omega-position
J. Mol. Catal. B
59
225-230
2009
Geobacillus stearothermophilus, Sus scrofa
-
Nagaki, M.; Kanno, H.; Musashi, T.; Shimizu, R.; Maki, Y.; Sagami, H.; Koyama, T.
Substrate specificities of farnesyl diphosphate synthases from Bacillus stearothermophilus and porcine liver with cyclic substrate homologs
J. Mol. Catal. B
60
186-190
2009
Geobacillus stearothermophilus, Sus scrofa
-
Gilg, A.B.; Tittiger, C.; Blomquist, G.J.
Unique animal prenyltransferase with monoterpene synthase activity
Naturwissenschaften
96
731-735
2009
Ips pini (Q58GE8), Ips pini
Chang, T.H.; Hsieh, F.L.; Ko, T.P.; Teng, K.H.; Liang, P.H.; Wang, A.H.
Structure of a heterotetrameric geranyl pyrophosphate synthase from mint (Mentha piperita) reveals intersubunit regulation
Plant Cell
22
454-467
2010
Mentha x piperita
Schmidt, A.; Waechtler, B.; Temp, U.; Krekling, T.; Seguin, A.; Gershenzon, J.
A bifunctional geranyl and geranylgeranyl diphosphate synthase is involved in terpene oleoresin formation in Picea abies
Plant Physiol.
152
639-655
2010
Picea abies (D2IT07), Picea abies
Mann, F.M.; Thomas, J.A.; Peters, R.J.
Rv0989c encodes a novel (E)-geranyl diphosphate synthase facilitating decaprenyl diphosphate biosynthesis in Mycobacterium tuberculosis
FEBS Lett.
585
549-554
2011
Mycobacterium tuberculosis, Mycobacterium tuberculosis CDC 1551
Nagegowda, D.
The small subunit of geranyl diphosphate synthase: A tool to improve aroma and flavour by metabolic engineering
J. Biosci.
35
167-169
2010
Antirrhinum majus, Clarkia breweri (Q6QLU5), Mentha x piperita (Q9SBR4)
Schmidt, A.; Nagel, R.; Krekling, T.; Christiansen, E.; Gershenzon, J.; Krokene, P.
Induction of isoprenyl diphosphate synthases, plant hormones and defense signalling genes correlates with traumatic resin duct formation in Norway spruce (Picea abies)
Plant Mol. Biol.
77
577-590
2011
Picea abies
Frick, S.; Nagel, R.; Schmidt, A.; Bodemann, R.R.; Rahfeld, P.; Pauls, G.; Brandt, W.; Gershenzon, J.; Boland, W.; Burse, A.
Metal ions control product specificity of isoprenyl diphosphate synthases in the insect terpenoid pathway
Proc. Natl. Acad. Sci. USA
110
4194-4199
2013
Phaedon cochleariae
Zhou, J.; Wang, X.; Kuang, M.; Wang, L.; Luo, H.; Mo, Y.; Wu, R.
Protonation-triggered carbon-chain elongation in geranyl pyrophosphate synthase (GPPS)
ACS Catal.
5
4466-4478
2015
Mentha x piperita (Q9SBR3 and Q9SBR4)
-
Pockrandt, D.; Li, S.M.
Geranylation of cyclic dipeptides by the dimethylallyl transferase AnaPT resulting in a shift of prenylation position on the indole ring
ChemBioChem
14
2023-2028
2013
Aspergillus fischeri
Heider, S.A.; Peters-Wendisch, P.; Beekwilder, J.; Wendisch, V.F.
IdsA is the major geranylgeranyl pyrophosphate synthase involved in carotenogenesis in Corynebacterium glutamicum
FEBS J.
281
4906-4920
2014
Corynebacterium glutamicum, Corynebacterium glutamicum ATCC 13032
Rivera-Perez, C.; Nyati, P.; Noriega, F.G.
A corpora allata farnesyl diphosphate synthase in mosquitoes displaying a metal ion dependent substrate specificity
Insect Biochem. Mol. Biol.
64
44-50
2015
Aedes aegypti (Q17F78)
Liu, Z.; Zhou, J.; Wu, R.; Xu, J.
Mechanism of assembling isoprenoid building blocks 1. elucidation of the structural motifs for substrate binding in geranyl pyrophosphate synthase
J. Chem. Theory Comput.
10
5057-5067
2014
Mentha x piperita (Q9SBR3 and Q9SBR4)
Rai, A.; Smita, S.S.; Singh, A.K.; Shanker, K.; Nagegowda, D.A.
Heteromeric and homomeric geranyl diphosphate synthases from Catharanthus roseus and their role in monoterpene indole alkaloid biosynthesis
Mol. Plant
6
1531-1549
2013
Catharanthus roseus (B2MV87), Catharanthus roseus
Liebhold, M.; Li, S.M.
Regiospecific benzylation of tryptophan and derivatives catalyzed by a fungal dimethylallyl transferase
Org. Lett.
15
5834-5837
2013
Aspergillus fumigatus
Xi, J.; Rossi, L.; Lin, X.; Xie, D.Y.
Overexpression of a synthetic insect-plant geranyl pyrophosphate synthase gene in Camelina sativa alters plant growth and terpene biosynthesis
Planta
244
215-230
2016
Myzus persicae
Keeling, C.I.; Chiu, C.C.; Aw, T.; Li, M.; Henderson, H.; Tittiger, C.; Weng, H.B.; Blomquist, G.J.; Bohlmann, J.
Frontalin pheromone biosynthesis in the mountain pine beetle, Dendroctonus ponderosae, and the role of isoprenyl diphosphate synthases
Proc. Natl. Acad. Sci. USA
110
18838-18843
2013
Dendroctonus ponderosae (I1VJ84), Dendroctonus ponderosae
Yang, L.; Jiang, L.; Li, W.; Yang, Y.; Zhang, G.; Luo, Y.
A homomeric geranyl diphosphate synthase-encoding gene from Camptotheca acuminata and its combinatorial optimization for production of geraniol in Escherichia coli
J. Ind. Microbiol. Biotechnol.
44
1431-1441
2017
Camptotheca acuminata (A0A2H4ULH9), Camptotheca acuminata
Rubat, S.; Varas, I.; Sepulveda, R.; Almonacid, D.; Gonzalez-Nilo, F.; Agosin, E.
Increasing the intracellular isoprenoid pool in Saccharomyces cerevisiae by structural fine-tuning of a bifunctional farnesyl diphosphate synthase
FEMS Yeast Res.
17
fox032
2017
Saccharomyces cerevisiae
Picard, M.E.; Nisole, A.; Beliveau, C.; Sen, S.; Barbar, A.; Shi, R.; Cusson, M.
Structural characterization of a lepidopteran type-II farnesyl diphosphate synthase from the spruce budworm, Choristoneura fumiferana Implications for inhibitor design
Insect Biochem. Mol. Biol.
92
84-92
2018
Choristoneura fumiferana (Q1XAB1)
Lee, J.S.; Pan, J.J.; Ramamoorthy, G.; Poulter, C.D.
Structure-function studies of Artemisia tridentata farnesyl diphosphate synthase and chrysanthemyl diphosphate synthase by site-directed mutagenesis and morphogenesis
J. Am. Chem. Soc.
139
14556-14567
2017
Artemisia spiciformis, Artemisia spiciformis (Q7XYS8)
Han, S.; Li, X.; Xia, Y.; Yu, Z.; Cai, N.; Malwal, S.R.; Han, X.; Oldfield, E.; Zhang, Y.
Farnesyl pyrophosphate synthase as a target for drug development discovery of natural-product-derived inhibitors and their activity in pancreatic cancer cells
J. Med. Chem.
62
10867-10896
2019
Homo sapiens (P14324)
Barja, M.V.; Rodriguez-Concepcion, M.
A Simple In vitro assay to measure the activity of geranylgeranyl diphosphate synthase and other short-chain prenyltransferases
Methods Mol. Biol.
2083
27-38
2020
Arabidopsis thaliana (P34802)
Park, J.; Zielinski, M.; Magder, A.; Tsantrizos, Y.S.; Berghuis, A.M.
Human farnesyl pyrophosphate synthase is allosterically inhibited by its own product
Nat. Commun.
8
14132
2017
Homo sapiens (P14324)
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