2.5.1.10: (2E,6E)-farnesyl diphosphate synthase

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For detailed information about (2E,6E)-farnesyl diphosphate synthase, go to the full flat file.

Word Map on EC 2.5.1.10

2.5.1.10

bisphosphonates

mevalonate

isoprenoids

geranylgeranylation

nitrogen-containing

prenylation

sterol

zoledronate

cholesterol

resorption

dimethylallyl

squalene

osteoclast

osteoporosis

alendronate

risedronate

prenyltransferases

sesquiterpene

terpenoids

dmapp

allyl

hmg-coa

3-hydroxy-3-methylglutaryl

monoterpene

isoprenylation

pamidronate

ibandronate

farnesol

isoprene

dolichols

srebps

osteoclast-mediated

annua

aspartate-rich

clodronate

cis-prenyltransferase

etidronate

homoallylic

anti-resorptive

geranylgeraniol

aminobisphosphonates

paget

phosphomevalonate

polyprenyl

drug development

branch-point

minodronate

nonsterol

amorpha-4,11-diene

medicine

phosphoantigens

molecular biology

Reaction

Synonyms

At4g36810, bifunctional farnesyl/geranylgeranyl diphosphate synthase, E-farnesyl diphosphate synthase, E-FPP synthase, ERG20, farnesyl diphosphate synthase, farnesyl diphosphate synthase 1, farnesyl diphosphate synthase 2, farnesyl pyrophosphate synthase, farnesyl pyrophosphate synthetase, farnesyl-diphosphate synthase, farnesylpyrophosphate synthetase, FDPSase, FDS, FPP synthase, FPP-synthase, FPPase, FPPS, FPPS/GGPPS, FPPS1, FPPS2, FPPS3, FPS, Fps1, FPS2, geranyl transferase I, geranyltranstransferase, GGPPS11, hFPPS, HpGGPPS, IspA, LS1, MpFPPS1, MpFPPS2, omega,E,E-farnesyl diphosphate synthase, omega,E,E-FPP, PA4043, PcIDS1, prenyltransferase, type I farnesyl diphosphate synthase

ECTree

2 Transferases

2.5 Transferring alkyl or aryl groups, other than methyl groups

2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

2.5.1.10 (2E,6E)-farnesyl diphosphate synthase

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Results	in table
10	Activating Compound
7438	AA Sequence
5	Application
1	CAS Registry Number
28	Cloned(Commentary)
16	Crystallization (Commentary)
366	Disease/ Diagnostics
6	Expression
54	General Information
1	General Stability
142	IC50 Value
275	Inhibitors
21	Ki Value [mM]
47	KM Value [mM]
6	Localization
31	Metals/Ions
32	Molecular Weight [Da]
60	Natural Substrates/ Products (Substrates)
295	Organism
1	Oxidation Stability
10	Pathway
255	PDB ID
9	pH Optimum
3	pH Range
1	pH Stability
9	pI Value
66	Protein Variants
27	Purification (Commentary)
2	Reaction
1	Reaction Type
103	Reference
32	Source Tissue
14	Specific Activity [micromol/min/mg]
4	Storage Stability
145	Substrates and Products (Substrate)
32	Subunits
147	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
1	Temperature Range [°C]
2	Temperature Stability [°C]
6	Turnover Number [1/s]

Purification

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Purification on EC 2.5.1.10 - (2E,6E)-farnesyl diphosphate synthase

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9 entries

ammonium sulfate, affinity chromatography

2 entries

ammonium sulfate, Sephadex G 200, hydroxylapatite

Pumpkin

638684

ammonium sulfate, Sephadex G-100, hydroxylapatite, DEAE-Sephadex A-50

Bacillus subtilis

638683

anti-FLAG M2 affinity resin chromatography and nickel affinity column chromatography

Toxoplasma gondii

Q197X6

721671

DEAE-Sepharose, Mono Q, phenyl-Sepharose

Abies grandis

638706

fusion protein

Mycobacterium tuberculosis

659667

hexahistidine-tagged octaprenyl diphosphate synthase

Escherichia coli

P22939

758934

HisTrap Ni2+ chelate affinity chromatography

Trypanosoma cruzi

722923

HisTrap Ni2+-chelate column chromatography

Leishmania major

737349

Ni-NTA column chromatography

3 entries

Ni-NTA resin column chromatography

Matricaria chamomilla var. recutita

A7L691

738331

Ni-NTA resin column chromatography and Superdex 200 gel filtration

Pseudomonas aeruginosa

partial purification

recombinant protein

TALON resin Co2+ metal affinity column chromatography

Rhopalosiphum padi

G0YZR3, G0YZR4

723709